Item | Information |
---|---|
CAS RN | 109-06-8 |
Chemical Name | 2-Methylpyridine (2-Picoline) |
Substance ID | m-nite-109-06-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point is 27 deg C (closed cup) (GESTIS (Accessed Sept. 2018)). Besides, it is classified in Class 3, PG III (UN2313) in UNRTDG. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 535 deg C (GESTIS (Accessed Sept. 2018)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
[Rationale for the Classification] Based on data in (1), an LD50 value for rats, it was classified in Category 4. [Evidence Data] (1) LD50 value for rats: 790 mg/kg (PATTY (6th, 2012)) [Reference Data, etc.] (2) The range of LD50 values for rats and mice: 400-1,600 mg/kg (PATTY (6th, 2012)) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
[Rationale for the Classification] Based on data in (1), an LD50 value for rabbits, it was classified in Category 3. [Evidence Data] (1) LD50 value for rabbits: 410 mg/kg (PATTY (6th, 2012)) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
[Rationale for the Classification] As for the 4-hour LC50 value for rats, the data from (1) are reported and they correspond to Category 3 to Category 4. The category with the higher hazard was adopted, and it was classified in Category 3. Since the exposure concentration is lower than 90% of the saturated vapor concentration (14,736 ppm), the reference value in units of ppm was applied as a vapor with little mist. The category was changed from the previous classification by use of the new information sources. [Evidence Data] (1) LC50 value for rats (4 hours): between 2,000-4,000 ppm (death of 0/6 animals at 2,000 ppm and 6/6 animals at 4,000 ppm) (REACH registration dossier (Accessed Sept. 2018)) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. Besides, information for subcategorization was not obtained. [Evidence Data] (1) There is a report that in a skin irritation test (U.S. 49 CFR 173.240) with rabbits (n=6), after a 4-hour occlusive application of this substance, ulceration or necrosis was observed in all animals (REACH registration dossier (Accessed Sept. 2018)). (2) Although the animal species is unknown, this substance is moderately to severely irritating, and signs of necrosis, ulceration and regeneration are reported (PATTY (6th, 2012)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] Severe irritation is reported in animal studies (2) and (3), but based on (1), it was classified in Category 1. [Evidence Data] (1) It was classified in Category 1 for Skin corrosion/irritation. (2) Severe irritation is reported in two eye irritation tests with rabbits (REACH registration dossier (Accessed Sept. 2018)). (3) Although the animal species is unknown, it is reported that this substance is moderately to severely irritating (PATTY (6th, 2012)). (4) Although this substance is judged to be irritating based on an eye irritation test, which reports that keratitis lesions in the corneal epithelial tissue and fibrillary edematous lamellae dissociation were observed (HSDB (2015)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There is no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, it was negative in bacterial reverse mutation tests (PATTY (6th, 2012), REACH registration dossier (Accessed Sept. 2018)). (2) As for in vitro, it was negative in a mammalian cell gene mutation test (PATTY (6th, 2012), REACH registration dossier (Accessed Sept. 2018)). (3) As for in vitro, it was negative in a mammalian cell chromosomal aberration test (REACH registration dossier (Accessed Sept. 2018)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. Although it was classified in Category 2 based on (1) in the previous classification, it was judged that the data was not applicable for classification since it is a test result with only one dose and details including the presence or absence of material toxicity are unknown. [Reference Data, etc.] (1) There is a report that as a result of oral administration to pregnant rats at 157 mg/kg/day throughout the gestation period, disruption of the structure and composition of the liver and structure and growth pattern on the skin were observed in offspring in the administration group (HSDB (2015)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Although the human findings in (1) and (2) are thought to be findings on the isomer mixture, it was judged that this is also applicable to this substance, which is a single isomer. Therefore, it was classified in Category 1 (central nervous system). Besides, the category was changed from the previous classification by using new information sources. [Evidence Data] (1) There is a description that in humans, the main actions reported for simple methyl derivatives of pyridine are local irritation and central nervous system depression (PATTY (6th, 2012)). (2) There is a description that in humans, poisoning symptoms by methylpyridine are weight loss, diarrhea, weakness, ataxia, unconsciousness, central nervous system depression, headache, nausea, and vomiting (HSDB (2015), PATTY (6th, 2012)). [Reference Data, etc.] (3) As for experimental animals, there is a report that in an acute toxicity test in which this substance was administered by gavage to male rats at doses of 550-950 mg/kg, which is within the range of Category 2, in the 950 mg/kg group, 4/10 animals died, and signs of encephalomalacia were observed in 2/6 surviving animals (HSDB (2015)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system, blood system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Although the data in (1) is considered to be the findings on the isomer mixture, it was judged that these are also applicable to this substance, which is a single isomer. And based on the data in (1) and (2), it was classified in Category 1 (central nervous system, hemal system). [Evidence Data] (1) There is a description that in humans, chronic exposure to methylpyridine causes anemia and ocular and facial paralysis in addition to the symptoms of central nervous system depression (HSDB (2015)). (2) There is a report that as a result of inhalation exposure of rats to 5-100 ppm for 6 months, a decrease in the erythrocyte count was observed, which is consistent with the findings in humans. However, it is described that reproducibility was not demonstrated (HSDB (2015)). [Reference Data, etc.] (3) As for experimental animals, in tests in which rats, rabbits and guinea pigs were exposed by inhalation at 25-100 ppm for 6 months, vacuolization of hepatocytes was observed in guinea pigs, but the dose where this was manifested is unclear, and no effects were observed in other animal species (PATTY (6th, 2012), GESTIS (Accessed Sept. 2018)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" from 96-hour LC50 = 897 mg/L for fish (Pimephales promelas) (NLM HSDB: 2018, EPA AQUIRE: 2018, Geiger D. L. et al. (1986)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Chronic toxicity data were not obtained. Although it is not rapidly degradable (not readily degradable, an average degradation rate by BOD: 1% (J-CHECK, 1998)), it was classified as "Not classified" due to no bioaccumulation (LogKow: 1.11 (PHYSPROP Database: 2018)) and because it was classified as "Not classified" in acute toxicity. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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