NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	107-11-9
Chemical Name	3-Amino-1-propene; Allylamine
Substance ID	m-nite-107-11-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of -29 deg C (closed cup) and a boiling point of 52-53 deg C (Hommel (1991)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but the classification is not possible due to no data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 370 deg C (Hommel (1991)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to low-temperature-boiling liquids are not available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	Not classified	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 3. [Evidence Data] (1) LD50 for rats: 102 mg/kg (PATTY (6th, 2012), HSDB (Access on June 2019)) (2) LD50 for rats: 106 mg/kg (HSDB (Access on June 2019))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 1	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	[Rationale for the Classification] Base on (1), it was classified in Category 1. [Evidence Data] (1) LD50 for rabbits: 35 mg/kg (PATTY (6th, 2012), HSDB (Access on June 2019))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 2. Besides, LC50 values were lower than 90% of the saturated vapor concentration (318,446 ppm), therefore, the reference value in units of ppm was applied as vapour with little mist. [Evidence Data] (1) LC50 for rats (4 hours): 286 ppm (PATTY (6th, 2012), HSDB (Access on June 2019)) [Reference Data, etc.] (2) LC50 for rats (8 hours): 177 ppm (converted 4-hour equivalent value: 250.32 ppm) (PATTY (6th, 2012))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1. Besides, since new data were obtained, the category was changed. [Evidence Data] (1) In an in vitro skin corrosion test using an artificial skin model (EpiDerm) in accordance with OECD TG 431, after 3 or 60 minutes of exposure, the viability was 12.8% or 8.4%, respectively (REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (2) This substance is a severe eye and skin irritant (PATTY (6th, 2012)). (3) This substance is a severe skin and eye irritant in humans (HSDB (Access on June 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on data of (1)-(4) and the fact that it was judged to be skin corrosive (Category 1), it was classified in Category 1. Besides, since detailed data was obtained, the category was changed. [Evidence Data] (1) This substance is a severe eye and skin irritant (PATTY (6th, 2012)). (2) This substance is a severe skin and eye irritant in humans (HSDB (Access on June 2019)). (3) There is a report that in an eye irritation test with rabbits, equivalent or similar to OECD TG 405 (applied with 0.05 mL), it was highly irritating (REACH registration dossier (Access on July 2019)). (4) In an in vitro skin corrosion test using an artificial skin model (EpiDerm) in accordance with OECD TG 431, it was judged to be a corrosive substance (Category 1) (REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (5) In the case of accidental exposure to the vapors of this substance, transient irritation to the mucous membranes of the nose, eyes and mouth occurred, resulting in lacrimation, coryza and sneezing (PATTY (6th, 2012)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] There are no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, there is a negative result in a bacterial reverse mutation test (NTP DB (Access on June 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Although no reproductive toxicity was observed in (1), this test is a screening test and there are no data from developmental toxicity tests, therefore, classification is not possible due to lack of data. [Evidence Data] (1) In a reproduction/developmental toxicity screening test with rats exposed by inhalation (OECD TG 421), no reproductive toxicity was observed at concentrations where parental toxicity (underactivity, piloerection, hunched posture and decreased body weight gain) was observed (REACH registration dossier (Access on July 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (cardiovascular system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	[Rationale for the Classification] Based on human exposure cases in (1)-(3) and the results in rats in (4), it was classified in Category 1 (cardiovascular system), Category 3 (respiratory tract irritation). Although the lung was included as a target organ in the previous classification, the original source was listed in List 3 and there is no other supporting information, therefore, the classification result was changed. [Evidence Data] (1) Mucous membrane irritation and chest discomfort occurred in some persons after inhalation of this substance at 2.5 ppm (PATTY (6th, 2012), HSDB (Access on June 2019)). (2) Inhalation of the vapors of this substance at 14 ppm caused intolerable irritation of the eyes and respiratory tract in humans (HSDB (Access on June 2019)). (3) Researchers (several) exposed to the vapor (concentration unknown) of this substance by an accident experienced transient irritation of the mucous membranes of the nose, eyes, and mouth, with lacrimation, coryza, and sneezing (PATTY (6th, 2012), HSDB (Access on June 2019)). (4) In a single inhalation exposure test with rats, perivascular edema and cellular infiltration were observed in the heart after 4-hour exposure at 100 ppm (corresponding to Category 1), and an obvious myocardial lesion was confirmed in one animal (NRC Committee on AEGL (2007)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (cardiovascular system)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1), effects on the cardiac muscle and blood vessels were observed after oral administration to rats, therefore, it was classified in Category 1 (cardiovascular system). Since information sources were reviewed, the classification result was changed from the previous classification. [Evidence Data] (1) In a study in which male rats were administered 0.005 to 0.1% of this substance in drinking water for 21-104 days, it caused dose-dependent myocardial and vascular lesions, and after three weeks of treatment (converted guidance value: 1.5-29 mg/kg/day, within the range of Category 1-Category 2), severe myocardial fibrosis was developed (PATTY (6th, 2012), HSDB (Access on June 2019)). [Reference Data, etc.] (2) In a study in which localized arteritis was observed following intradermal injection of this substance, cardiotoxicity was reported (PATTY (6th, 2012)). (3) Allylamines are known to be cardiotoxins. They can cause acute myocardial necrosis that is cumulative with repeated administrations, as well as vascular proliferative lesions after several weeks of treatment (PATTY (6th, 2012)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Besides, although there is information of (1), no other information is available to provide the evidence of the classification, therefore, it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) Although there is a possibility of pneumonia due to aspiration in humans (SITTIG (6th, 2012)), no other information is available to provide the evidence of the classification, therefore, classification is not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 48-hour LC50 = 35.9 mg/L [geometric average, N = 10] for crustacea (Daphnia magna) (EPA AQUIRE: 2018, Canton, J. H. et al. (1978)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Chronic toxicity data were not obtained. Although appropriate data on rapid degradability were not obtained, it was classified as "Not classified" due to no bioaccumulation (LogKow: 0.03 (PHYSPROP Database: 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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