NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	122-34-9
Chemical Name	Simazine
Substance ID	m-nite-122-34-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	It is combustible (ICSC (1999)), but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on three reported LD50 values for rats of > 5,000 mg/kg (EPA RED (2006), Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)), > 7,000 mg/kg and > 10,000 mg/kg (Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)), this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	There is a report that the LD50 value for rats is > 5,000 mg/kg (Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)), which corresponds to "Not classified." 　There is a report that the LD50 value for rabbits is > 2,000 mg/kg (EPA RED (2006)), which corresponds to "Not classified." 　Based on these reports, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are two reported LC50 values (4 hours) for rats of > 1.71 mg/L (EPA RED (2006)) and > 2,100 mg/m3 (converted value: > 2.1 mg/L) (Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)), and it is presumed that these correspond to Category 4 or "Not classified." However, it was not possible to specify a category from these values.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	It is reported that this substance is slightly irritating to rabbits (PATTY (6th, 2012)). However, it is also reported that there was no irritation in a rabbit skin irritation test (ACGIH (2016), EPA RED (2006)). This substance was classified as "Not classified" since it is judged that there is no irritation corresponding to Category 2 in the GHS classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In an eye irritation test using rabbits, slight irritation (ACGIH (2016), EPA RED (2006)) or moderate irritation (PATTY (6th, 2012)) was observed. However, the US EPA assesses that the substance is not an eye irritant (EPA RED (2006)). Therefore, it is judged that the substance is a slight eye irritant, and it was classified in Category 2B.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that in skin sensitization tests using guinea pigs, all results indicated negative (ACGIH (2016), EPA RED (2006), PATTY (6th, 2012)). It is reported that also in human patch tests, no sensitization was seen (PATTY (6th, 2012)). However, this substance was classified as "Classification not possible" because details could not be confirmed on any of the above. 　The category was revised with the revision of the GHS classification guidance for the Japanese Government.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	This substance was classified as "Classification not possible," because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, a mouse dominant lethal test is negative, micronucleus tests using peripheral blood and bone marrow cells of mice are negative and a DNA damage test using mouse leukocytes is negative (IARC 73 (1999), ACGIH (7th, 2016), PATTY (6th, 2012)). As for in vitro, bacterial reverse mutation tests are negative, a gene mutation test using cultured mammalian cells is positive, chromosomal aberration tests show negative or positive results, and sister chromatid exchange tests are negative (IARC 73 (1999), ACGIH (7th, 2016), PATTY (6th, 2012), Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	There is no carcinogenicity information on humans. As for experimental animals, in carcinogenicity studies using rats and mice by the oral route (feeding), an increase in the incidence of mammary gland tumors (fibroadenoma, adenocarcinoma) was observed in female rats, but no increase in tumors was observed in both sexes of mice (IARC 73 (1999)). From the above, IARC classified this substance in Group 3 based on inadequate evidence for carcinogenicity in humans and limited evidence in experimental animals (IARC 73 (1999)). However, ACGIH focused on the mammary gland tumors in female rats and classified the substance in A3 (ACGIH (7th, 2016)). Moreover, the EU classified the substance in Carc. 2 (ECHA C&L Inventory (Access on August 2016)). Although the classification results differed depending on the evaluation organization, it was determined that more recent classification results of carcinogenicity by ACGIH and the EU than that by IARC was adopted in this classification, and this substance was classified in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a reproductive toxicity study in which rats were orally given (feeding) this substance at up to 100 ppm for three generations or up to 500 ppm for two generations, no reproductive effects were observed in any of the generations (ACGIH (7th, 2016), PATTY (6th, 2012), HSDB (Access on June 2016)). On the other hand, in developmental toxicity studies using pregnant rats administered by oral or inhalation exposure, no effects or only slight effects were observed in the fetuses (ACGIH (7th, 2016), IARC 73 (1999)). 　However, in a gavage study using pregnant rabbits (Days 7-19 of gestation), at doses at which maternal toxicity (suppression of body weight gain, tremor, lowered locomotor activity) was seen, delayed ossification, skeletal variations, reduced fetal weight, and also an increase in embryo/fetus resorptions were observed (ACGIH (7th, 2016), PATTY (6th, 2012), HSDB (Access in June 2016)). Moreover, there is a report that as the result of oral administration to female rats from postnatal days 22 to 42, delayed vaginal opening, an increase in abnormal estrous cycles, and a delay in the day of first estrus were observed (HSDB (Access on June 2016), PATTY (6th, 2012)). Also there is a report that in postnatal administration to male rats, sexual maturity (puberty) was altered in conjunction with an increase in serum testosterone level (ACGIH (7th, 2016)). 　From the above, this substance was classified in Category 2 for this hazard class because of a concern of developmental effects and effects on the sexual maturation of pups.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	It is described that in humans, by exposure to this substance, respiratory tract irritation effects, and in some cases, effects on the central nervous system including nausea, dizziness, headache, restlessness, etc. were observed (PATTY (6th, 2012), EPA RED (2006), HSDB (Access on June 2016)). Therefore, this substance was classified in Category 3 (respiratory tract irritation, narcotic effects).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system), Category 2 (nervous system)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	There is no relevant information on humans. 　As for experimental animals, it is reported that in a 104-week repeated dose toxicity study using rats dosed by feeding, hematologic effects (decreases in red blood cell count, hemoglobin concentration and hematocrit, etc.) were observed at 100 ppm (5.2 mg/kg/day), which is equivalent to Category 1. Also it is reported that in a one-year repeated dose toxicity study using dogs dosed by feeding, hematologic effects (decreases in red blood cell count, hemoglobin concentration and hematocrit, etc.) were observed at 3.6 mg/kg/day, which is equivalent to Category 1 (EPA IRIS Summary (1993), ACGIH (2016), IARC 73 (1999)). Moreover, in a 13-week repeated dose toxicity study using dogs dosed by feeding, tremors are reported at 4,000 ppm (converted guidance value: 100 mg/kg/day), which is equivalent to Category 2 (Japanese Journal of Pesticide Science Vol.15 (Pesticide Science Society of Japan, 1990)). 　Therefore, this substance was classified in Category 1 (haemal system) and Category 2 (nervous system).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 14-day EC50 = 0.14 ppm for an aquatic plant (Lemna gibba) (USDA: IPM Database, 2016), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 0.7% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1978)), and 14-day NOEL = 0.05 ppm for an aquatic plant (Lemna gibba) (USDA: IPM Database, 2016), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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