NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	115-10-6
Chemical Name	dimethyl ether
Substance ID	m-nite-115-10-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Category 1	Danger	H220	P210 P377 P381 P403	Its explosion limit is 3.4–18 vol%, and its explosive range is 12% or more. (UNRTDG2.1 and ERG Guide No.115)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified	- -	-	-	Since the substance is a flammable gas, it is not oxidative.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Low pressure liquefied gas	Warning	H280	P410+P403	Since its boiling point is -24.8degC (Merck (14th, 2006), Ullmanns (6th, 2003), Howard (1997), HODOC (3rd, 1997), Lide (88th, 2008), HSDB (2008), ICSC (2002), ICSC (J) (2002)), and its critical temperature is 126.95degC (Matheson (7th, 2001)), the substance is a low-pressure liquefied gas.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gaseous substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	In an inhalation test (4h-exposure) using rats, its LC50 is 164000 ppm (DFGOT (vol. 1, 1991), PATTY (5th, 2001)), and therefore, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	There is no available in vivo data, and available in vitro data are only the negative results in a mutagenicity test (DFGOT (vol. 1, 1991), IUCLID (2000)). Therefore, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	In an inhalation exposure test using rats for 104 weeks (6 hours/day, 5 days/week), the incidence of benign and malignant mammary tumors (52.8%) in the dose group significantly increased above that in the control group (36%) but was not considered to be substance-related since mammary tumors had been present with a frequency of 53% in 436 historical rats in control groups in the laboratory (DFGOT (vol. 1, 1991); PATTY (6th, 2001); IUCLID (2000)). Since this was the only test, and due to the lack of data, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In a rat test, inhalation of 6 hours per day for 13 days before mating caused no effect on the mating behavior or on the number of pregnancies observed. From day 6 to day 16 of gestation, the pregnant rats were exposed for 6 hours per day to the same substance, and no significant changes in fetuses were found (DFGOT (vol. 1, 1991)). However, since there is no male reproductive toxicity information available, the substance was classified into "Classification not possible". The substance is also rated as D (Classification not possible to measure pregrancy risk) by the DFG (MAK/BAT, 2007).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	Since it is described that in a rabbit inhalation test (45 minutes) and in a dog inhalation test (five minutes) performed at doses above guidance values, anaesthesia, reduced blood pressure, and increased heart rate were seen (DFGOT (vol. 1, 1991)), and in humans, effects on the nervous system, such as unconsciousness, visual defects, and analgesia, were observed, the substance was classified into Category 3 (narcotic effects).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a 14-day inhalation test using rats (6 hours/day, 5 days/week), at the dose of 10000 ppm, the only significant effect was reduced body weight, and the NOAEL was determined to be < 10000 ppm. In addition, in a 13-week inhalation test using rats (6 hours/day, 5 days/week), at the dose of 20000 ppm, increased SGOT values, reduction in liver weight, and increased SGPT activity were observed, while at the dose of 2000 ppm, they were not observed. In a 13-week inhalation test using hamsters (6 hours/day, 5 days/week), at the dose of 20000 ppm, a significant reduction in the number of leukocytes was found (DFGOT (vol. 1, 1991)), but at the dose of 10000 ppm, the reduction was not significant, and the NOAEL was determined to be 5000 ppm. Since each of these doses is above the guidance value of Category 2 the substance should be equivalent to "Not classified (inhalation)." However, since there is no data on other route available, and due to the lack of data, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Based on its 96h-LC50 > 4000 mg/L for fish (guppies) and 48h-EC50 > 4000 mg/L for crustaceans (Daphnia magna) (both from IUCLID, 2000), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since it is water soluble (water solubility, 4.6E+004 mg/L (PHYSPROP Database, 2008)) and its preexisting classification for acute toxicity is "Not classified", the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information