NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	109-63-7
Chemical Name	Boron trifluoride diethyl ether; Boron trifluoride ether complex
Substance ID	m-nite-109-63-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since its flash point reported 59 degC (closed-cup) (GESTIS (Access on Oct. 2010)) is >= 23 degC and <= 60 degC, the substance is classified into Category 3. In addition, it is rated as Subsidiary risks Class 3, by the UNRTDG (UN2604).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition temperature is 185 degC (BUA 261 (2005)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	The substance contains the metalloid (boron) and it produces the combustible vapor in reaction with water (Sax (11th, 2004)). Since no data is available, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified	- -	-	-	The substance is an organic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen. Since it is rated as Class 8, PkGI, and Subsidiary risks Class 3 (flammable liquid) by the UNRTDG (UN2604), the substance does not correspond to oxidizing liquid.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data were available. It is considered that the substance is immediately hydrolyzed into ethyl ether (vapor) and boron trifluoride (gas) by moisture in the air. (Merck, 14th (2006), Sax, 11th (2004)). As for the current classification of ethyl ether (liquid) (ID666), it was reported as follows; "Since the lowest rat LD50 value of 1207 mg/kg among 1215 to 2450 mg/kg (DFGOT vol.13 (1999)) and 1207 to 1704 mg/kg (PATTY, 5th (2005)) was adopted for the basis of classification, the substance was classified as Category 4." [Refer also to the classification results of ethyl ether (ID 666) and boron trifluoride (ID 584).]	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1B	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In the rabbit skin irritation test (patch test, exposure time: 1, 5, or 15 minutes or 20 hours, 4 animal/group), necrosis occurred in parts in the 5-minute application group after 24 hours of application. In the 15-minute and 20-hour groups, necrosis extended to the muscle after 24 hours of application (BUA 261 (2005)). Therefore, the substance was classified as Category 1B.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	The substance was classified as Category 1 since the substance was corrosive to the skin. As relevant notes, in the eye irritation test using rabbits (50 microL, instilled into the conjunctiva sac of the one-sided eye of 4 rabbits), nictitating membrane and conjunctiva partly whitened, partly reddened and swollen at 8 days of observation. The cornea was opaque and the iris inflamed. And exophthalmos and partly necrosis of palpebral rims were noted (BUA 261 (2005)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification was not possible due to lack of in vivo test data. As relevant information, as for in vitro study, negative results in the Ames test using bacteria (OECD 471) were reported (BUA 261 (2005)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No substance-specific information was available.　As relevant information, as for the current classification for ethyl ether (liquid), it was reported as follows: "Although maternal toxicity was not described, fetal absorption was observed in rats (IUCLID (2005)), embryonic cleft palates increased in rats (DFGOT vol.13 (1999)), fetal head length decreased in mice (DFGOT vol.13 (1999)), and fetal external, internal and skeletal anomalies were observed in rats and mice (DFGOT vol.13 (1999)). Based on the information, the substance was classified as Category 2."	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No substance-specific information was available.　As relevant information, as for the current classification for ethyl ether, it was reported as follows: "There was no description of toxic symptom in animal tests. There was the respiratory irritation in the case of using it as anesthetics to humans (DFGOT vol.13 (1999), PATTY, 5th (2005), IUCLID (2005)). So it was classified as Category 3 (anesthetic action, respiratory irritation)."　As for the current classification for trifluoroborane (boron trifluoride), it was described as follows. "Based on the descriptions that respiratory irritant, corrosion of the respiratory tract, and pulmonary obstacle (the congestion of lung, pulmonary edemas, pneumonia) were seen in humans (ICSC (J) (1993), HSDB (2005), RTECS (2005)), it was classified as Category 2 (respiratory systems). It was classified as Category 2 (cardiovascular system) based on the description that the cardiovascular system disorders (cardiomyopathy, circulatory shock) were seen in humans (HSDB (2005)). Based on the description that the effect of the nervous system (hyporeflexia, drowsiness, syncope, decreased blood-pressure, hyperpnea, and depression of respiration) were seen in humans (ICSC (J) (1993), HSDB (2005)), the substance was classified as Category 3 (anesthetic action)."	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No substance-specific information was available.　As relevant information, as for the current classification for ethyl ether (liquid), the classification was described as "Not classified". As for the current classification for trifluoroborane, it was described as follows: "Nephrotoxicity, pneumonia, and stimulation of respiratory organs were reported in rats at the dose levels corresponding to Category 1 of the guidance values (50 ppm/6hrs/day) (ACGIH (2001)). Nephrotoxicity, hemorrhage of nasal mucosa/gum, decreased lung function, osteosclerosis, bone fragility, enamel dissolution and fluorosis were reported in humans (ICSC (J), (1993), IUCLID (2000), HSDB (2005)). It was classified as Category 1 (kidney, respiratory system) and Category 2 (bones, tooth) based on these statements."	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 96h-LC50 = 31.6 mg/L for fish (Leuciscus idus) (BUA 261, 2007).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	This substance is thought to be hydrolyzed into mixture of diethyl ether and some acids in environmental water and the aqueous solution becomes strongly acidic, which is considered to be a factor of toxicity. However, this substance is classified as "Not classified" since the toxicity is mitigated in environmental water by buffer action.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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