NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	108-70-3
Chemical Name	1,3,5-Trichlorobenzene
Substance ID	m-nite-108-70-3_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified	- -	-	-	Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2321 (HSDB (2008)), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Since it was classified into Class 6.1 an PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2321 (HSDB (2008)), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Although it is an organic compound including chlorine, not oxygen and fluorine, chlorine has bound only to carbon.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	As LD50 value of the oral administration test employing a rat, there is a description of 1,800 mg/kg, 2,100 mg/kg, 2,490 mg/kg, and 2,800 mg/kg in DFGOT vol.3 (1992), and a description of 800 mg/kg 4th volume (2005) of the MOE risk assessment. Since there existed two or more data which corresponded to Category 4 and "Not classified", high-risk category was adopted and considered it as Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	It is written that there was no mortality in the test in which 1-hour inhalation exposure of the saturated steam was carried out to rats (DFGOT vol.3 (1992)). Although a vapor standard is applied from saturated vapor pressure level (25degC) with 2.3 mg/L, 4-hour equivalent LC50 value is presumed to be >1.15 mg/L, classification is not possible since classification cannot be specified, .	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	It is written that lethal concentration of the inhalation exposure test employing rats (1 hour) is >9,300 mg/m3 (the 4th volume (2005) of MOE Risk Assessment). When applying the dust standard from saturated vapor pressure level with 2.3 mg/L at 25degC, 4-hour equivalent LC50 value is presumed to be >2.3 mg/L, however, classification is not possible since classification cannot be specified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	There is a description of a 24 hour batch test with rabbits in DFGOT vol 3 (1992), saying, " Erythema and edema were observed in 6/6 and erythema was observed in 3/6 animals in 72 hours. This substance therefore is mild irritant." and there is a description of a similar batch test using rabbits, saying, "Noteworthy dermal changes that are the special feature of irritation were observed." Although it seemed to correspond to UN GHS Skin irritation Category 3 based on the above-mentioned, it was classified into "Not classified", because Category 3 is not domestically adopted.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In DFGOT vol.3 (1992), there is a description of "In the test where 100 mg of this substance was instilled into the eyes of a rabbit, mild and temporary redness, conjunctiva dropsy, and eye discharge arose and the recovery took seven days in the rabbit which was not rinsed." and a description of "The irritation to mucosa ranged from mild to moderate " in the test where it was medicated to the eyes of a rabbit. As mentioned above, it was classified into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Although it has been described that "sensitizing properties were not observed" in the test employing guinea pig (DFGOT vol.3 (1992)), classification is not possible because of no other data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although there is a description of "slightly positive" by a body cell in vivo mutagenicity test (micronucleus tests which employed mouse erythrocyte) (DFGOT vol.3 (1992)), EU-RAR which is about isomer 1,2,4-trichlorobenzene (2003) described on this test that "a question lingers in the validity of positive finding since the test protocol is not so suitable"On the other hand, there is a description that the in vitro mutagenicity test (chromosome aberration test employing a chinese hamster cells --) and the Ames test employing Salmonella typhimurium and bacillus coli was "negative" (CaPSAR (1993), NTP DB (Access on December 2008), DFGOT vol.3 (1992)). As mentioned above, since there is not enough data for classifying, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	There is a description as follows, "A significant increase in the liver weight, changes in liver tissues, and decrease in hemoglobin cocentrations and hematocrit values with mother animals were observed in the forced oral administration study with rats of 6-15 day pregnancy. Although disorders were observed in the crystsl lens of fetuses' eyes, changes in the number of fetuses and fetuses' body weight and deformation of bone structure and internal organs were not observed" (MOE Risk Assessment Vol.4 (2005), HSDB (2004)). There is a description as follows, however, about this study, "Since the effect on eyes was not dose dependent, there seems to be no relation between this substance and exposure."(EU-RAR (2003)) In addition, there is a description as follows in the forced oral administration study applied to rats for 6-15 days during pregnancy, "Lesions in the liver and thyroid gland and decrease in hematocrit values and hemoglobin concentrations were observed. Although slight osteogenic changes were observed in fetuses, no serious deformation was observed" (Patty (5th, 2001), DFGOT vol. 3 (1992)). There is no other data and, since the effects on reproductive functions are not known, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	It is indicated that "nerve tremor, entasia, nasal mucus mixed with blood, dacryorrhea, and noisy breathing occur as with nonspecific symptom (piloerection, inactivity, disequilibrium, ataxia, etc.) at a high dose" in the paragraph of the acute toxicity of DFGOT vol.3 (1992) for animals. For humans, it is described as "An airway is irritated and cough and pharynx pain occur as acute symptoms." as effect on humans in MOE Risk Assessment, Volume 4 (2005)). For the animals' data, since the dose was unknown and the classification was not able to be identified, it was not adopted, thus, it was classified into Category 3 (Respiratory tract irritation).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, kidney, thyroid, nasal cavity)	Warning	H373	P260 P314 P501	It has been described that, in the 13-weeks mixed feed administration test employing rats, " the weight increase of liver and kidney in female, increase of hepatic cell capacity and anisokaryosis increase in male and female, follicle reduction in thyroid gland, increase of the height of a follicular cell, colloid density reduction, and mild to moderate denaturation of nephric tubule in kidney" (MOE Risk Assessment, Volume 4 (2005)), CaPSAR (1993), Patty (5th, 2001), DFGOT vol.3 (1992)). There are descriptions of "The increase in the relative weight of liver was seen" in 4 weeks inhalation exposure test employing rats. (CaPSAR (s) (1993)) and of "The squamous metaplasia and hyperplasia of the respiratory nasal airway epithelium were observed" in 13 weeks inhalation exposure test employing rats. (CaPSAR (s) (1993), MOE Risk Assessment, Volume 4 (2005)), DFGOT vol.3 (1992). Since all these symptoms were seen within the range of the guidance value of Category 2, it was classified into Category 2 (liver, kidney, thyroid gland, nasal cavity). In addition, for humans, although there are descriptions of "The woman who had immersed the work clothes in Chlorobenzenes and washed them for a long period of time had experienced the aplastic anemias."(MOE Risk Assessment, Volume 4 (2005)), Patty (5th, 2001) and of "Some worker of 28 workers who was exposed to Trichlorobenzenes complained headache, giddiness, deep sleep, and indigestion" (MOE Risk Assessment, Volume 4 (2005))), the isomer has not been identified and it is unknown whether it is the influence due to this substance, it is not adopted.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 48-hour EC50 = 2.87 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1997), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2009)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1974)) and 21-day NOEC = 0.319 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1997), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2009)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained (fish), then it is classified in Category 2 due to being not rapidly degradable and 96-hour LC50 = 3.2 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1997), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2009)). From the above results, it was classified in Category 2.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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