Item | Information |
---|---|
CAS RN | 110-97-4 |
Chemical Name | 1,1'-iminodipropan-2-ol; di-isopropanolamine |
Substance ID | m-nite-110-97-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Its autoignition point is 290degC (Ullmanns (E) (2003)), which is above 70degC. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140degC) substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Its rat LD50 of 4765 mg/kg (PATTY (5th, 2001)) falls under the "Not classified" category using the JIS classification criteria (Category 5 in the United Nations classification). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Its LD50 of 16000 mg/kg for rats (IUCLID (2000)) and 8000 mg/kg for rabbits (IUCLID (2000)) both fall under "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
There are several reports that the application of the substance to abraded or intact sites of rabbit skin caused moderate or slight hyperemia (IUCLID (2000); HSDB (2006)), or the application to abraded sites caused moderate denaturation (IUCLID (2000); HSDB (2006)). Furthermore, in Draize tests using rabbits, application of undiluted test substance to intact sites on the abdomens of rabbits caused irreversible, severe necrosis at several sites (HSDB (2006)). Thus the substance was classified into Category 1. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
In rabbit tests, the substance was found to cause moderate to severe eye irritation (IUCLID (2000)) or chemical burns (IUCLID (2000); HSDB (2006)), and these symptoms underwent spontaneous recovery within 22 days (HSDB (2006)). It is rated as Xi, R36, which falls under Category 2 guidance values. Thus, the substance was classified into Category 2A. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Not classified |
- |
- | - | In guinea pig tests, the application of the substance caused a weak allergic effect (IUCLID (2000)). On the other hand, In Draize tests in which humans were applied with 2% aqueous solution, no induction of immune response was detected (IUCLID (2000)). In addition, in the study in which sun-protection cream containing 1% diisopropanolamine was applied to 203 volunteers, sensitizing reaction was induced only in one volunteer. Based on these results, the substance was classified into the "Not classified" category (HSDB (2006)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Since there are no in vivo mutagenicity test results using germ or somatic cells, or no positive results in in vitro mutagenicity tests using several indices, classification is not possible. Both Ames tests (PATTY (5th, 2001); NTP DB (accessed in November 2008)) and chromosomal aberration tests using rat lymphocytes (IUCLID (2000)) gave negative results. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | In 94-week oral administration (mixed diet) tests using rats, no increase in incidences of tumorigenesis was noted (IUCLID (2000)). However, since there are no test data using animals other than rats, classification is not possible due to insufficient data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | In oral administration tests using rats, mice, guinea pigs, or rabbits, hypoactivity and hypothermia were noted (IUCLID (2000)); however, toxic doses were not provided. Thus, classification is not possible due to insufficient data available. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In the 2-week oral administration study through drinking water using rats (doses: 100, 300, 600, 1200, and 3000 mg/kg), degeneration of kidney was noted at 3000 mg/kg, which fall under the "Not classified" category guidance values (IUCLID (2000)). In 94-week mixed diet administration tests using male rats, no clinical or pathological cases were detected at doses (392-843 mg/kg) above the range of guidance values (IUCLID (2000)); however, this study involved only male rats and one dose. Thus, the substance was classified into "Classification not possible" due to insufficient data available. As additional notes, in 4-week dermal administration tests using rats, no pathological changes were noted other than slight abnormalities found in applied areas with doses that are above the range of guidance values (IUCLID (2000)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | Its 96-hour LC50 is > 1000 mg/L for fish (zebra fish), 48-hour EC50 = 277.7 mg/L for crustaceans (Daphnia magna), and 72-hour EC50 = 270 mg/L for algae (Scenedesmus) (IUCLID, 2000). Based on these LC50 values, the substance was classified into the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Since it is water soluble (water solubility = 870000 mg/L (PHYSPROP Database, 2008)) and its classification for acute toxicity is the "Not classified" category, the substance was classified into the "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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