Item | Information |
---|---|
CAS RN | 107-87-9 |
Chemical Name | Methyl propyl ketone |
Substance ID | m-nite-107-87-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of 7 deg C (closed cup), and a boiling point of 102 deg C (ICSC (1998)), it was classified in Category 2. Besides, it is classified in Class 3, PG II (UN 1249) in UNRTDG. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from autoignition temperatures of 505 deg C (ICSC (1998)), and 452 deg C (HSDB (Access on August 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | There are two reports of LD50 values for rats of 1,600-3,200 mg/kg and 3,730 mg/kg (PATTY (6th, 2012)). One corresponds to Category 4 or "Not Classified" and the other corresponds to "Not Classified." The substance was classified as "Not Classified" (Category 5 in UN GHS classification) to which the larger number of values corresponds. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the report of the LD50 value of 6,472 mg/kg for rats (PATTY (6th, 2012)), this substance was classified as "Not classified." | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is a report of an LC50 value (4 hours) for rats of > 2,000 mg/m3 (PATTY (6th, 2012), ACGIH (7th, 2001)). However, it was not possible to identify the category from this value alone. Besides, since the LC50 value was lower than 90% of the saturated vapor pressure concentration (21,053 ppm), a reference value in the unit of ppm was applied as vapor without mist. Classification was conducted by using the lowest LC50 value in the rationale of the previous classification, therefore, the category was revised. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Because LC50 values cannot be presumed from the data of the evidence of previous classification, the category was revised. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Based on the description that it is considered that it shows mild irritation as a result of application of the undiluted solution of this substance to rabbits (ACGIH (7th, 2007)) and the description that mild irritation was observed as a result of application of this substance to guinea pigs (PATTY (6th, 2012)), the substance was classified as "Not Classified" (Category 3 in UN GHS classification). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
There is a report that irritation was observed due to exposure of guinea pigs to the vapor of this substance (ACGIH (7th, 2007)) and a description that this substance showed mild to moderate irritation in rabbit eyes (PATTY (6th, 2012)). There is also a report that irritation was observed in human eyes due to exposure to the vapor of this substance (ACGIH (7th, 2007), PATTY (6th, 2012)). Based on the above, it was classified as Category 2. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. No in vivo data were available, and as for in vitro, a bacterial reverse mutation test was negative (NTP DB (Access on October 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Since there are no classification results by other organizations, classification is not possible due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | It is described that in a reproduction/developmental toxicity screening test by inhalation with rats, except that reduced activity was observed at the highest dose of 5.0 mg/L in parental animals, adverse effects were observed in none of pathological abnormalities in female and male genetic organs and effects on fertility in the parent animals, and the survival rate and the changes in body weight up to postnatal day 4 in pups (PATTY (6th, 2012)). However, it was not possible to classify as "Not classified" only by this result because this test is a screening test. Therefore, this substance was classified as "Classification not possible" due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance is irritating to the respiratory tract in humans (ACGIH (7th, 2007), PATTY (6th, 2012)). In experimental animals, there are reports of narcotic effects in inhalation exposure of rats and guinea pigs (ACGIH (7th, 2007), PATTY (6th, 2012)). Based on the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | There is no information on repeated exposure to this substance in humans. In experimental animals, there is a description in a test in which rats were given this substance in drinking water for 13 months, at a dose exceeding Category 2 (10,000 ppm: 250-452 mg/kg/day), a transient suppression of body weight gain was observed, but there was no abnormality in clinical symptoms, organ weights, and pathological findings (PATTY (6th, 2012)) and there is a description in a neurotoxicity screening test in which rats were exposed by inhalation at 305 ppm for 17.5 weeks, central and peripheral nerve specimens were examined histopathologically but no abnormality was observed at the test concentration (converted guidance value: 1.84 mg/L/6 hr/day (exceeding the guidance value range of Category 2)). Based on the above, no significant toxicological effects were observed in the oral and inhalation routes, but the inhalation toxicity test was a screening test, and sufficient test items were not set, and neither test data were quoted in ACGIH (7th, 2007), therefore, it was classified as "Classification not possible" due to lack of data for this hazard class. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | There are no cases of aspiration hazard in humans. However, this substance belongs to ketones composed of carbon atoms not less than 3 and not more than 13, and based on numerical data (viscosity: 0.473 mPa*s (25 deg C), density (specific gravity): 0.809 (20 deg C)) listed in HSDB (Access on August 2015), the calculated kinematic viscosity is 0.585 mm2/sec (25/20 deg C). Although it corresponds to Category 2 in the UN GHS classification, this substance was classified as "Classification not possible" according to the current guidance revised after the previous classification. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | From 96-hour LC50 = 1210 mg/L for fish (Pimephales promelas) (HSDB, 2008), it was classified as "Not classified." | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. Due to being not water-insoluble (water solubility = 43000mg/L, PHYSPROP Database, 2009), and "Not classified" in acute toxicity, it was classified as "Not classified." | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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