Latest GHS Classification Results by the Japanese Government (edited by NITE)

Japanese



GENERAL INFORMATION
 
Item Information
CAS RN 109-02-4
Chemical Name 4-Methylmorpholine
Substance ID m-nite-109-02-4_v1
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) To Guidance List
UN GHS document (External link) To UN GHS document
FAQ(GHS classification results by the Japanese Government) To FAQ
List of Information Sources (Excel file) List of Information Sources
List of Definitions/Abbreviations Definitions/Abbreviations
Sample Label by MHLW (External link) MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) To OECD/eChemPortal (External link)

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecules. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
2 Flammable gases Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
5 Gases under pressure Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
Classified into Category 2 since flash point 13 degC (closed-cup) (IMDG (2006)) is <23 degC and initial boiling point 114 degC (Ullmanns (E) (2003)) is >35 degC. The substance is classified into Class 3, Subsidiary risk 8, PG II in UNRTDG (UN2535). FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
7 Flammable solids Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
8 Self-reactive substances and mixtures Not classified (Not applicable)
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
9 Pyrophoric liquids Not classified
-
-
- - Auto-ignition point is 190 degC (Hommel (1996)) exceeding 70 degC. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
10 Pyrophoric solids Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
14 Oxidizing solids Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
16 Corrosive to metals Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
17 Desensitized explosives -
-
-
- - - - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data. As relevant information, a LD50 value is 1960 mg/kg for rats (RTECS (2008)). FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
1 Acute toxicity (Dermal) Category 4


Warning
H312 P302+P352
P362+P364
P280
P312
P321
P501
The LD50 values of 1870 mg/kg (male) and 1820 mg/kg (female) for rats (RTECS (2008), the original literature: Teratogenesis, Carcinogenesis, and Mutagenesis. 19, 369, 1999) correspond to Category 4. As relevant information, a LD50 value is 1350 mg/kg for rabbits (RTECS (2008)). FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
1 Acute toxicity (Inhalation: Gases) Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data. As relevant information, there is information of a LC50 value of 25200 mg/m3/2h (4307 ppm/4h) for mice (RTECS (2008); T). Since the LC50 value was lower than 90% of saturated vapour pressure concentration, the test was considered to be conducted for vapour with almost no included mists. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data. As information in a document in List 3, there is a report of "mild" irritating in an open irritation test where 460 mg of the substance was applied to the skin of rabbits (RTECS (2008)). FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data. As information in a document in List 3, there are reports of "severe" irritating at 920 microg and "mild" irritation at 20 mg for 24-hour in Draize tests by application to the eye of rabbit (RTECS (2008)). FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
4 Respiratory sensitization Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
4 Skin sensitization Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
5 Germ cell mutagenicity Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
6 Carcinogenicity Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
7 Reproductive toxicity Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
10 Aspiration hazard Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
11 Hazardous to the aquatic environment Short term (Acute) Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
11 Hazardous to the aquatic environment Long term (Chronic) Classification not possible
-
-
- - No data available. FY2009 GHS Classification Guidance by the Japanese Government (March, 2009)
12 Hazardous to the ozone layer -
-
-
- - - - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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