NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	111-71-7
Chemical Name	Heptanal
Substance ID	m-nite-111-71-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	A flash point of 48 degrees C [closed cup] (HSDB (2009)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3. Besides, it is classified in 3PGIII in UNRTDG (3056).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing neither chemical groups related to explosibility nor those related to self-reactivity.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is conceivable that it does not ignite at normal temperatures from an autoignition temperature of 250 degrees C (HSDB (2009)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	An organic compound that contains oxygen which is not chemically bonded to elements other than carbon.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	On the basis of an LD50 value of > 5000 mg/kg bw for rats (USEPA/HPV (2004), equivalent to List 1), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	On the basis of an LD50 value of > 5000 mg/kg bw for rabbits (USEPA/HPV (2004)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	It was classified as "Classification not possible" because the category cannot be determined from an LC50 value of > 4.7 mg/L/4 h for rats (> 1006.7 ppm/4h) (USEPA/HPV (2004)). Besides, a reference value of gasses as vapour with hardly included mist is applied because the test concentration (1006.7 ppm) is lower than 90 % of the saturated vapour pressure concentration (4632 ppm).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	On the basis of a Primary Irritation Index (PII) of 5.0 in a test (OECD TG 404, GLP compliance), in which moderate erythema and slight oedema were observed until 7 days after the application of 0.5 mL of an undiluted test substance solution to rabbit skins for 4 hours (ECETOC TR 66 (1995)), it was classified in Category 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	On the basis of a report of Draize test using rabbits, all of which were completely recovered from the observed changes such as ulceration in the cornea in 4 out of 6 rabbits, iritis in 5, and ulceration in conjunctiva in 5 within 7 days (IUCLID (2000)), it was classified in Category 2B.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	A maximization test using 25 humans reported that this substance produced no contact-sensitization (HSDB (2009)). Besides, positive responses in a guinea pig maximization test, which were shown in 4 out of 18 animals 24 hours after a challenge procedure and were shown in 3 out of 18 animals after 48 hours (HSDB (2009)), were below 30 % of criteria. But it was classified as "Classification not possible" due to information from List 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo data. Besides, a negative in an Ames test (NTP DB (1987)) and a negative in a forward mutation test using mouse lymphoma (USEPA/HPV (2004)) were reported respectively as in vitro tests. In addition, a negative result was reported in a micronucleus test in which 2,6-dimethyl-5-heptanal as structurally related aldehyde was administrated to mice by intraperitoneal injection (an in vivo somatic cell mutagenicity test) (USEPA/HPV (2004)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	A reproduction test reports that no evidence of reproductive toxicity was found in female rats in oral administration of this substance at 2050 mg/kg/day. But a number of parameters measuring reproduction are limited, and quality and reliability of data are uncertain (USEPA/HPV (2004)). Therefore, it was classified as "Classification not possible" due to lack of data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	No deaths were shown by inhalation exposure at a concentration of 4.7 mg/L for 4 hours, but weight gains were observed during the week after exposure, and symptoms such as labored breathing, gasping, dry rales and nasal discharge were shown (HSDB (2009)). Therefore, it was classified in Category 3 (respiratory tract irritation).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	A 29-day gavage administration test to rats reports hypertrophy of hepatocyte, decreased periportal cavitation, increased liver weight accompanied by increased cytoplasmic density at doses of 1500 mg/kg/day or higher, no significant signs related to dosing at a dose of 300 mg/kg/day, and a NOAEL of 300 mg/kg/day (USEPA/HPV (2004)). The dose of 300 mg/kg/day (converted to a 90-day equivalent value: 96.7 mg/kg/day) almost corresponds to the upper limit in Guideline values (100 mg/kg/day). Besides, a 90-day diet administration test to rats reported a slight decrease in renal concentrating ability and elevated serum glucose levels at a maximal dose of 150 mg/kg bw/day, but no serious adverse effects related to the administration (USEPA/HPV (2004)). Therefore, it is judged that it corresponds to "Not classified" in an oral route. On the other hand, a dermal administration test, in which rabbits were treated with a dose of 500 mg/kg/day for 2 weeks (converted to a 90-day equivalent value: 76.7 mg/kg/day) and were treated without dosing for 2 weeks, reports only local effects but no systemic effects (USEPA/HPV (2004). The classification is not possible due to a single dose test within a range of guidance values. Besides, effects on inhalation administration are unknown due to no data. From the above, it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 48-hour LC50 = 4.13mg/L for crustacea (Daphnia magna) (HSDB, 2009), it was classified in Category 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Reliable chronic toxicity data are not obtained. It was classified in Category 2 due to lack of appropriate data on rapid degradability and acute toxicity Category 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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