NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	108-93-0
Chemical Name	Cyclohexanol
Substance ID	m-nite-108-93-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	There is the information that it is combustible (ICSC (J) (1998)), but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 300 deg C (ICSC (J) (1998)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not chlorine or fluorine) which are chemically bonded only to carbon or hydrogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	It is a substance with a melting point of <= 55 deg C, but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a report of an LD50 value of 2,060 mg/kg for rats (ACGIH (7th, 2001)), it was classified as "Not classified" (Category 5 in UN GHS classification). According to the GHS classification guidance for the Japanese government, the category was changed from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Since the data of IUCLID (2000) used in the previous classification could not be obtained and could not be confirmed, it was not used. Therefore, the classification result was changed from the previous classification. Besides, there is a report of the minimum lethal dose value of 2,200-2,600 mg/kg for rabbits (PATTY (6th, 2012)), which exceeds the guidance value range for Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). Besides, since the melting point is 25.93 deg C (HSDB (Access on June 2017)), it is considered to be a liquid at higher temperatures than that.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Solid (GHS definition). However, since the melting point is 25.93 deg C (HSDB (Access on June 2017)), it is considered to be a liquid at higher temperatures than this. There is a report of > 3.6 mg/L (> 882 ppm) as an LD50 value in a 4-hour inhalation exposure test with rats (HSDB (Access on June 2017)). However, because it is not possible to specify a category by this value alone, it was classified as "Classification not possible." Besides, since the exposure concentration is lower than 90% of the saturated vapor pressure concentration (1,287 ppm), a reference value in units of ppm was applied as vapor with little mist.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on a description that it is slightly irritating to human skin (ACGIH (7th, 2001), PATTY (6th, 2012)), and a description that this substance is irritating to the skin in short term exposure (HSDB (Access on June 2017)), it was considered to be an irritant, therefore, it was classified in Category 2. Besides, this substance is classified as "Skin Irrit. 2, H315" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)). The category was changed by re-evaluating the contents of the information source.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on a report that in a test in which this substance was applied to the eyes of rabbits (OECD TG 405 compliant), moderately severe irritation and reversible corneal injuries were observed (ACGIH (7th, 2001)), and a report that in another test with rabbits, the scores of corneal opacity in 4 animals after 4, 24, 48, 72 hours were all 3, and one animal did not recover from injury after 21 days (ECETOC TR48 (2) (1998)), it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, though there is a report that no sensitization was observed in a human patch test (containing 4% of this substance in petrolatum) (PATTY (6th, 2012)), it was not adopted because the details of the test were unknown.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a mouse bone marrow micronucleus test was negative (PATTY (6th, 2012)). As for in vitro, bacterial reverse mutation tests were negative (ACGIH (7th, 2001), PATTY (6th, 2012), NTP DB (Access on July 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is a description that after two strains of mice were dosed by feeding (0.1-1.0%) through the period of gestation and lactation over several generations, in both of the strains, a significant increase in mortality (14.1-53.5%) and slightly inhibited growth during 21 days after birth were observed at a high dose (1.0%) in the pups (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010), PATTY (6th, 2012)). Since effects on the next generation were observed in the situation where the general toxicity effects on parental animals were unknown, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	As for humans, there is a report that irritation of the nose and throat was observed by inhalation exposure to 100 ppm of this substance for 3-5 minutes in a volunteer study (OEL Documentations (Japan Society For Occupational Health (JSOH), 1970), PATTY (6th, 2012)). As for experimental animals, there is a report that in a single dermal exposure test with rabbits, although the doses were not described, the animals showed tremors, narcosis, and hypothermia and died in an application to extensive skin areas at high concentrations (PATTY (6th, 2012)). Therefore, it was classified in Category 3 (respiratory tract irritation, narcotic effects).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (autonomic nervous system), Category 2 (heart, liver, kidney, reproductive organs (male))	Danger Warning	H372 H373	P260 P264 P270 P314 P501	As for humans, there is a report that nonspecific disturbances in the autonomic nervous system were observed in 114 of 453 men and women who had been exposed at concentrations below the permitted level for 2 years, and similar symptoms were observed only in 8 people in the control group (100 people) (ACGIH (7th, 2001)). As for experimental animals, there is a report that in a 10-week inhalation toxicity test with rabbits, within the guidance value range for Category 2, slight degenerations were observed in the liver and kidney at 145 ppm (converted guidance value: 0.33 mg/L), and degenerations in the cardiac muscle, liver and kidney were observed at 272 ppm (converted guidance value: 0.62 mg/L) (PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)). In addition, there is a report that in a 40-day repeated oral dose toxicity test with male rabbits, decreases in the testes and testes weight, inhibition of spermatogenesis, decreases in the diameter of the seminiferous tubules and the volume of the Leydig cell nucleus, sperm deficiency in the lumen of the epididymis and vas deferens, etc. were observed at 25 mg/kg/day (converted guidance value: 11.1 mg/kg/day) within the guidance value range for Category 2 (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)). This was a test with one dose and effects at doses lower than this were unknown, however, the effects were observed in the testes within the guidance value range for Category 2. From the above, it was classified in Category 1 (autonomic nervous system) and Category 2 (heart, liver, kidney, genetic organs (men)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 48-hour EC50 = 17 mg/L for crustacea (Daphnia magna) (NLM HSDB: 2011), it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Chronic toxicity data were not obtained. Due to being rapidly degradable (readily biodegradable, average degradation rate by BOD: 96% (J-CHECK, 1988)), no bioaccumulation (LogKow: 1.23 (SRC PhysProp Database: 2017)), and acute toxicity Category 3, it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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