NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	121-44-8
Chemical Name	Triethylamine
Substance ID	m-nite-121-44-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	From a flash point of -6 deg C (closed cup) and a boiling point of 89.9 deg C (Merck (15th, 2013)), it was classified in Category 2. It is classified in Class 3, Subsidiary Risk 8, PG II (UN1296) in UNRTDG.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 230 deg C (ICSC(J) (2002)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Six LD50 values are reported: 182 mg/kg (DFGOT Vol.13 (1999)), 460 mg/kg (ACGIH (7th, 2015), DFGOT Vol.13 (1999), PATTY (6th, 2012)), 590 mg/kg, 560 mg/kg, 730 mg/kg (DFGOT Vol.13 (1999)) and 1,029 mg/kg (DFGOT Vol.13 (1999)). 　This substance was classified in Category 4, which has the largest number of cases, since one case corresponds to Category 3 and 5 cases correspond to Category 4.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	There are five reports of LD50 values of 415 mg/kg (DFGOT Vol.13 (1999)), 416 mg/kg (PATTY (6th, 2012)), 420 mg/kg (ACGIH (7th, 2015)), 578 mg/kg (DFGOT Vol.13 (1999)) and 580 mg/kg (SIAP (2012)) for rabbits. Based on these, this substance was classified in Category 3.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	There are three reports of LC50 (4hours) values for rats of 1,250 ppm, 2,600 ppm (DFGOT Vol.13 (1999)) and 2,633 ppm (SIDS (2012)). One corresponds to Category 3 and two correspond to Category 4. Therefore it was classified in Category 4 which has the largest number of cases. 　Besides, since the LC50 value is lower than 90% of the saturated vapor pressure concentration (75,360 ppm), a reference value in the unit of ppm was applied as vapour without mist. The classification was revised based on the newly obtained information.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In a skin irritation test using rabbits under occlusive application for 3 minutes, 1 hour or 4 hours, it was found to be corrosive (DFGOT Vol.13 (1999)). Therefore, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In an eye irritation test using rabbits with application of 0.1 mL of this substance, it was found to be corrosive (DFGOT Vol.13 (1999)). 　Therefore, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Not classified	- -	-	-	A skin sensitization test using guinea pigs was negative, and in a human patch test, no skin sensitization was observed (DFGOT Vol.13 (1999)). Therefore, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, a micronucleus test using mouse peripheral blood was equivocal in males and negative in females (NTP DB (Access on June 2016)). However, this substance was not judged as positive because reproducibility of this equivocal result was not confirmed. 　As for in vitro, a bacterial reverse mutation test and a mammalian cell sister chromatid exchange assay were negative (DFGOT Vol.13 (1999), ACGIH (7th, 2015), Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008), NTP DB (Access on June 2016)). 　From the above, this substance was classified as "Classification not possible" according to the GHS classification guidance for the Japanese Government.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	As for classifications by other organizations, ACGIH classified in A4. Therefore, this substance was classified as "Classification not possible." 　Besides, in workers exposed to numerous chemicals including this substance, increased incidence of several tumors, especially bladder tumors, were observed, but it is thought that the causative substance was not this substance but aromatic amines such as 1-naphthylamine etc. and benzidine (DFGOT Vol. 13 (1999)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, it is reported that in a three-generation study using rats administered by drinking water, no effects on reproduction and development were observed in any generation (Environmental Risk Assessment for Chemical Substances Vol. 6 (Ministry of the Environment, 2008), ACGIH (7th, 2015)). In addition, it is reported that in a test using pregnant rabbits intravenously injected, fetotoxicity occurred at doses less than those where maternal toxicity was observed (Environmental Risk Assessment for Chemical Substances Vol. 6 (Ministry of the Environment, 2008), ACGIH (7th, 2015)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	It is reported that in humans inhalation of this substance resulted in electroencephalogram changes (PATTY (6th, 2012)). 　As for experimental animals, it is reported that in a 4-hour single inhalation exposure study using rats or mice, irritation of the respiratory tract, breathing difficulties, excitation, tremors, convulsions and coordination disturbances were observed at doses within a guidance value range for Category 2 (ACGIH (7th, 2015), DFGOT Vol. 13 (1999)). Therefore, this substance was classified in Category 1 (central nervous system) and Category 3 (respiratory tract irritation). 　Besides, it is reported that in a single inhalation exposure study of this substance in human volunteers, visual disturbances (blurring of vision, decrease in visual acuity, decrease in contrast sensitivity) and associated oedema of the cornea were observed (ACGIH (7th, 2015), DFGOT Vol.13 (1999), IRIS (1991)), but it is considered that these effects were caused by corrosive nature of this substance. And also, in the previous classification it was classified in Category 1 (respiratory organs) based on the description that a decrease in breathing rate was observed at the low concentrations of 156 - 180 ppm in the inhalation exposure test using mice (ACGIH (7th, 2001)), and the description that it is corrosive. However, because no information was provided for details of exposure time, the information was not adopted for the evidence of classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory organs)	Warning	H373	P260 P314 P501	There is no relevant information about humans. 　As for experimental animals, as an example of a short term exposure at high concentrations using rats, it is reported that in an inhalation exposure study for 10 days, effects on respiratory organs (necrotic inflammation in the nasal cavity, squamous metaplasia in the trachea, perivascular edema of the lungs in death) were observed at 4,140 mg/m3 (converted guidance value: 0.46 mg/L), which is equivalent to Category 2 (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). Therefore, this substance was classified in Category 2 (respiratory organs). 　Besides, in the previous classification, the central nervous system was adopted as the target organ because effects on the central nervous system were observed in a test using rats, and visual impairment was also seen in humans. 　However, no information was provided for details of this study using rats (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)) and human visual impairment is thought to be due to irritancy. The central nervous system was not adopted as the target organ this time.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 72-hour ErC50 = 7.97 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999), Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)), it was classified in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" because it is not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 34%, 25%, 26% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), but its 72-hour NOEC (r) = 1.1 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999), Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)), and its 7-day NOEC = 7.1 mg/L for crustacea (Ceriodaphnia dubia) (SIAP, Conclusions Agreed in CoCAM 2, 2012). 　If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 34%, 25%, 26% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), and 96-hour LC50 = 24 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999), Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)). 　It was classified in Category 3 by drawing a comparison between the above results.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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