Item | Information |
---|---|
CAS RN | 120-83-2 |
Chemical Name | 2,4-Dichlorophenol |
Substance ID | m-nite-120-83-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, it is written in HSDB (Access on October 2016) that it is combstible. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 500 deg C (ICSC (2010)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen and chlorine (but not fluorine) which are chemically bonded only to carbon or hydrogen. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | It is a substance with a melting point of 55 deg C or lower, but the classification is not possible due to no data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on four reported LD50 values for rats of 2,830 mg/kg (males), 3,670 mg/kg (males), 4,500 mg/kg (females) (SIDS (2008), NTP TR353 (1989)), and about 4,000 mg/kg (males and females) (SIDS (2008), EHC 93 (1989)), it was classified as "Not classified" (Category 5 in UN GHS classification). Besides, an LD50 value for rats of 580 mg/kg (EHC 93 (1989), NTP TR353 (1989)) was obtained, but it was not used for the classification because fuel oil was used as vehicle and the data is regarded as reliability 3 (not reliable) in SIDS (2008). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
Based on a report of an LD50 value of 780 mg/kg (SIDS (2008)) for rats (OECD TG 402), it was classified in Category 3. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
Based on an LC50 value (4 hours, according to OECD TG 403) for rats of 0.97 mg/L(SIDS (2008)), it was classified in Category 3. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It is reported that strong irreversible necrosis was observed after applying this substance (80% aqueous solution) to rabbit skin for 15 minutes (SIDS (2008)). In addition, many cases of deaths of workers exposed to this substance were reported (SIDS (2008), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment) Vol. 8 (2010)). It is described that contact with only 1% of the body surface may lead to death. From the above, this substance was classified in Category 1. Besides, it is classified as "Skin Corr. 1B H 314" in the EU CLP classification (ECHA C&L Inventory (Access on June 2015)). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
It is reported that severe eye damage was observed after application of this substance to the eyes of rabbits (SIDS (2008)). In addition, this substance was classified in Category 1 in the skin corrosion/irritation. From the above, it was classified in Category 1. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government, this substance was classified as "Classification not possible." As for in vivo, it was negative in a mouse spot test, negative in a micronucleus test using mouse bone marrow cells, negative in sister chromatid exchange tests using the testes and bone marrow cells of mice, positive in a DNA damage test using the stomach and colon of mice (SIDS (2008), ATSDR (1999), Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010)). As for in vitro, negative in bacterial reverse mutation tests, positive in a mouse lymphoma test, negative gene mutation tests, positive or negative in chromosome aberration tests, and positive in a sister chromatid exchange test using cultured mammalian cells were noticed (SIDS (2008), ATSDR (1999), Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010), NTP DB (Access on October 2016)). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | In carcinogenicity studies in which rats and mice were administered by feeding for 2 years, since there was no increase in test-substance-related tumor incidence in both male and female of either rats or mice, NTP concluded that there was no evidence of carcinogenicity (NTP TR353 (1989)). Though IARC described in assessment of carcinogenicity of polychlorophenols or their salts that there is evidence to suggest that this substance is not carcinogenic in experimental animals, it did not classify it (IARC 71 (1999)).Therefore, the classification is not possible for this hazard class due to no classification results by other organizations. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a 2-generation reproductive toxicity study in rats dosed by feeding, F0 and F1 parent animals showed suppressed body weight gain at 2,000 ppm or higher, staining of the hair of the lower abdomen and perigenital region, and increased relative kidney weight at 8,000 ppm, but no effect was observed on fertility. However, in F1 and F2 pups at 8,000 ppm, delayed development (lowered eye opening rate on postnatal day 14), retardation of sexual maturation (delay in preputial separation, low body weight at vaginal opening: F1 only) and increased uterus weight and reduced thymus weight at weaning were observed (Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010), SIDS (2008)). Also in a 1-generation test in which mice were dosed by drinking water, there were no effects on fertility (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010), SIDS (2008)). In addition, in a test in which pregnant rats were dosed by gavage during organogenesis period (gestation day 6-15), even at the level with maternal toxicity (4/34 rats died, suppressed body weight gain, rales), only slight developmental toxicity (delayed ossification) was seen in fetuses (Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010), SIDS (2008)). As described above, since this substance had no adverse effect on fertility in experimental animals, and its developmental effect was slight, but in the 2-generation study using rats, delays in development and sexual maturation of pups were noted at the general toxicity level of parent animals. Therefore, the substance was classified as "Classification not possible" because it could not be classified as "Not classified." |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects) |
