Item | Information |
---|---|
CAS RN | 115-19-5 |
Chemical Name | 3-Methyl-1-butyn-3-ol |
Substance ID | m-nite-115-19-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (acetylenes) in the molecule, but the classification is not possible due to no data. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It corresponds to Category 2 from a flash point of 20 deg C [closed-cup] (Bretherick (7th, 2007)) < 23 deg C and an initial boiling point of 104-105 deg C (Merck (14th, 2006)) > 35 deg C. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (acetylenes) in the molecule, but the classification is not possible due to no data. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 350 deg C (ICSC (2009)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to hydrogen. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
It was classified in Category 4 based on an LD50 value of 1420 mg/kg for rats (SIDS (1998)). Besides, as other LD50 values, there is a report on 1950 mg/kg (IUCLID (2000)), etc., and it is described that acute oral toxicity was tested in rats with the comparable results of LD50 values within the range of 1,300-2,600 mg/kg (SIDS (1998)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,000 mg/kg for rats (OECD TG402, GLP-compliant) (SIDS (1998)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | There is a report on an LC50 value (4-hour exposure) of > 21.3 mg/L (> 6,194 ppm) for rats (OECD TG403) (SIDS (1998)), but the category cannot be determined with the data alone. Therefore, the classification is not possible. Besides, because the test concentration was lower than 90% of the saturated vapour pressure concentration, a reference value of gas was applied. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It was classified as "Not classified" on the basis that only a slight redness was observed in a test by a 20-hour occlusive application of this substance without dilution to the rabbit skin (SIDS (1998)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
It was classified in Category 1 because, in a test in which 50 microL of this substance was applied to the conjunctival sac of rabbits, staphyloma formation indicating an irreversible effect was observed after eight days, and it was judged to be a severe irritant (SIDS (1998)), and it is described that classification with R41 is necessary according to EU criteria (SIDS (1998)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | There was no indication that this substance was a sensitizer in a skin sensitization test with guinea pigs (Split Adjuvant Test) (SIDS (1998)), but because the test method is not the one approved by OECD, it was classified as "Classification not possible." | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" based on a negative result in a micronucleus test with erythrocytes after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (OECD TG474, GLP-compliant) (SIDS (1998)). Besides, as for in vitro tests, it was reported to be negative in an Ames test (SIDS (1998)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a developmental toxicity test (OECD TG 414, GLP-compliant) in which pregnant rats were orally administered during the organogenesis period, fetuses showed an increase in delayed ossification of the skull bones, thoracic vertebral bodies, and sternebrae as well as a significant increase in the number of rudimentary cervical ribs and extra ribs at the high dose (400 mg/kg) where clinical symptoms (apathy, unsteady gait, piloerection) and body weight loss appeared in maternal animals, but no malformations were observed (SIDS (1998)). The above effects in fetuses were not used for classification because these were variations or delayed ossification, and no adverse effects on the development of offspring were shown in the test. However, because there are no data on sexual function and fertility, and effects on these are unknown, it was classified as "Classification not possible." | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
A narcotic effect is described as symptoms seen in acute toxicity tests by oral or inhalation administration to rats (SIDS (1998)), and there is the knowledge that slight sedative effects on central nervous system functions were observed in a pharmacological test (SIDS (1998)). Therefore, it was classified in Category 3 (narcotic effects). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a 4-week repeated oral administration test with rats, at the high dose of 600 mg/kg/day (converted guidance value; 185 mg/kg/day), in addition to effects such as increased mortality, signs of sedation and narcosis, and reduced weight gain, as hematological changes, decreases in the number of leukocytes, hemoglobin concentration, and lymphocytes and increases in polymorphonuclear neutrophils, polychromasia, anisocytosis, and anulocytes were observed, and part of them was also seen (although slightly) at the dose of 200 mg/kg/day (converted guidance value; 62 mg/kg/day). And pathological findings were limited to the animals in the high dose group that died during the treatment, and hyperemia, focal bleeding, and erosive/ulcerative gastritis indicating irritation of the upper gastrointestinal tract were found, but histopathological changes supporting hematological changes were not seen (SIDS (1998)). Therefore, because no adverse effects were shown at the dose within the guidance value range, it can be regarded as "Not classified" in the oral route. However, there are no data and effects are unknown in the other routes. Therefore, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" because toxicity values are > 100 mg/L for all of the algae, crustacea, and fish (SIDS, 2002). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 1000000 mg/L, PHYSPROP Database, 2012), and it corresponds to "Not classified" in acute toxicity for algae, crustacea, and fish (SIDS, 2002). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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