Item | Information |
---|---|
CAS RN | 115-07-1 |
Chemical Name | Propene; Propylene |
Substance ID | m-nite-115-07-1_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Category 1 |
Danger |
H220 | P210 P377 P381 P403 |
From explosion limit (2.4-10.3% (ICSC (1998))), it was classified in Category 1. Besides, it is classified in Division 2.1 (UN1077) in UNRTDG. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified |
- |
- | - | It is a flammable gas classified in Division 2.1 in UNRTDG. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Liquefied gas |
Warning |
H280 | P410+P403 | From a critical temperature (91.8 deg C (HSDB (Access on July 2013))) above + 65 deg C, it was classified as liquefied gas. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gas substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | It was classified as "Not classified" based on the information that no toxicity was observed even after 4 hours at 50,000 ppm in an inhalation test with rats (IARC 60 (1994)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it is described that it was negative in a micronucleus test with rat bone marrow cells and a gene mutation test (hprt gene mutation) with T-lymphocytes separated from rat spleen (SIDS (2008), ACGIH (7th, 2001)). And as for in vitro, it was positive only in TA1535 in the presence of metabolic activation in bacterial reverse mutation tests, but it is reported that it was negative in a mouse lymphoma test with cultured mammalian cells (SIDS (2008), ACGIH (7th, 2001), IARC (1994)), and it is described that this substance is not an in vivo mutagen based on the available evidence (SIDS (2008)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" based on the assessments of Group 3 by IARC and A4 by ACGIH. Besides, increased tumor incidence was not observed in carcinogenicity tests with mice and rats by inhalation exposure (NTP TR272 (1985)). The category was changed according to the revised GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | It is reported that in an inhalation test with rats exposed during the organogenesis period (OECD TG 412/414), no teratogenicity or fetotoxicity was observed, and no abnormalities were found in parent animals (ACGIH (7th, 2001)). However, because of no information on sexual function and fertility in males and females, the classification is not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
Narcotic effects were observed in reports of an inhalation test with rats (SIDS (2008)), an inhalation test with mice (SIDS (2008), ACGIH (7th, 2001)), an inhalation test with humans (ACGIH (7th, 2001)), and an inhalation test with cats (SIDS (2008), ACGIH (7th, 2001)), and it is described that they recovered in a relatively short time after exposure. Therefore, it was classified in Category 3 (narcotic effects). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Not classified |
- |
- | - | In four tests in which rats and mice were exposed by inhalation at 625-10,000 ppm for two weeks (converted guidance value: 96-1,538 ppm) or 14 weeks (NTP TR272 (1985)), there were no effects on general conditions and body weights in any test, and in necropsy and histopathological examinations, no effects of test substance were observed, including those in the nasal cavity. And also in cases of inhalation exposure in rats at 200-10,000 ppm (converted guidance value: 44-2,222 ppm) for 20 days (ACGIH (7th, 2001)), or mice at 200-5,000 ppm for 78 weeks (IARC 60 (1994)), no effects of test substance were shown. Furthermore, in 103-week inhalation exposure tests with rats and mice at 5,000, 10,000 ppm (NTP TR272 (1985)), as non-neoplastic lesions, there were no descriptions of effects of test substance except for changes in the nasal cavity such as squamous metaplasia, epithelial hyperplasia, and inflammation, and changes in the nasal cavity were not reported in 2-14-week exposure tests. From the above, no adverse effects of test substance were observed even at the exposure levels above the guidance values in multiple repeated inhalation exposure tests (8 tests) with rats and mice. Because this substance is gas in GHS definition, the normal exposure route is considered to be the inhalation route. Therefore, it was classified as "Not classified" from data in the inhalation route. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
From 96-hour EC50 = 33.39 mg/L by ECOSAR for algae (SIDS, 2008), it was classified in Category 3. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 3 because it is not rapidly degradable (a degradation rate by BOD: 1% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), and it was classified in Category 3 in acute toxicity. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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