Danger Warning |
H370 H335 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
In humans, 4 cases were reported including the case in which workers who had acute exposure to vapor or solution of this substance to the skin due to accidents, lost consciousness and died within about an hour. Based on this information, US EPA and OSHA jointly issued a warning that dermal exposure to this substance in liquid form may cause death even in a relatively small amount (about 1% of body surface area) (Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010), SIDS (2008)). In experimental animals, it was reported that in a single oral dose test in mice, all animals showed ataxia, loss of righting reflex, tremors, salivation, labored breathing, and depression, and the LD50 value was 1,276-1,352 mg/kg which is within the range of Category 2 (SIDS (2008)). Also, it was reported that in a single dose dermal toxicity test in rats, a marked decrease in motor activity and respiratory impairment were observed at 300 mg/kg equivalent to Category 1, and that they were still present up to 6 and 9 days respectively after exposure (SIDS (2008)). Based on the above, it was classified in Category 1 (central nervous system), Category 3 (narcotic effects). Furthermore, it was described that in a single inhalation exposure test in rats, there was nasal mucosa irritation in addition to eye irritation at non-lethal doses and they disappeared after 24 hours (SIDS Dossier (2008)) Therefore, it was classified as Category 3 (respiratory tract irritation). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | As for humans, it is reported that 29 cases of chloracne and 11 cases of porphyrinuria were found in a survey conducted in a factory in the USA that produced this substance and 2,4,5-trichlorophenol, and 3 cases of them had obvious porphyria cutanea tarda (PCT) (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). However, these cases are considered to be due to trichlorophenols and dioxins as impurities (BUA 31 (1988)). As for experimental animals, 13-week repeated oral dose tests using rats and mice were conducted, and the bone marrow atrophy and a decrease in erythroid and myelocytic elements were observed at 10,000 ppm (guidance value equivalent: 500 mg/kg/day) or higher, which is the dose exceeding Category 2, as main findings in rats (NTP TR353 (1989), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). Also in mice, hepatocellular necrosis at 2,500 ppm (guidance value equivalent: 375 mg/kg/day) or higher and multinucleated hepatocytes at 10,000 ppm (guidance value equivalent: 1,500 mg/kg/day) or higher, bogh of which are the dose exceeding Category 2, were seen (NTP TR353 (1989), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). In addition, in a 6-month repeated dose toxicity study using mice dosed by feeding, hypertrophy of hepatocytes, infiltration of interstitial small round cells, and thinning of adrenal cortex were observed at doses exceeding Category 2 while in a 90-day repeated dose toxicity study using mice dosed by drinking water, no effects were observed at the doses exceeding Category 2 (NTP TR353 (1989), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). In addition, two-year repeated dose toxicity studies using rats and mice dosed by feeding were conducted, in rats, effects on the respiratory organs were observed at doses exceeding Category 2, and in mice, effects on the liver was noticed at doses exceeding Category 2. However, both findings were also seen in the control group, and they were not serious effects (NTP TR353 (1989), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). As above, it is considered to correspond to "Not classified" in the oral route, but there is no data in other routes. Therefore, the substance was classified as "Classification not possible" due to lack of data. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
From 48-hour LC50 = 1.4 mg/L for crustacea (Daphnia magna) (SIDS, 2008), it was classified in Category 2. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Because it is not rapidly degradable (a degradation rate by BOD: 0 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and its 21-day NOEC (reproduction) = 0.052 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003)), it was classified in Category 1. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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