Item | Information |
---|---|
CAS RN | 109-52-4 |
Chemical Name | valeric acid |
Substance ID | m-nite-109-52-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
Its flash point is 86degC (ICSC (J) (2002)), which is above 60degC and less than 93degC. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Its autoignition point is 400degC (NFPA (13th, 2006)), which is above 70degC. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Since its LD50 = 1844 mg/kg (JECFA (1997)) and 1055 mg/kg (PATTY (5th, 2001) vol.5) for rats, the substance was classified into Category 4. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
Since its LD50 = 660 mg/kg and 290 mg/kg (PATTY (5th, 2001) vol.5) for rabbits, the substance was classified into Category 3. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
Since its LC50 = 4.1 mg/L/2h (2.1 mg/L/4h) for mice (PATTY (5th, 2001) vol.5), which is above its saturated vapour pressure concentration, the test was considered to be conducted in mists, thus, the substance was classified into Category 4. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Since there is a description that, valeric acid is a strong skin irritant in undiluted form (PATTY (5th, 2001)), and valeric acid is rated iC; R34 by EU (EU-AnnexI (accessed August 2008)), the substance was classified into Category 1. As relevant information, it is reported that using mixed isomers of valeric acid demonstrated some tissue necrosis in a 24h rabbit skin irritation assay (PATTY (5th, 2001)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
In an eye irritation test using rabbits, on a scale of 1 to 10, the substance scored 8 (out of a maximum of 10) (HSDB (2006)), and it showed corrosion to skin. Thus, the substance was classified into Category 1. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Since there is no available in vivo test data, classification is not possible. As relevant information, valeric acid was not mutagenic in the in vitro CHO/HGPRT forward mutation assay, and when valeric acid was tested for chromosomal aberrations in vitro using the CHO cell line, increases in aberrations were recorded (PATTY (5th, 2001)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It is reported that an 80-week dermal skin-painting study was conducted with C3H/HeJ mice, and that 50 mg/kg of valeric acid was applied daily. Because of toxicity noted on day 4, doses were reduced to 25 mg/kg, but despite the dose reduction, survival rate reduced substantially, and skin tumors appeared including squamous cell cancer, fibrosarcoma, and fibroma (PATTY (5th, 2001)). Additionally, in a test in which rats were fed a diet containing the substance at 5% concentration, the papillomatous growths in the forestomach was reported (JECFA (1997)). However, both tests used only a single dose, and the transdermal administration test had a problem in that administration doses were inappropriately changed during the test. The rat feeding administration test was performed many years ago (1953), and has no description of such information as the number of animals used or comparison with the control group. Thus, classification is not possible due to lack of data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In tests in which the substance was orally administered to rats during the organogenetic period, no fetotoxicity or effects on development were observed, and no evidence of a teratogenic effect was reported (PATTY (5th, 2001), JECFA (1997)). However, available data on the sexual functions and fertility of parental animals affected by exposure to the substance prior to mating is insufficient, so classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | It is reported that oral administration of the substance did not result in comas in rabbits (PATTY (5th, 2001)), but that intravenous administration of 0.7 or 1.35 g/kg causes moderate CNS depression (PATTY (5th, 2001)). However, since the former test lacks detailed description including doses administered, and the latter provides only intravenous administration data, neither of the results cannot be applied to classification. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a test using rabbits that were transdermally administered with 500 mg/kg/day (90-day conversion: approximately 77 my/kg/day) for two weeks, one died after showing hypopnea and hyperponesis. However, the main finding of the test was severely worsened dermal signs, such as edema, necrosis, and crust. As for systematic toxicity, none except for transient body weight reduction was reported. Accordingly, classification is not possible based only on these data. No other data which can be used as basis for classification has been found. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
Since its 48h-LC50 = 48 mg/L for crustaceans (Daphnia magna) (HSDB, 2006), the substance was classified into Category 3. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Its preexisting classification for acute toxicity is Category 3, it is rapidly degradable (BOD degradability = 87% (HSDB, 2006)), and its potential for bioconcentration is estimated to be low (LogPow = 1.39 (PHYSPROP Database, 2008)). Thus, the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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