Item | Information |
---|---|
CAS RN | 11097-69-1,1336-36-3,53469-21-9 |
Chemical Name | PCB 1254; polychlorobiphenyl; Chlorodiphenyl (42% chlorine) |
Substance ID | m-nite-11097-69-1_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified |
- |
- | - | Flash point: >93degC, Non-combustible (ICSC(J), 1999). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Not combustible (ICSC (J) (1999) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Not combustible (ICSC(J) (1999)) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Containing no -0-0- structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Not classified |
- |
- | - | UNRTDG Class: 9 | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Calculated based on rat LD50 value of Aroclor 1254: 1010mg/kg (CICAD 55, 2003, ATSDR, 2000, PATTY 4th, 1994, EHC 140, 1992), 4000mg/kg (IARC 18, 1978, EHC 140, 1992), 1300mg/kg (IARC 18, 1978, EHC 140, 1992), 1400mg/kg (EHC 140, 1992), and 2000mg/kg (IARC 18, 1978, EHC 140, 1992). The calculated values became 1057mg/kg, and it was set as Category 4. Classified based on the toxic value of Aroclor 1254, because the toxic value of Aroclor 1254 was lower than Aroclor 1242. (About Aroclor 1242, it is in Category 5 based in rat LD50 values: 4250mg/kg (CICAD 55, 2003, ATSDR, 2000, EHC 140, 1992) and 8700mg/kg (IARC 18, 1978)) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
It was set as Category 3 based on rabbit percutaneous LD50 (MLD): 800mg/kg (EHC 140, 1992, ATSDR, 2000, IARC 18, 1978). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Since data is insufficient, it cannot be classified. Skin pathological changes, such as chloracne, were caused in the human occupational exposure (exposure to vapor). But there was no data about the stimulativeness at the time of the direct skin contact. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | There is description that eye irritation is acknowledged in human occupation evidence of exposure (exposure to vapor) (ATSDR (2000) and EHC 140 (1992)). But there is no animal examination data or human case report which attached PCB to eye surface directly. So it cannot be classified due to insufficient data. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | The substance was regarded as outside the categories. Because of the negative results from the dominant lethal tests in rats (ATSDR, 2003, IARC 18, 1978, EHC 140, 1992), from chromosome aberration tests in mammalian spermatogenic cells (CICAD 55, 2003, ATSDR, 2000, IARC 18, 1978, EHC 140, 1992), and from the chromosome aberration tests and micronucleus tests using mammalian bone-marrow cells (CICAD 55, 2003, ATSDR, 2000, IARC 18, 1978, EHC 140, 1992, NTP DB, Access on Oct 2005). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
It is classified into A3 according to ACGIH (7th, 2001) and is classified into B2 according to EPA (IRIS, Access on Oct 2005). But it is classified into 2A according to IARC (Access on Oct 2005) and into 2A according to Japan Society for Occupational Health (2005), and classified into R according to NTP (11th, 2005). So it was set as Category 1B. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Category 1A |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
There is the description that there were the female reproductive toxicity such as menstrual irregularity, the decrease of reproductive potential of male, and fetal growth abnormality in the human exposure (CICAD 55 (2003), PATTY (4th, 1994), IARC 18 (1978), and ATSDR (2000)), it is classified into Category 1A. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
Due to the description that respiratory irritant is observed in human in ACGIH (7th, 2001), ATSDR (2000), and EHC 140 (1992), it is judged that it has respiratory irritant and it was classified into Category 3. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, skin, immune system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Due to the descriptions that in human exposure example, hepatic dysfunction (ACGIH 7th, 2001, PATTY 4th, 1994, IARC 18, 1978, EHC 140, 1992 and ATSDR, 2000), skin condition, such as chloracne (CICAD 55, 2003, ACGIH 7th, 2001, PATTY 4th, 1994, IARC 18, 1978, EHC 140, 1992 and ATSDR, 2000), and immune dysfunction (CICAD 55, 2003, EHC 140, 1992, ATSDR, 2000) were observed, it is considered that target organs were liver, the skin, and an immunity system and they all were classified into Category 1. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified into Category 1 from 96-hour LC50=0.008mg/L of fishes (Fathead minnows) (EHC140, 1993). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1, since acute toxicity is Category 1, stable in environmental, not rapidly degrading and bioaccumulative (BCF=270000 (EHC140, 1993)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|