NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	107-41-5
Chemical Name	2-Methyl-2,4-pentanediol (Hexyleneglycol)
Substance ID	m-nite-107-41-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	It was classified in Category 4 from a flash point of 90 deg C (closed cup) (GESTIS (Accessed Jan. 2019)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Flash point: 306degC (ICSC (J), 2003)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Rat LD50 value: 4470mg/kg (SIDS, 2001, DFGOT vol.16, 2001), 4700mg/kg (SIDS, 2001, DFGOT vol.16, 2001), 3700mg/kg (SIDS, 2001, DFGOT vol.16, 2001, PATTY 4th, 1994), 4760mg/kg (SIDS, 2001), 3680mg/kg (SIDS, 2001), 4790mg/kg (ACGIH 7th, 2001, PATTY 4th, 1994) and 4200mg/kg (PATTY 4th, 1994). Inspite of the data above, LD50 value was found to be :>2000mg/kg in GLP study following OECD 402 using rats in SIDS (2001), no death would be observed less than 2000mg/kg value, and it was considered out of category.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was set as the outside of Category based on rabbit and rat LD50 value. Rabbit LD50 values: >5000mg/kg (SIDS, 2001, DFGOT vol.16, 2001), >1840mg/kg (SIDS, 2001), 12300mg/kg (SIDS, 2001, ACGIH 7th, 2001, DFGOT vol.16, 2001, PATTY 4th, 1994), >8680mg/kg (SIDS, 2001), 7900mg/kg (SIDS, 2001, DFGOT vol.16, 2001, PATTY 4th, 1994), and >10000mg/kg (DFGOT vol.16, 2001). Rat LD50 value: >2000mg/kg (OECD 402 conformity GLP test, SIDS, 2001), and it judged that death was not observed at 2000mg/kg or less in rats.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Not classified	- -	-	-	From description that irritation was not acknowledged by exposure for 4 hours in the skin irritation test using the rabbit on SIDS (2001) and DFGOT (vol.16, 2001), it was carried out the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Change of the eye applicable to the standard of irritation was not acknowledged in the eye irritation tests using the rabbits in SIDS (2001) (OECD Guidelines 405 compatible good laboratory practice tests). However, based on the descriptions that severe irritation was acknowledged in the tests applied to the eyes of the rabbits (SIDS (2001), ACGIH (7th, 2001), DFGOT (vol.16, 2001), PATTY (4th, 1994)), and on the description that in the Draize test using the rabbits, change of the eyes did not completely recover within seven days (SIDS (2001)). So we classified it as Category 2A.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	Based on the description that in Buehler test using the guinea pigs of SIDS (2001) it gave no positive reaction,we classified it to be Out Of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	It was considered as out of Category based on the description that clear reproductive toxicity was not observed even at the dose in which general toxicity is observed in dam animals in the teratogenicity test by the oral administration using rat (SIDS (2001)).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Because of descriptions in SIDS (2001), ACGIH (7th, 2001), DFGOT (vol.16, 2001), and PATTY (4th, 1994) referring to that respiratory irritant was confirmed in humans exposure cases, and of descriptions in SIDS (2001) and ACGIH (7th, 2001) referring to confirmation of symptoms indicating anesthetic actions in oral administration studies using rats or mice. So it was judged as Category 3 (anesthetic actions, respiratory irritant).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	We considered it as Out Of Category based on the description that the significant toxic action was not observed with the dose which exceeds the guidance value range of Category 2 in the oral administration examination using the rat or in the dermal administration test using the rabbit (SIDS (2001), DFGOT (16 vol. 2001), and PATTY (4th, 1994)). Moreover, we found the descriptions that a toxic phenomena was not observed in the oral study for humans (SIDS (2001) and DFGOT (vol.16, 2001)).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	It carried out the outside of Category from 96-hour LC50>100 mg/L (MOE eco-toxicity tests of chemicals, 1997) of fishes (Oryzias latipes).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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