Latest GHS Classification Results by the Japanese Government (edited by NITE)

Japanese



GENERAL INFORMATION
 
Item Information
CAS RN 111-40-0
Chemical Name N-(2-Aminoethyl)-1,2-ethanediamine; Diethylenetriamine
Substance ID m-nite-111-40-0_v1
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) To Guidance List
UN GHS document (External link) To UN GHS document
FAQ(GHS classification results by the Japanese Government) To FAQ
List of Information Sources (Excel file) List of Information Sources
List of Definitions/Abbreviations Definitions/Abbreviations
Sample Label by MHLW (External link) MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) To OECD/eChemPortal (External link)

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2 Flammable gases Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5 Gases under pressure Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6 Flammable liquids Not classified
-
-
- - A flash point is 97 deg C (closed cup) (ICSC (1996)) above 93 deg C. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7 Flammable solids Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8 Self-reactive substances and mixtures Not classified (Not applicable)
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 358 deg C (ICSC (1996)). FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10 Pyrophoric solids Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14 Oxidizing solids Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16 Corrosive to metals Classification not possible
-
-
- - No data available. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17 Desensitized explosives -
-
-
- - - - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on LD50 values of 1,080 mg/kg (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), PATTY (6th, 2012)), about 1,140 mg/kg, 1,539 mg/kg, about 1,800 mg/kg, and 1,950 mg/kg (SIDS (2002)) in oral administration tests with rats. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1 Acute toxicity (Dermal) Category 4


Warning
H312 P302+P352
P362+P364
P280
P312
P321
P501
LD50 values in dermal administration tests with rabbits are about 672 mg/kg, 1,040 mg/kg (SIDS (2002)), and 1,090 mg/kg (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)), one corresponds to Category 3, and two correspond to Category 4. According to the revised GHS classification guidance for the Japanese government, it was classified in Category 4 to which most data corresponded. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1 Acute toxicity (Inhalation: Gases) Not classified (Not applicable)
-
-
- - Liquid (GHS definition) FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, the result in the Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), the rationale for the previous classification, was not adopted because it was LDLo. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
Strong corrosivity or corrosivity is described as health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)) and the results of skin irritation tests with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)). Furthermore, this substance is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Strong irritation, high corrosivity, or loss of vision is described as data on health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), ACGIH (7th, 2001)) and the results of administering the undiluted substance in eye irritation tests with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)). Furthermore, this substance is a skin irritant and is classified in "C; R34" EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4 Respiratory sensitization Category 1


Danger
H334 P304+P340
P342+P311
P261
P284
P501
As data on health effects in humans, it is described that asthma-like allergic reactions in the respiratory tract from occupational exposure are reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002), ACGIH (7th, 2001)), therefore it was considered to cause respiratory sensitization, and it was classified in Category 1. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
It was considered to be sensitizing to the skin because of a positive result in a maximization test with guinea pigs (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)), reports that positive results were observed in patch tests in workers handling this substance, etc. (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002), ACGIH (7th, 2001)). Furthermore, this substance is classified in "R43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification. It was classified in Category 1 based on the above information. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), SIDS (2002)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), SIDS (2002)). FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6 Carcinogenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not classified by other organizations, and there is toxicity information but no reliable information. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7 Reproductive toxicity Category 1B


Danger
H360 P308+P313
P201
P202
P280
P405
P501
It is described in the Initial Risk Assessment Report (NITE, CERI, NEDO, 2005) and Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013) that in a reproduction/developmental toxicity screening test with rats (OECD TG 421), reproductive and developmental effects (extension of a gestation period, increased embryonic/fetal death, etc.) were observed at the dose where no other toxicity signs were seen in parent animals. Therefore, it was classified in Category 1B according to the GHS classification guidance for the Japanese government. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
11 Hazardous to the aquatic environment Short term (Acute) Category 3
-
-
H402 P273
P501
From 48-hour EC50 = 16 mg/L for crustacea (Daphnia magna) (SIDS, 2002), it was classified in Category 3. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11 Hazardous to the aquatic environment Long term (Chronic) Not classified
-
-
- - If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 21-day NOEC = 5.6 mg/L for crustacea (Daphnia magna) (SIDS, 2002).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 96-hour LC50 = 248 mg/L for fish (Leuciscus idus) (SIDS, 2002).
From the above results, it was classified as "Not classified."
FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol. FY2013 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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