Item | Information |
---|---|
CAS RN | 107-22-2 |
Chemical Name | Glyoxal |
Substance ID | m-nite-107-22-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. Besides, it is described in ICSC (2003) that an autoignition temperature is 285 deg C or higher for a 40% aqueous solution. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to liquid (a boiling point < 55 deg C ) substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
It was classified in Category 3 based on an LD50 value of 200 mg/kg for rats (Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on LD50 = 12,700 mg/kg in a dermal administration test with rabbits (CICAD 57 (2004)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
There are reports of LC50 (4 hours) = 2,440 mg/m3 (2.44 mg/L) in an inhalation exposure test with rats on a 40% aqueous solution (aerosol) (SIDS (2003), CICAD 57 (2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Based on the description that the LC50 value is a calculated one (CICAD 57 (2004)), a reference value in the unit of mg/L was applied as a mist, and it was classified in Category 4. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
As the results of skin irritation tests with rabbits, it is described that severe irritation (SIDS (2003)), slight irritation (SIDS (2003)), or erythema was observed (CICAD 57 (2004)), or there was no irritation (SIDS (2003)). As effects in humans, it is described that it is considered to irritate the eye, skin, and mucous membrane of humans at present (Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004)). Furthermore, this substance is classified in "Xi; R36/38" in EU DSD classification and "Skin Irrit. 2 H315" in EU CLP classification. Based on the above information, it was thought to cause reversible and severe irritation, and it was classified in Category 2. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
It is described that slight irritation was observed in an eye irritation test with rabbits (according to OECD TG 405) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for other tests with rabbits, it is described that reddening and chemosis were found, and these subsided after eight days, or that severe reddening and slight edema in the conjunctiva and inflammation and a hazy clouding of the iris were seen, and the symptoms healed within 1 or 2 weeks (SIDS (2003)). Furthermore, this substance is classified in "Xi; R36/38" in EU DSD classification and "Eye Irrit. 2 H319" in EU CLP classification. Based on the above information, it was thought to cause reversible and severe irritation, and it was classified in Category 2A. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It is described that it was positive in a Buehler test and a maximization test, both using guinea pigs (SIDS (2003)). As epidemiological cases in humans, it is described that in a maximization test, necrosis, erythema, and edema in the skin were observed (SIDS (2003)), and positive skin reactions were found in all subjects after induction with a 10% solution and a challenge with a 2% solution, and glyoxal was shown to be a strong skin sensitizer (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Therefore, it was considered to cause skin sensitization. Furthermore, this substance is classified in "R43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification. It was classified in Category 1 based on the above information. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As for in vivo, it was reported to be negative in a micronucleus test with mouse bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2003), CICAD 57 (2004)). And it was negative in an unscheduled DNA synthesis (UDS) test with rat liver (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2003)), but positive results were observed in a UDS test with pyloric mucosa of rat stomach and a DNA single-strand-break test with rats liver (SIDS (2003), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004), CICAD 57 (2004), ACGIH (7th, 2001)). Both of the positive results were assessed to be local DNA damage (SIDS (2003)). On the other hand, as for in vitro, it was positive in a bacterial reverse mutation test, and a gene mutation test and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2003), CICAD 57 (2004), Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004), ACGIH (7th, 2001)). The category was changed according to the revised GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it is classified in A4 in ACGIH (7th, 2001). The category was changed according to the revised GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | There is the information that there was no developmental toxicity at the dose where maternal toxicity occurred (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2003)), but there is no information on the effects on sexual function and fertility. Therefore, it was classified as "Classification not possible" due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 2 (lung, kidney, adrenal gland, respiratory organs, central nervous system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
The digestive system, respiratory system, kidney, adrenal gland, and central nervous system are considered to be the target organs because the autopsy showed changes in the gastrointestinal tract (irritation of the gastrointestinal tract), lung, kidney, and adrenal gland in acute toxicity tests with rats, mice, and other species, and because dyspnea, irregular breathing, central nervous system depression, and hyperemia in the lung were observed in an inhalation (aerosol) exposure test with rats (SIDS (2003), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Among the organs mentioned above, the digestive system was not included in the target organs because this substance is irritating. Besides, effects in experimental animals were found within the guidance value range corresponding to Category 2 (the oral route (640-1,400 mg/kg (rats)), the inhalation route (1.3 mg/L or above)). From the above, it was classified in Category 2 (lung, kidney, adrenal gland, respiratory system, central nervous system). Besides, the heart and liver were also included in the target organs in the previous classification, but these were removed because they were not described as the target organs in the information sources used this time. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
It was classified in Category 1 (respiratory system) because squamous metaplasia of the epiglottal epithelium accompanied by submucosal lymph cell infiltration was observed at the concentration (converted guidance value: 0.0003 mg/L) within the guidance value range for Category 1 in a 29-day inhalation exposure test with rats (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Besides, in a 28-day oral administration test with rats, decreased weight gain and decreased food consumption were found at the dose (converted guidance value: 40 mg/kg/day) within the guidance value range for Category 2, but there were no pathological changes to enable specifying the target organs (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
From 96-hour LC50 = 86 mg/L for fish (Pimephales promelas) (Initial Risk Assessment (NITE, CERI, NEDO, 2008); SIDS, 2003), it was classified in Category 3. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified in Category 3 in acute toxicity. However, it is rapidly degradable (a 28-day degradation rate by BOD = 65% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1996)), and low bioconcentration is estimated (LogPow = -1.66 (HSDB, 2013)). Therefore, it was classified as "Not classified." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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