Item | Information |
---|---|
CAS RN | 112-25-4 |
Chemical Name | 2-Hexyloxyethanol |
Substance ID | m-nite-112-25-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
Since its flash point is 81.7degC (c.c.) (ICSC (2004), ICSC (J) (2004)), the substance was classified into Category 4 based on GHS classification criteria. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Its autoignition point is 220degC (ICSC (2004), ICSC (J) (2004)). According to classification guidelines, substances with an autoignition point of 70degC or higher are classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on its LD50 = 739, and 1480 mg/kg bw in tests using rats (SIDS (accessed in August 2008)), the substance was classified into Category 4. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
Based on its LD50 = 721, and 792 mg/kg bw in tests using rabbits (SIDS (accessed in August 2008)), the substance was classified into Category 3. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | In an inhalation exposure test using rats, since its LC50 (4h) > 0.5 mg/L (conversion > 84 ppm) (IUCLID, 2000) was less than 90% of the saturated vapour pressure concentration (129 ppm), the substance should be a "vapour with almost no included mists." However, the result provides insufficient data for classifying the substance into which of the categories from "Category 2" to "Not Classified", and thus, it was classified into "Classification not possible". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
In a test (Directive 84/449/EEC, B4) where the substance (stock solution) was applied to the skin of 6 rabbits for 4-hour, skin reactions developed within 1-hour after application (average erythema and edema Draize scores were 1.3 and 1.7, respectively). The effects were resolved between 2 to 7 days. 3 rabbits showed necrosis at the application site between Days 1 and 7, desquamation was found in 4 animals on Day 7 (SIDS (access on Aug. 2008)). The results indicated that the erythema, edema and necrosis which developed following application showed recovery or a trend of recovery within 7 days. Based on the data, the substance was classified into Category 2. In another rabbit test, there is a result of "not irritating" (SIDS (access on Aug. 2008)). In EU classification, the substance is classified into R34 (EU-Annex I (access on Aug. 2008)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
In a rabbit eye irritation test, reversible chemosis (Draize scores of 2 - 3), iritis (Draize score of 1) and corneal opacity (Draize score of 1) were observed. No injury was observed in any of the animals after 7 days (SIDS (access on Aug. 2008)). Based on the report, the substance was classified into Category 2B. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Since it showed negative results in an in vivo micronucleus test (SIDS (accessed in August 2008)), the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a rat teratogenicity test (inhalation exposure, on gestational days 6–15, doses of 20.8, 41.4, and 79.2 ppm), no abnormality such as the number of corpora lutea or loss of implantation, fetal sex ratio, malformations or variations by category (external, visceral, or skeletal) was found. The incidence of fetal atelectasis (a variation) increased in the low-dose group, but not in the intermediate- or high-dose groups (SIDS (accessed in August 2008)). In a rabbit teratogenicity test (inhalation exposure, on gestational days 6–18, doses of 20.8, 41.4, and 79.2 ppm), there was no abnormality in the numbers of pregnancies or implantations, but there were two resorptions (resorbed) in the low-dose group and one in the high-dose group. Based on the above results, since fetal atelectasis in rats and resorption in rabbits were not dose-dependent, and parental fertilities have not been tested, the substance was classified into "Classification not possible". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory organs) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
Since it has been documented that in an oral test using rats, signs of mucosal irritation were presented, indicating potential lung damage by aspiration (ECETOC, TR95, vol.2, 2005), the substance was classified into Category 2 (respiratory organ). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | After a 13-week inhalation test using rats (doses of 20, 41, and 71 ppm) (SIDS (accessed in August 2008)), in the high-dose group (conversion, 0.42 mg/L), females showed changes in liver enzymes (decreases in AST, ALT, and SDH, increase in ALP), and increases in relative kidney weight (0.76 vs 0.69 (control), p < 0.01) and relative liver weight (significant, p < 0.01). Males showed no abnormalities in liver enzymes, but increases in relative kidney weight (0.69 vs 0.64 (control), p < 0.01) and relative liver weight. These results suggested effects of inhalation exposure on the liver and the kidneys, but it is described that the significance of the changes in liver enzymes is unclear, since decreases were observed in 3/4 of the enzymes and an increase was observed in only one of the enzyme, and no histopathological lesions were found in the liver or the kidneys, and therefore, the substance was classified into "Classification not possible". As relevant information, it is described that the increase in relative kidney weight in males in the intermediate-dose group was not biologically significant, and that the increase in relative liver weight in females appears to be adaptive. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | Since its 48h-EC50 = 145 mg/L for crustaceans (Daphnia magna) (SIDS, 2004), the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Since the substance is water soluble (water solubility, 9900 mg/L (SRC, 2005)) and its preexisting classification for acute toxicity is "Not classified", it was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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