Item | Information |
---|---|
CAS RN | 109-69-3 |
Chemical Name | 1-chlorobutane; butyl chloride |
Substance ID | m-nite-109-69-3_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Its flash point is 12degC (Ullmanns (E) (6th, 2003)), which is lower than 23degC, and its initial boiling point is above 35degC, given that its boiling point is 78.5degC (Merck (14th, 2006)). Based on this information, the substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Its autoignition point is above 70degC. Regarding its autoignition points documented in literature, they are scattered widely from 240degC (Lide (88th, 2008)) to 460degC (Ullmanns (E) (6th, 2003)) |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing chlorine (but not fluorine or oxygen), which is chemically bonded only to carbon or hydrogen. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Since its rat LD50 is 2670 mg/kg (SIDS (1997)), the substance was classified into the "Not classified" category using the JIS classification criteria (Category 5 in the United Nations classification). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Since its LD50 is > 20 ml/kg or > 17800 mg/kg (SIDS (1997)), the substance was classified into the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Although its rat LCLo is documented to be 8000 ppm/4h (SIDS (1997)), no other data are available for classification. Given that its saturated vapour concentration is approximately 100000 ppm, tests were presumably conducted in a vaporous state. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Skin irritation tests using rabbits (Open Draize tests and standard Draize tests) found that the substance is moderately to highly irritating (SIDS (1997)). Thus, it was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
Eye irritation tests using rabbits (Open Draize tests and standard Draize tests) found that the substance is slightly irritating (SIDS (1997)). Thus, it was classified into Category 2B. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Skin sensitization tests using guinea pigs (OECD TG 406: Buehler tests) found that the substance is not sensitizing (IUCLID (2000)), indicating that the substance falls under the "Not classified" category. However, since these are List 2 studies, the substance was classified into the "Classification not possible" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Six-month chromosomal aberration tests using mouse bone marrow cells (in vivo mutagenicity tests using somatic cells) gave negative results (IUCLID (2000)). Thus, the substance was classified into the "Not classified" category. Regarding in vitro tests, both Ames tests and chromosomal aberration tests using cultured cells of Chinese hamsters gave negative results (NTP DB (accessed in October 2008), Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in October 2008). Mouse lymphoma tests have yielded few positive results (NTP DB (accessed in October 2008)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Not classified |
- |
- | - | In 2-year oral administration tests using rats or mice, survival rates in female and male rats and female mice decreased in the highest dose groups due to mortality caused by convulsions before and after administration. However, incidences of tumorigenesis did not increase in association with the test substance, and thus, no evidence of its carcinogenic effects was found (NTP TR312 (1986)). In EPA's carcinogenicity evaluation, this substance is rated as D (not classifiable as to human carcinogenicity) (IRIS (2005)). Based on these test results and existing classification, the substance was classified into the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In preliminary reproduction toxicity screening tests using rats that underwent oral exposure (OECD TG), though effects of the exposure on sexual functions and fertility in parental animals were not detected, reduced survival rates of offspring during the nursing period as related to high numbers of neonate mortality in the highest dose groups (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in October 2008). In other oral exposure tests conducted during the gestation period, the offspring were crossbred and subsequently evaluated; as a result, embryo mortality increased in the second generation (NTP TR312 (1986)). It is documented that these adverse effects on the offspring occur only at the doses that cause general toxicity in parental animals such as a decreased body weight, or high doses that show strong toxicity. Based on these observations, the substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | To determine the efficacy of this substance as a canine anthelmintic, dogs were orally administered a single dose of the substance; at 0.3 mg/kg (267 mg/kg) or higher doses, lesions of the liver such as fatty infiltration were noted (NTP TR312 (1986)). However, since this study is outdated (conducted in 1932) and was carried out for different purposes, it was not used as grounds for classification. As no other study results are available, classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In reproduction toxicity screening tests using rats that underwent oral administration, no signs of serious toxic effects were noted in males treated with the highest dose of 300 mg/kg/day, other than suppressed body weight gain, reduced food consumption, and salivation being observed (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in October 2008). In addition, in 14-day, 13-week, and 103-week oral administration tests using rats, cases of mortality accompanied with convulsions were detected in the highest dose groups in each study; however, doses of the test substance that fall under the range of guidance values do not show any adverse effects; furthermore, in the 13-week administration study, NOAEL was found to be 120 mg/kg/day (NTP TR312 (1986)). These results indicate that the substance falls under the "Not classified" category (oral route) since administration doses in the range of guidance values did not show adverse effects in treated animals. However, due to lack of test results on other administration routes, the substance was classified into "Classification not possible". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | Since its 96-hour LC50 = 120 mg/L for fish (himedaka), 24-hour EC50 = 380 mg/L for crustaceans (Daphnia magna), and 72-hour EbC50 is > 1000 mg/L for algae (SIDS, 2005), the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Since it is water soluble (water solubility = 370 mg/L (SIDS, 2005), and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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