Item | Information |
---|---|
CAS RN | 118-74-1 |
Chemical Name | Hexachlorobenzene |
Substance ID | m-nite-118-74-1_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. The classification was revised according to the GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. The classification was revised according to the GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" based on LD50 values for rats: 3,500 mg/kg (EHC 195 (1997), ACGIH (7th, 2001), DFGOT vol. 16 (2001), PATTY (6th, 2012), IARC 79 (2001), ATSDR (2002)) and 10,000 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), EHC 195 (1997), ACGIH (7th, 2001), IARC 79 (2001)). Besides, the classification was changed from Category 5 to "Not classified" according to the GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
It was classified in Category 4 based on a report on an inhalation LC50 value of 4,000 mg/m3 (4 mg/L) for mice (CEPA (1993)). Besides, because the test concentration was higher than the saturated vapour pressure concentration of 7.42*10-4 mg/L, a reference value in the unit of mg/L was applied as dust/mist. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described that it has a low skin irritation score in a test with guinea pigs (EHC 195 (1997)), it has little irritating effect on the skin in a test with unknown animal species (DFGOT vol. 16 (2001)), or it is not irritating to the skin or eye (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002)), but the details such as application time are unknown. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described that it is not irritating to the eye in a test with guinea pigs (EHC 195 (1997)), it has no effects on the eye in a test with unknown animal species (DFGOT vol. 16 (2001)), or it is not irritating to the skin or eye (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002) (2002)), but the details such as application time are unknown. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a negative result in a dominant lethal test with rats is reported (ATSDR (2002), EHC 195 (1997), ACGIH (7th, 2001), DFGOT vol. 16 (2001), PATTY (6th, 2012), IARC 79 (2001), IUCLID (2000)). And it was negative in a DNA single-strand-break test with rat hepatocytes (IARC 79 (2001)), a sister chromatid exchange test with mouse bone marrow cells (IARC 79 (2001), DFGOT vol.16 (2001)), and a DNA single-strand-break test with mice (details: not described) (DFGOT vol. 16 (2001)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test (EHC 195 (1997), IARC 79 (2001), ATSDR (2002), NTP DB (Access on July 2013), DFGOT vol. 16 (2001)) and a chromosomal aberration test with cultured mammalian cells (EHC 195 (1997), IARC 79 (2001), ATSDR (2002), DFGOT vol. 16 (2001)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
It was classified in Category 2 because it is classified in Group 2B by IARC (IARC 79 (2001)), A3 by ACGIH (ACGIH (1996)), and R by NTP (NTP (1983)), although it is classified in "Carc. Cat. 2; R45" in EU DSD classification, "Carc. 1B H350" in EU CLP classification, and B2 by EPA (IRIS (1991)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Category 1B, |
Danger |
H360 H362 |
P308+P313 P201 P202 P260 P263 P264 P270 P280 P405 P501 |
It was classified in Category 1B because it is described in the Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), ACGIH (7th, 2001), EHC 195 (1997), ATSDR (2002), DFGOT vol. 16 (2001), PATTY (6th, 2012), IARC 79 (2001) that increased mortality of offspring after birth was observed from the doses where no toxicity occurred in parent animals in an oral dose breeding test with rats or a test with rats orally dosed during gestation. Furthermore, it is described in IARC 79 (2001), EHC 195 (1997), ATSDR (2002), DFGOT vol. 16 (2001) that in epidemiological cases in Turkey, a high rate of lethality was found in newborns fed breast milk from mothers exposed to this substance, and it was judged to have lactation effects according to the GHS classification guidance for the Japanese government. From the above, it was classified in Category 1B, Additional category: Effects on or via lactation. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, skin, bone, thyroid, nervous system, kidney, endocrine system), Category 2 (immune system) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
It is described in the Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), ACGIH (7th, 2001), EHC 195 (1997), ATSDR (2002), DFGOT vol. 16 (2001), PATTY (6th, 2012), IARC 79 (2001) that in accidental exposure cases by ingestion in humans, effects on the liver, skin, bone, thyroid, or nervous system were observed, including hepatic disorder, cutaneous porphyria, arthritis, enlargement of the thyroid, and neurological symptoms (neuritis, myotonia). And it is described in IRIS (1991), ATSDR (2002), DFGOT vol.16 (2001), EHC 195 (1997) that in 3-month or 2-year oral dose (feeding) tests with rats, effects on the kidney (increased porphyrin in the kidney, renal cell adenoma, etc.) and adrenal gland (pheochromocytoma) were found at the doses (1.5-5 mg/kg/day) within the guidance value range for Category 1, and it is described in ACGIH (7th, 2001), EHC 195 (1997), ATSDR (2002), IARC 79 (2001), DFGOT vol.16 (2001) that in 3-13-week oral dose (feeding) tests with rats, mice, etc., immunosuppression was seen at the doses (15-40 mg/kg/day) within the guidance value range for Category 2. Therefore, it was classified in Category 1 (liver, skin, bone, thyroid, nervous system, kidney, endocrine system), Category 2 (immune system). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From 72-hour EC50 = 0.03 mg/L for algae (Pseudokirchneriella subcapitata) (ECETOC TR91, 2003), it was classified in Category 1. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and NOEC = 0.0023 mg/L for crustacea (Penaeus duorarum) (CEPA, 1993). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and 72-hour EC50 = 0.03 mg/L for algae (Pseudokirchneriella subcapitata) (ECETOC TR91, 2003). From the above results, it was classified in Category 1. |
FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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