Item | Information |
---|---|
CAS RN | 111-70-6 |
Chemical Name | 1-Heptanol |
Substance ID | m-nite-111-70-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
Since its flash point reported 70 degC (closed-cup) (ICSC (2005)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Since its autoignition temperature is 275 degC (ICSC (2005)), it is considered that the substance does not ignite at room temperature. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the rat LD50 values of 6.2 g/kg (male), 5.5 g/kg (female) and 3.25 g/kg (PATTY, 5th (2001)), the substance was classified as "Not classified". | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the rabbit LD50 values of approximately 2 g/kg and > 5 g/kg (PATTY, 5th (2001)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 or "Not classified" in the UN-GHS classification). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No death for 4-hour exposure of the saturated vapor was reported (PATTY, 5th (2001)). Since the report did not provide the basis for classification, the classification was not possible. The saturated vapor pressure concentration at 25 degrees centigrade is 1.35 mg/L. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Insufficient data were available. Although the mouse LC50 value of 6.6 mg/L (1390 ppm) was reported (PATTY, 5th (2001)), the exposure time was unknown, and the classification was not possible. The LC50 value was higher than the saturated vapor pressure concentration (1.35 mg/L), the criterion value for dust/mist were adopted. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
The substance was classified as Category 2 based on the documented case of "moderately irritating" resulted from the rabbit test in which undiluted substance was applied for 24 hours (PATTY, 5th (2001)). As relevant notes, it was reported that the occlusive application of 1% of the substance in petrolatum for 48 hours caused no irritation to human skin (PATTY, 5th (2001), original literature: D. L. J. Opdyke, Food Cosmet. Toxicol.13, p 697-698 (1975)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
The substance was classified as Category 2 based on the documented case of "moderately irritating" resulted from the rabbit test (PATTY, 5th (2001)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | In the human maximization test with 20 volunteers, the substance didn't cause skin sensitization (PATTY, 5th (2001)). However, no further information or details of the test were provided in the original report (Food Cosmet. Toxicol. 13, 697-698 (1975)). Thus, the substance was classified as "Classification not possible". | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification was not possible due to lack of in vivo test data. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | The classification was not possible due to lack of data. As relevant information, there was a description referring to the NOEL of 50 mg/kg, the highest dose in the 6-month oral toxicity study in rabbits (JECFA FOOD ADDITIVES SERIES 40 (1998)). In the inhalation study in rats and rabbits, conjunctival redness and decrease in blood cholinesterase activity were observed. And it was also reported that inhalation of 0.18 - 0.35 mg/L (38 - 74 ppm) 2hrs/day for 4.5 months caused minor hematologic changes and some unspecified histological changes (PATTY, 5th (2001)). However, there were no concrete descriptions in these data regarding the concentrations and duration of the exposure, or the animal species tested. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Based on the fact that the substance is a n-primary alcohol with carbon numbers C3 to C13 and coefficient of kinematic viscosity is 7.1 mm2/s (coefficient of viscosity: 5.81 mPa*s (25 degrees centigrade), density: 0.822 g/cm3 (Lide, 90th (2009)), the substance is classified as Category 2 of the UN-GHS criteria. However, the classification was not possible by the JIS classification criteria. Additionally, as related information, it was reported that inhalation of 0.2 mL of this substance caused instant death of 10/10 rats due to respiratory failure (PATTY, 5th (2001)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
Classified into Category 3 from its 96h-LC50 = 18 mg/L for fish (Oryzias latipes) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2000). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
Classification using chronic toxicity data: although adequate data on rapid degrability are not available, the substance is classified as "Not classified" from 21d-NOEC = 1.4 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2000). Classification using acute toxicity data for the trophic levels for which chronic toxicity data are lacking: although adequate data on rapid degradability are not available, the substance is classified into Category 3 from 96h-LC50 = 18 mg/L for fish (Oryzias latipes) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2000). The substance is classified into Category 3 by comparing the outcomes mentioned above. |
FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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