NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	122-60-1
Chemical Name	2,3-Epoxypropyl phenyl ether [Phenyl glycidyl ether]
Substance ID	m-nite-122-60-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified	- -	-	-	A flash point is 114 deg C (closed cup) (ICSC (J) (2005)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (strained ring in chemical structure) in the molecule, but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 430 deg C (GESTIS (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on reports of LD50 values of 2,600 mg/kg, 3,850 mg/kg (male), and 4,260 mg/kg (male) for rats (all in DFGOT Vol. 4 (1992)), it was classified as "Not classified" (Category 5 in UN GHS classification). The category was changed from the previous classification according to the current GHS classification guidance for the Japanese government.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	There are two reports of LD50 values of 1.5 mL/kg (1,655 mg/kg) (male) and 2,990 mg/kg for rabbits (both in DFGOT Vol.4 (1992)), one case corresponds to Category 4, and the other one corresponds to "Not classified" (Category 5 in UN GHS classification). It was classified in Category 4 by adopting the category with higher hazard.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on a description of skin irritation in humans (Environmental Risk Assessment for Chemical Substances Vol.3, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and a report that slight irritation was shown in a skin irritation test with rabbits (ACGIH (7th, 2014)), it was classified in Category 2. Besides, this substance was classified as "Skin Irrit. 2" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on a description that this substance is irritating to the eyes (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ACGIH (7th, 2014)), and a report that it was moderately irritating in an eye irritation test with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	On the basis of multiple case reports showing skin sensitization of this substance in humans (Environmental Risk Assessment for Chemical Substances Vol.3, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and that positive results were shown in multiple skin sensitization tests with guinea pigs (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), it was classified in Category 1. Besides, this substance is classified as "Skin Sens. 1" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a dominant lethal test with rats was negative, a micronucleus test with mouse bone marrow cells, and a chromosomal aberration test with rat bone marrow cells was negative, and a DNA synthesis test with mouse testes was negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ACGIH (7th, 2014), PATTY (6th, 2012), IARC 47 (1989)). As for in vitro, a bacterial reverse mutation test was positive, a gene mutation test and a chromosomal aberration test with mammalian cultured cells were negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ACGIH (7th, 2014), PATTY (6th, 2012)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	In a carcinogenicity test in which rats were exposed by inhalation to this substance for 2 years, a significant increase in the incidence of epidermoid carcinomas was observed in the anterior parts of the nasal cavity in a high dose group (12 ppm) in both female and male (IARC 47 (1989), ACGIH (7th, 2014)). Based on this result, IARC classified it in Group 2B as there was sufficient evidence of carcinogenicity in experimental animals (IARC 47 (1989), IARC 71 (1999)). Other than this, ACGIH classified it in A3 (ACGIH (7th, 2014)), EU in Carc. 1B (ECHA CL Inventory (Access on June 2017)), and Japan Society For Occupational Health (JSOH) in Group 2B (Recommendation of Occupational Exposure Limits (2016); proposal in 1991), respectively. The evidence for EU classification result was unknown, and based on the classification results by other multiple organizations, it was classified in Category 2 for this hazard class.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a test in which after male rats were exposed by inhalation to this substance for 19 days, they were mated with untreated females, and the male fertility was evaluated, seminiferous tubule degeneration was observed in 1/8 animals from each of the exposure groups at 1, 5, and 12 ppm, and a decreased male fertility index was observed in the high dose group (12 ppm) (ACGIH (7th, 2014), IARC 47 (1989), Environmental Risk Assessment for Chemical Substances Vol.3, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2004)). On the other hand, in a developmental toxicity test in which pregnant rats were exposed by inhalation to this substance (gestational day 4-15), no effect was observed in either maternal animals or fetuses at doses up to 12 ppm (ACGIH (7th, 2014), IARC 47 (1989), Environmental Risk Assessment for Chemical Substances Vol.3, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2004)). From the above, based on the decreased male fertility index in male rats, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	There are reports that in single oral dose tests with rats and mice, dyspnea and central nervous system depression occurred, and deaths were due to paralysis of the respiratory muscles (DFGOT Vol. 4 (1992), ACGIH (7th, 2014)). Although there is no detailed description of the doses at which these symptoms were observed, it is reported that the LD50 value for rats was 3,850 mg/kg exceeding the guidance value range for Category 2, and the LD50 value for mice was 1,400 mg/kg within the guidance value range for Category 2. Also, it is considered highly probable that the effects were observed at doses within or above the range for Category 2. In addition, there is a report that in single inhalation tests with rats and mice, after 4-hour inhalation at 100 ppm within the guidance value range for Category 1, there was no death, however, dyspnea, lacrimation, nasal discharge, salivation, and aerophagia were observed; and on autopsy, irritation findings were seen in the lung diagnosed as interstitial pneumonitis (DFGOT Vol. 4 (1992), ACGIH (7th, 2014)). From the above, it was classified in Category 1 (respiratory organs), Category 3 (narcotic effects). As for the information used in the previous classification, the Chemical Substance Hazard Data (CERI) is the information in List 3 in the current GHS classification guidance for the Japanese government, moreover, the information on effects on humans in the Environmental Risk Assessment for Chemical Substances Vol.3, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2004) is from the original source ICSC which is in List 3, and the details are unknown, therefore, they were not adopted. The classification result was changed from the previous classification by using the new information sources.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	No information on humans is available. As for experimental animals, in a 24-month inhalation toxicity test with rats exposed to vapour, inflammation of the respiratory mucosal epithelium and squamous metaplasia in the anterior parts of the nasal cavity were observed at 12 ppm (0.075 mg/L) within the guidance value range (vapour) for Category 1 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances Vol.3, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2004), DFGOT Vol. 4 (1992), ACGIH (7th, 2014)). From the above, it was classified in Category 1 (respiratory organs). Besides, as for a report of hepatocellular necrosis which was adopted as evidence of effects on the liver in the previous classification, it was a result from a 10-week inhalation toxicity test with rats. However, there is no description of exposure time per day, and the test data could not be confirmed in the confirmation of the original literature (Hine et al., 1956). In addition, there is a description in Initial Risk Assessment Report (NITE, CERI, NEDO, 2008) that "Terrill and Lee (1977) reported that in the test by Hine et al. (1956), although the vapour pressure of 0.01 mmHg (25 deg C) should be used as a basis for calculation of concentration, the concentration was calculated based on a vapor pressure of 0.1 mmHg (25 deg C), therefore, the value was uncertain." Since it was uncertain, it was not adopted as evidence of classification. Therefore, the classification result was different from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 96-hour LC50 = 43 mg/L for fish (Carassius auratus) (ECETOC TR91: 2003, Initial Risk Assessment (NITE, CERI, NEDO, 2008)), it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Chronic toxicity data were not obtained. Due to being rapidly degradable (readily biodegradable, average degradation rate by BOD: 51%, average degradation rate by LC: 98% (J-CHECK, 1982)), no bioaccumulation (LogKow: 1.61 (PHYSPROP Database: 2017)), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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