NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	115-18-4
Chemical Name	3-Methyl-1-buten-3-ol
Substance ID	m-nite-115-18-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It corresponds to Category 2 from a flash point of 10 deg C [closed-cup] (ICSC (J) (2008)) <23 deg C and an initial boiling point of 97 deg C (ICSC (J) (2008)) >35 deg C.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	It does not contain a chemical group associated with explosive properties but contains a chemical group associated with self-reactive properties (unsaturated bond), but the classification is not possible due to no data.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 380 deg C (ICSC (J) (2008)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There is a report on two LD50 values of 1,800 mg/kg and 2,280 mg/kg for rats (SIDS (Access on June 2012)), corresponding to Category 4 and "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification), respectively. Therefore, it was classified in Category 4 by adopting a more hazardous category.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" (corresponding to Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,000 mg/kg for rabbits (SIDS (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	There is a report on an LC50 value by 4-hour exposure of >= 21.2 mg/L = 6,018 ppm for rats (OECD TG 403) (SIDS (Access on June 2012)), but because the category cannot be determined with the data alone, the classification is not possible. Besides, because the LC50 value (21.2 mg/L) was lower than 90% of the saturated vapour pressure concentration (109 mg/L), a reference value of gas was applied.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" because it was not irritating in a skin irritation test with rabbits (SIDS (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	It was classified as "Not classified" because it was not irritating in an eye irritation test with rabbits (SIDS (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that it was not sensitizing in a maximization test with guinea pigs (Directive 84/449/EEC, B.6, GLP) (IUCLID (2000)), but it is List 2 data, and the test details such as positive rate are unknown. Therefore, it was classified as "Classification not possible."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a micronucleus test by oral administration to mice (in vivo mutagenicity test) (OECD TG 474, GLP) (SIDS (Access on June 2012)). Besides, as for in vitro tests, it was reported to be negative in an Ames test (SIDS (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a one-generation reproductive test with rats orally administered before mating and during the organogenesis period (OECD TG 421 (Draft), GLP), body weights of parent animals tended to decrease or slightly decreased in the high dose group (200 mg/kg/day), but there were no differences in parameters for mating, fertility, and reproduction between treated groups and the control group. And as for the development of offspring, no abnormal findings were observed at the morphological examination of external, visceral, and skeletal system at the dose. However, because the pup viability index was reduced at the high dose, shown by an increased number of pups dying during lactation and a decreased number of pups surviving on day 5 of lactation (SIDS (Access on June 2012)), it was classified in Category 2.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	In a micronucleus test by single oral administration of 500, 1,000, and 1,500 mg/kg to mice (OECD TG 474, GLP), signs of irregular respiration, piloerection, and apathy were observed at or above 1,000 mg/kg (SIDS (Access on June 2012)), and in a 28-day repeated oral administration test with rats (OECD TG 407, GLP), there is a report on sedation, ataxia, and uncoordinated gait as toxic signs at 600 mg/kg during the first day of treatment (SIDS (Access on June 2012)). Therefore, it was classified in Category 3 (narcotic effects).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Two 28-day repeated oral administration tests with rats (OECD TG 407, GLP) are reported. In one test, apparent effects on the liver and kidney were observed at or above 200 mg/kg/day (converted guidance value: 62.2 mg/kg/day) and were hypertrophy of hepatocytes in the liver and accumulation of hyaline droplets in the kidney. Liver findings were not regarded as adverse effects because they were not accompanied by changes in related blood biochemical values, and it is described that kidney findings were alpha-2micro-Globulin accumulation specific to male rats and not applicable to humans (SIDS (Access on June 2012)). In the other test, symptoms such as apathy and salivation and changes in blood biochemical values such as decreased cholesterol were observed in some animals at 750 mg/kg/day (converted guidance value: 233 mg/kg/day), but there were no treatment-related changes in a histopathological examination, and no effects of administration were found at or below 150 mg/kg/day (IUCLID (2000)). From the above, because no adverse effects of administration were seen at doses within the guidance value range, it corresponds to "Not classified" in the oral route. However, due to no data on other routes, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	It was classified as "Not classified" because toxicity values are > 100 mg/L for all od the algae, crustacea, and fish (SIDS, 2005).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility: 1000000 mg/L, PHYSPROP Database (2009)), and it corresponds to "Not classified" in acute toxicity for algae, crustacea, and fish (SIDS, 2005).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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