NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	110-82-7
Chemical Name	Cyclohexane
Substance ID	m-nite-110-82-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	From a flash point of -18 deg C (closed cup) and a boiling point of 81 deg C (ICSC (2011)), it was classified in Category 2. Besides, it is classified in Class 3, PG II (UN1145) in UNRTDG.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 260 deg C (ICSC (2011)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" from 5 LD50 values for rats of > 5,000 mg/kg, 6,240 mg/kg, 12,870 mg/kg, 29,800 mg/kg, and 30,420 mg/kg (EU-RAR (2004)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on the description that no death was observed at 2,000 mg/kg in rabbits (EU-RAR (2004)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	It was classified as "Not classified" based on 4-hour exposure LC50 of > 9,500 ppmV (32.88 mg/L) for rats (EU-RAR (2004)). Besides, because the concentration of test substance was lower than 90% [113,169 ppmV (132.4 mg/L) ] of the saturated vapour pressure concentration (125,743 ppm), a reference value in the unit of ppmV was applied as a vapour without a mist.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It is described that it was irritating to the skin in rabbits and humans (DFGOT vol. 13 (1999), EU-RAR (2004), ACGIH (7th, 2002), ICSC (J) (1994)). It is described that repeated administration to rabbits produced cracked skin and bleeding, but these disappeared one week after the administration (DFGOT vol. 13 (1999)), and the 1-hour application of the undiluted substance to humans produced erythema and wheal formation (EU-RAR (2004)), which are also thought to be reversible disorder. It was classified in Category 2 from the above data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It is described that corneal opacity, iritis, and conjunctival redness/chemosis were observed in rabbits, and all of these were reversible (EU-RAR (2004)), and that it was irritating to the eye in animals and humans (PATTY (6th, 2012), EU-RAR (2004), ICSC (J) (1994), HSDB (Access on July 2013)). Therefore, it was classified in Category 2.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a chromosomal aberration test with rat bone marrow cells (EU-RAR (2004), DFGOT vol. 13 (1999), IRIS (2003), PATTY (6th, 2012), IUCLID (2000)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test (EU-RAR (2004), DFGOT vol. 13 (1999), IRIS (2003), PATTY (6th, 2012), IUCLID (2000), ACGIH (7th, 2002)) and a mouse lymphoma test with cultured mammalian cells (EU-RAR (2004), DFGOT vol. 13 (1999), IRIS (2003), PATTY (6th, 2012), IUCLID (2000)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because EPA classified it in I (IRIS (2003)). The category was changed according to the revised GHS classification guidance for the Japanese government.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Not classified	- -	-	-	In a two-generation test with rats by inhalation exposure, even at the dose which produced severe general toxicity effects (reduced weight gain, decreased food consumption) in parent animals, no fertility effects were seen in parent animals, and only minimum effects (decreased pup weights) were observed in offspring (EU-RAR (2004), ACGIH (7th, 2002)). And in a developmental toxicity test in which pregnant rats were exposed by inhalation, no effects occurred in fetuses even at the doses where maternal toxicity (reduced weight gain, decreased food consumption, diminished response to a sound stimulus) was found (EU-RAR (2004), ACGIH (7th, 2002)). From the above, it was classified as "Not classified" according to the GHS classification guidance for the Japanese government.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 2 (cardiovascular system), Category 3 (respiratory tract irritation, narcotic effects)	Warning	H371 H335 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	Signs of central nervous system depression from inhalation exposure are reported in many kinds of animal species (ACGIH (7th, 2002)), and it is thought to cause narcotic effects, but exposure concentrations are unclear. It was classified in Category 2 (vascular system) because it is described that after oral administration to rabbits, the vascular injury was observed at the dose within the guidance value range for Category 2 (ACGIH (7th, 2002)). Furthermore, It was classified in Category 3 (respiratory tract irritation, narcotic effects) based on the description that it was irritating to the respiratory tract in humans (ACGIH (7th, 2002)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There are no descriptions that the toxicity of this substance occurred in humans (ACGIH (7th, 2002), EU-RAR (2004), PATTY (6th, 2012)), and in experimental animals, no toxicity was observed at the doses within the guidance value range for Category 2 in 10-14-week inhalation toxicity tests (mice, rats, rabbits) (minimum concentration that produced toxicity: 786 ppm (converted guidance value concentration: 2.08 mg/L/6 hours)) (ACGIH (7th, 2002), EU-RAR (2004), PATTY (6th, 2012)). Therefore, it falls under "Not classified" in the inhalation route, but there is no toxicity information on the other routes, Therefore, the classification is not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it may be fatal when swallowed this substance (liquid), and it enters the airway by aspiration (ICSC (J) (1994)). The category was changed according to the revised GHS classification guidance for the Japanese government.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour EC50 = 0.9 mg/L for crustacea (Daphnia magna) (EU-RAR, 2004), it was classified in Category 1.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified in Category 3 due to rapid degradability (a 28-day degradation rate by OECD Test Guideline 301F: 77% (EU-RAR, 2004)), and 72-hour NOEC = 0.94 mg/L for algae (Pseudokircheneriella subcapitata) (EU-RAR, 2004). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, there are data: 48-hour EC50 = 0.9 mg/L for crustacea (Daphnia magna) (EU-RAR, 2004). However, it is rapidly degradable (a 28-day degradation rate by OECD Test Guideline 301F: 77% (EU-RAR, 2004)), and low bioconcentration is estimated (BCF = 31-129 (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1984)). Therefore, it is classified as "Not classified." By drawing a comparison between the above results, it was classified in Category 3.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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