NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	111-69-3
Chemical Name	Adiponitrile
Substance ID	m-nite-111-69-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified	- -	-	-	Flash point 159 degC (closed-cup) (ICSC (1995)), 163 degC (Hommel (1996)) are 110 degC. Information is available that flash point of industrial product is 93 degC (open-cup) (Hommel (1996)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified	- -	-	-	Auto-ignition point is 550 degC (ICSC (1995), NFPA (13th, 2006), HSDB (2009)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	LD50 values are 138 mg/kg, 300 mg/kg (SIDS (access on May 2009)), 155 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of Environment) vol. 3 (2004)) and 500 mg/kg (ACGIH (2001))) for rats. Since three values correspond to Category 3, the substance was classified into Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	LD50 values are 800 mg/kg (ACGIH (2001)) and >2000 mg/kg (SIDS (access on May 2009)) for rabbits. The category with higher hazard was adopted and the substance was classified into Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on LC50 values of 1.71 mg/L/4h (SIDS (access on May 2009), Initial Environmental Risk Assessment of Chemicals (Ministry of Environment) vol. 3 (2004)) and 3 mg/L/4h (ACGIH (2001)) for rats, the substance was classified into Category 4. The tests were conducted at concentrations higher than saturated vapour pressure concentration.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on a result of "no irritation" in a rabbit skin irritation test (ACGIH (2001)), the substance was classified as "Not classified". As relevant information, seven cases of skin exposure were reviewed. Six of the cases resulted in skin irritation and inflammation, 5 to 15 minutes following exposure. In the seventh case, a worker suffered extensive destruction of the skin on one foot after his shoe was drenched with the substance. He was incapacitated for 117 days (ACGIH (2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on a result of "slightly irritating" during 8-day observation period in a rabbit test (SIDS (access on May 2009), IUCLID (2000)), the substance was classified into Category 2B.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Not classified	- -	-	-	Based on negative results in a guinea pig skin sensitizing test (SIDS (access on May 2009), ACGIH (2001), IUCLID (2000)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in a rat bone marrow chromosomal aberration test (in vivo somatic cell mutagenicity test) (SIDS (access on May. 2009), IUCLID (2000)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test (ACGIH (2001), SIDS (access on May. 2009)), a negative mouse lymphoma test (SIDS (access on May. 2009)) and a negative rat hepatic cell unscheduled DNA synthesis test (SIDS (access on May. 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	Based on the classifications of "D" (not classifiable as to human carcinogenicity) in EPA (1991), the substance was classified as "Not classified". In a 2-year drinking test in rats (ACGIH (2001)), there were no increases in tumor incidence.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Not classified	- -	-	-	In a 3-generation reproductive test in rats administered in drinking water, no effect upon the indices of fertility, gestation or viability was observed (ACGIH (2001)). In inhalation exposure tests, female rats exposed for 22 days were mated to unexposed males and male rats exposed for 74 days were mated to unexposed females. In both cases, sexual function and reproductive performance were unaffected (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). In a developmental toxicity test in rats by gavage on gestation days 6 - 19, 1 and 2 dams died in the middle and high dose groups, respectively. No adverse effects were observed on fetal development including teratogenicity (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). Based on the data, the substance was classified as "Not classified" since there were no adverse effects on parental sexual function and fertility and fetal development.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There is a case report of an accidental swallowing of a few mL of the substance in which vomiting, chest tightness, weakness, dizziness and cyanosis appeared within 20 minutes. Following the initial symptoms, tachycardia, tachypnea, decreased blood pressure, mydriasis, tonic/clonic contraction of limb and facial muscles and confusion were also observed (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004), PATTY (5th, 2001)). Most victims of acute poisoning either die acutely or recover fully. In rare incidents, cases of neurological sequelae such as personality changes, memory deficits, and extrapyramidal (Parkinsonian-like) syndromes were reported (HSDS (2009)). Based on the data, the substance was classified into Category 1 (nervous system). In animal inhalation tests, increased respiration, sluggish movement and slight cyanosis were seen in mice (ACGIH (2001)), and convulsion and lethargy were seen in rats (Hazard Data Book for Chemical Substance (CERI) 2001-17 (2002)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood)	Warning	H373	P260 P314 P501	In a 4-week inhalation exposure test in rats, more than half of the animals died at 493 mg/m3, and decreases in mean cell hemoglobin concentration (MCHC), hemoglobin concentration and hematocrit, hemosiderin pigmentation and extramedullary hematopoiesis in the spleen were observed at 114 mg/m3 (90-day equivalent: 0.035 mg/L) and higher levels (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). Additionally, in a 13-week inhalation exposure test, anemia was observed at 0.99 mg/L (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)), and in a dermal test with guinea pigs, hyperchromic anemia was observed after 3 to 16 doses (ACGIH (2001)). Nylon workers were reported to exhibit a tendency to hyperchromic anemia of the hemolytic type, slight leukopenia, and sometimes lymphomonocytosis following exposure to the substance. However, this human exposure was to a mixture of substances and there is not enough data presented to reach any clear-cut conclusion as to the relationship with the substance (ACGIH (2001)). Insufficient data was obtained for humans from these reports. Based on the animal data, the substance was classified into Category 2 (blood system). In a 2-year drinking water test in rats, degeneration in the adrenal gland was noted in the males (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)), however, this data was not used as the basis of classification since it is from a 2-year test and a similar finding was not observed in a 13-week test.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Classified into Not classified from its 96h-LC50 = 670 mg/L for fish (Rainbow trout) (SIDS, 1998), 24h-EC50 = 445 mg/L for Crustacea (Daphnia magna) (SIDS, 1998) and 96h-EC50 >100 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 1998).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble (Water solubility = 80000 mg/L (PHYSPROP Database, 2009).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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