NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	111-78-4
Chemical Name	Cycloocta-1,5-diene
Substance ID	m-nite-111-78-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	A flash point of 33 degrees C [closed cup] (Hommel (1996)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing neither chemical groups related to explosibility nor those related to self-reactivity.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is conceivable that it does not ignite at normal temperatures from an ignition point of 270 degrees C (Hommel (1996)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain oxygen, fluorine, or chlorine.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	On the basis of an LD50 value of 2381 mg/kg bw for rats (USEPA/HPV (2010), equivalent to List 1), it was classified as "Not classified" in JIS classification (corresponding to Category 5 in UN GHS classification).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From an LD50 value of >3520 mg/kg bw and no mortality for rats (USEPA/HPV (2010)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	An LC50 value (4 hours) is judged to be within a range of Category 4 from mortality which was 0/6, 1/6, and 4/6 at 1400, 2700, and 4300 ppm respectively in rats in 4 hours exposure (USEPA/HPV (2010)). Besides, a reference value of gasses as vapour with hardly included mist was applied because the test concentrations (1400 to 4300 ppm) are lower than 90 % of the saturated vapour pressure concentration (8947 ppm).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	"Cyclooctadiene is corrosive to the skin, with necrosis of the epidermis and ulceration and marked inflammation of the dermis" (PATTY (5th, 2001)). In addition, very severe irritation occurred, and necrosis of the epidermis and ulceration and marked inflammation of the dermis in a histopathological examination were observed in a repeated application test in which 1 mL of the test substance was applied to rabbit skins for 6 hours a day for 3 days (USEPA/HPV (2010). Therefore, it was classified in Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	From a result of a rabbit test in which irritation was shown immediately after application but the only produced conjunctivitis faded within 24 hours, the main effect was associated with the eyelids, which became red and swollen, and exuded a purulent discharge (USEPA/HPV (2010)), it was classified Category 2B.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	There is information that it is a skin sensitizer (PATTY (5th, 2001)). And a dermal sensitization test using guinea pigs reports that it is a potent skin sensitizer with 100% (10/10) positive sensitive reactions in a topical challenge test and 90% (9/10) in an intradermal challenge test (USEPA/HPV (2010)). Therefore, it was classified in Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	On the basis of a negative result in a micronucleus test (in vivo somatic cell mutagenicity test) using bone marrow cells after inhalation administration to rats (USEPA/HPV (2010)), it was classified as "Not classified." Besides, an Ames test and a chromosomal aberration test with human lymphocyte in in vitro tests reported both negative results (USEPA/HPV (2010)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	A combined repeated dose toxicity study with reproduction/development toxicity screening test by oral administration in rats (OECD TG 422: GLP) reports a decreased weight gain in parent animals as general toxicities at a high dose, no differences from a control group in parameters of mating and gestation, no adverse effects on sexual function and fertility (USEPA/HPV (2010)), and no effect on the number of litters and the number of survived offspring (USEPA/HPV (2010)). It was classified as "Classification not possible" due to insufficient data on developmental effects including teratogenicity.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	An inhalation test in which doses of 1400 to 4300 ppm (vapour) exposed to rats for 4 hours reports that all rats failed to respond to external sound stimuli by 3 hours into the exposure, ataxia and lethargy were observed, and deaths occurred at doses of 2700 ppm or higher (USEPA/HPV (2010)). Another test in which inhalation of a dose of 1500 ppm (vapour) for 6 hours a day continues for two days reports no deaths, but an action of arrest, lack of alerting response, and incordination after the first-day exposure (USEPA/HPV (2010)). On the basis of the observed symptoms, it was classified in Category 3 (narcotic effects).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory tract)	Warning	H373	P260 P314 P501	Histological effects on a nasal cavity and a kidney, such as egeneration and necrosis of nasal olfactory epithelium, increased kidney weights, and increased hyaline droplets in the kidney, were observed at a dose of 500 ppm (2.21 mg/L) (converted to a 90-day equivalent: 0.34 mg/L), which corresponds to Category 2 in guidance values, in male rats in a 2-week inhalation (vapour) exposure (USEPA/HPV (2010)). The changes in the kidney were not used as bases for classification because they are specific for male rats and are considered to be inapplicable to human, but from the effects on the nasal cavity, it was classified in Category 2 (respiratory tract) because there are general cases that increases of exposure duration or concentration lead the lesions to lungs. Besides, a NOAEL of 600 mg/kg/day (converted to a 90-day equivalent: 360 mg/kg/day) reported in a combined repeated dose toxicity study with reproduction/development toxicity screening test by oral administration in rats (OECD TG 422: GLP) (USEPA/HPV (2010)), which is above upper limit (100 mg/kg/day) of a range of guidance values, corresponds to "Not classified" in an oral route.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour EC50 = 0.87 mg/L for crustacea (Daphnia magna) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2008), it was classified in Category1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to lack of rapid degradability (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 2005)), and 72-hour NOEC＝0.93mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2008). If acute toxicity data are used for a trophic level for which chronic toxicity data are lacking, then it is classified in Category 1 due to lack of rapid degradability (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 2005)), and 48-hour EC50 = 0.87 mg/L for crustacea (Daphnia magna) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2008). It was classified in Category 1 by a comparison between the above results.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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