NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	109-79-5
Chemical Name	1-Butanethiol
Substance ID	m-nite-109-79-5_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of 2 deg C (closed cup) and a boiling point of 98 deg C (ICSC (2000)). Besides, it is classified in Class 3, PG II (UN2347) in UNRTDG.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Classification not possible	- -	-	-	There is only information on an autoignition temperature of below 225 deg C (ICSC (2000)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic substances containing no oxygen, fluorine or chlorine	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to low-temperature-boiling liquids are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on reports of LD50 values of 1,500 mg/kg (SIDS (2012), DFGOT vol. 21 (2005), PATTY (5th, 2001)) and 1,800 mg/kg (DFGOT vol. 21 (2005), PATTY (5th, 2001)) for rats, it was classified in Category 4.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on reports of LD50 values of >2,000 mg/kg for rats (SIDS (2012)) and >34,600 mg/kg for rabbits (DFGOT vol. 21 (2005), PATTY (5th, 2001)), it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on reports of LC50 values (4 hours) of 4,020 ppm (SIDS (2012), DFGOT vol. 21 (2005), ACGIH (7th, 2001), PATTY (5th, 2001)) and 6,060 ppm (SIDS (2012), DFGOT vol. 21 (2005)) for rats, it was classified in Category 4. Besides, since the LC50 values were lower than 90% of the saturated vapor concentration (39,487 ppm), the reference value in units of ppm was applied as a vapour without a mist.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	In skin irritation tests with rabbits, there are reports that after application of 0.5 mL of the undiluted liquid of this substance for 4 hours, no skin reaction occurred (SIDS (2012)), that it was not irritating (PATTY (5th, 2001)), and that it was slightly irritating (PATTY (5th, 2001)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). The category was changed with the revised GHS classification guidance for the Japanese Government.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In eye irritation tests with rabbits, there are reports that mild to moderate irritation of the eyes was observed (ACGIH (7th, 2001)), and that mild to moderate conjunctivitis was observed (PATTY (5th, 2001)). As above, based on a description of "moderate irritation," it was classified in Category 2A.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Category 1B	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1B. Also, based on the new findings, the classification result was changed. [Evidence Data] (1) It was reported that, in a Local Lymph Node Assay (LLNA) (OECD TG 429, GLP) with mice (n=4/group), the Stimulation Index (SI values) were 0.67 (5%), 0.43 (10%), 2.45 (25%), 5.38 (50%), and 14.4 (100%), and the EC3 value was calculated to be 30% (DFG MAK (2019), REACH registration dossier (Accessed Dec. 2021)). [Reference Data, etc.] (2) In the DFG, it was classified in Sh.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There was no in vivo data. As for in vitro, it was all negative in bacterial reverse mutation tests, a mouse lymphoma test and a sister chromatid exchange test with cultured mammalian cells (SIDS (2012), DFGOT vol. 21 (2005), PATTY (5th, 2001)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	In teratogenicity tests with rats through the inhalation route, neither fetal toxicity nor embryotoxicity was observed at doses where maternal toxicities were observed. However, in teratogenicity tests with mice through the inhalation route, death of fetuses and embryos was observed at doses where severe maternal toxicities (death in 8/25 animals) were observed (SIDS (2012), DFGOT vol. 21 (2005), ACGIH (7th, 2001), PATTY (5th, 2001)). The data on mice which supported Category 2 in the previous classification was based on the same experiment as above. In DFGOT vol. 21 (2005), a newly added information source, general toxicities against parental animals were described in detail, and severe maternal toxicities were observed, therefore, they were not used for classification. As above, in teratogenicity tests, no clear effects were observed. However, because no information on fertility was obtained, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects)	Danger Warning	H370 H335 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	This substance was irritating to the respiratory tract (SIDS (2012), ACGIH (7th, 2001)). In humans, in multiple accidental cases, malaise, nausea, headache, vomiting, drowsiness, weakness, coma, muscular weakness, central nervous system suppression, increased rate of breathing, dizziness and mydriasis were reported (ACGIH (7th, 2001)). As for experimental animals, labored breathing, reduced activity, prostration and tremors were observed at 3,870-9,810 ppm (14.9-37.7 mg/L) by 4-hour inhalation exposure of rats. Central nervous system suppression, muscle cramps, uncoordinated movement, cyanosis were observed with 4-hour inhalation exposure of mice at 2,500 ppm (9.6 mg/L). There was a report of restlessness, sedation and incoordination by an oral dose at 1,093-3,344 mg/kg in rats (SIDS (2012), ACGIH (7th, 2001), DFGOT vol. 21 (2005), PATTY (5th, 2001), HSDB (Access on August 2014)). Effects on the central nervous system in experimental animals were observed at concentrations within the guidance value range of Category 1. From the above, it was classified in Category 1 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects). Besides, because "hemolytic anemia in an oral administration test with chickens in PATTY (4th, 1994)" described in the previous classification could not be confirmed, it was not adopted.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There were no hazardous data on humans from repeated exposure. As for experimental animals, in a test in which rats were exposed to the vapour of this substance by inhalation for 13 weeks, increased lung weight (male), increased alveolar macrophages (male and female), and changes in hemal parameters such as decreased red blood cells (female) were observed at the concentration range (0.26-0.55 mg/L/6 hours) corresponding to Category 2. However, it is described that the changes in the hematological test values were not of toxicological significance because of their being within the range of historical control values (SIDS (2012)). In addition, since pulmonary findings included no tissue injuries and no clear organic changes were observed overall in the respiratory tract tissues including the lungs, it was considered that the respiratory organs were out of the target organs. Therefore, from this test, it was not possible to identify the target organs to use for classification. On the other hand, there were no available data through the oral route (SIDS (2012)). Thus, classification was not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 96-hour EC50 = 1068300 ug/L for algae (Pseudokirchneriella subcapitata) and 96-hour LC50 = 1100000 ug/L for fish (Ictalurus punctatus) (both AQUIRE, 2015).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 597 mg/L, PHYSPROP Database, 2009) and was classified as "Not classified" in acute toxicity.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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