NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	111-36-4
Chemical Name	1-Isocyanatobutane
Substance ID	m-nite-111-36-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	A flash point of 19 degrees C [closed cup] [Hommel (1996)] is < 23 degrees C, and an initial boiling point of 116 degrees C [Ullmanns (E) (2003)] is > 35 degrees C, therefore it corresponds to Category 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing neither chemical groups related to explosibility nor those related to self-reactivity.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is conceivable that it does not ignite at normal temperatures from an ignition point of 425 degrees C [Hommel (1996)].	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	An organic compound that contains oxygen which is not chemically bonded to elements other than carbon.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data. Besides, stainless steel, nickel, and aluminum are durable as a container (Hommel (1996)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	All of three LD50 values for rats (360, 600, 400-1600 mg/kg) (SIDS (2005)), which are subjects for classification, correspond to Category 4.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	The lowest dose of 700 mg/kg at which one or more animals died in a rabbit test was reported (SIDS (2005)), but the classification is not possible because the category can not be determined only from this data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	On the basis of an LC50 value of 0.059 mg/L/4h (14.55 ppm V/4h) for rats (OECD TG403; GLP compliance) (SIDS (2005)), it was classified in Category 1. Besides, a reference value of gasses was applied because the toxicity value (14.55 ppm) is lower than 90 % of the saturated vapour pressure concentration (23158 ppm).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	After occlusive application of 0.5 mL of an undiluted test substance to rabbit ears for 15 or 30 minutes, effects became more serious and the skin was perforated in 1 to 2 days. Surface skin scaling was observed at the end of observation period of 7 days. On the basis of the evaluation as "highly corrosive" (SIDS (2005)), it was classified in Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Immediately after application of 0.1 mL into a conjunctival sac of rabbits, strong erythema with pronounced chemosis which remained unchanged until the end of the observation period of 7 days. The evaluation of the cornea, which showed diffuse opacity, was restricted to the first day of the observation period. Afterwards, cornea and iris could not be examined due to edema of the conjunctiva. On the basis of the evaluation as "highly corrosive" (SIDS (2005)), it was classified in Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data. Besides, a report in which a challenge reaction was temporary and not severe after inducing with a conjugated form of bovine serum albumin and butyl isocyanate after inhalation exposures to guinea pigs (SIDS (2005)) is not used as a basis for classification because it is considered not to be an appropriately established animal model for a respiratory sensitization test at this time.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	On the basis of a report of a guinea pig maximization test which results in "sensitizing" with 100% positive rate from 15/15 with distinct erythema and slight edema in several animals after challenges (SIDS (2005)), it was classified in Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible because there are no in vivo test data. Besides, a negative in an Ames test and a positive in a germ cell mutagenicity test using L5178Y mouse lymphoma cells are reported as in vitro tests (SIDS (2005)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Rats dose-dependently showed clinical signs indicating respiratory tract irritation such as bradypnea, dyspnea, labored breathing, and cyanosis by an inhalation exposure at concentrations of 0.007 mg/L/4h (vapour) or higher. Addition to an occurrence of deaths at 0.056 mg/L/4h (vapour) or higher, significant gross findings in the lungs such as pulmonary edema and hydrothorax observed in necropsy were the only macroscopic detectable effects at the end of the post-observation period (SIDS (2005)). Also, another inhalation test exposed 0.008 to 0.050 mg/L/4h to rats reported that effects on respiratory tracts were mainly observed, animals died due to respiratory tract lesions at 0.050 mg/L/4h, the prominent microscopic changes such as an increased number of macrophages, perivascular round-cell infiltration, focal fibroproliferative reactions, emphysema, thickening of septa, and abscessive pneumonia were observed at concentrations of 0.025 mg/L/4h or higher, and bradypnea and mucous membrane irritation were observed at 0.008 mg/L/4h (SIDS (2005)). From the above, it was classified in Category 1 (respiratory system) because a target organ is a respiratory system including respiratory tracts and lungs, and test concentrations were within a value range of Category 1 in Guidance. Besides, symptoms which are relevant to a respiratory system such as labored breathing and cyanosis were observed at doses of 200 mg/kg or higher in a single dose oral administration test to rats (SIDS (2005)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Lack of data. Besides, a report in which an inhalation exposure of 1 to 25 mg/m3 concentrations to male rats showed no significant toxicity effects in 5 mg/m3 but showed changes in biochemical and cellular components in bronchoalveolar lavage fluid in 5 mg/m3 or higher as evidence of inflammations of respiratory tracts is not used as a basis for classification due to a short exposures period as 5 days (SIDS (2005)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 96-hour LC50 = 24 mg/L for fish (Menidia beryllina) for a hydrolysate (n-butylamine) (SIDS, 2008), it was classified in Category 3.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It is classified as "Not classified" due to rapid degradability (a degradation rate by OECD TG302D: 62 %, a degradation rate of a hydrolysate by OECD TG301C: 85 % (SIDS, 2005)), a low bioaccumulation estimate from a hydrolytic property (SIDS, 2008), and no bioaccumulation of the hydrolysate (BCF: 4.1 (SIDS, 2008)), despite acute toxicity Category 3.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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