NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	122-99-6
Chemical Name	2-Phenoxyethanol
Substance ID	m-nite-122-99-6_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified	- -	-	-	A flash point is 127 deg C (closed cup) (HSDB (Access on July 2013)) above 93 deg C.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 500 deg C (ICSC (2003)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	There are reports on four LD50 values for rabbits of 2,000 mg/kg (PATTY (6th, 2012)), 2,251 mg/kg (SIDS (2005)), < 3,815 mg/kg (SIDS (2005)), 13 mL/kg (PATTY (6th, 2012)) and one LD50 value for rats of < 14,300 mg/kg (SIDS (2005)). Among these, one corresponds to Category 4, and four correspond to "Not classified" including "Not classified" in the Classification JIS (Category 5 in UN GHS classification). Therefore, it was classified as "Not classified" according to the GHS classification guidance for the Japanese government. The classification was conducted using the information described in PATTY (6th, 2012) obtained in this investigation.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	There are two reports that there was no effect in a test with rats by 7-hour inhalation of the saturated vapour at room temperature (SIDS (2005), PATTY (6th, 2012)). From the converted 4-hour equivalent value (176.5 mg/L) of the saturated vapour concentration, a reference value for vapour (mg/L) was applied, and it was classified as "Not classified." The classification was conducted based on data in SIDS (2005) and PATTY (6th, 2012) obtained in this investigation.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	In a skin irritation test with rabbits, transient erythema was observed in 2/6 animals for a 10% solution of this substance and 1/6 animals for a 2% solution, respectively (SIDS (2005)). And in another skin irritation test with rabbits, no irritation was found after the 24-hour occlusive application of undiluted this substance (SIDS (2005)). Furthermore, as for effects in humans, no irritation was seen in a patch test in 51 volunteers with a 10% solution of this substance, and no irritation was also observed in a patch test in 2,736 persons with a 1% solution of this substance. It was classified as "Not classified" based on the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Not classified	- -	-	-	It is reported in PATTY (6th, 2012) that two maximization tests with guinea pigs did not indicate any potential of skin sensitization. And as for effects in humans, it is reported in SIDS (2005) that there was no sensitization in a patch test in 501 patients, and there was no sensitization in a patch test in 2,736 patients. It was classified as "Not classified" based on the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, negative results in a chromosomal aberration test with rat bone marrow cells and a micronucleus test with mouse bone marrow cells are reported (SIDS (2005)). As for in vitro, it was negative in a bacterial reverse mutation test, a chromosomal aberration test and a gene mutation test (hgprt gene) with cultured mammalian cells (SIDS (2005), NTP DB (Access on June 2013)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Not classified	- -	-	-	There is no classification of carcinogenicity by the international organizations. It is reported that in 104-week drinking water administration carcinogenicity tests with rats and mice, no increased incidence of tumors or tumor-related findings was observed in either species or either sex (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (Access on June 2013)). Furthermore, FDA cancer models predict a negative result in male and female rats and male and female mice (SIDS (2005)). It was classified as "Not classified" from the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	It is described that in a two-generation breeding test with mice by oral administration, lower birth weights were observed in offspring at the dose where parent animals showed general toxicity (reduced weight gain, increased relative liver weights), and decreases in litter size and the proportion of pups born alive were found in offspring at the dose where parent animals died (males 25/32 animals, females 21/24 animals) (SIDS (2005), NTP DB (Access on June 2013)), but it was impossible to judge whether there were reproductive toxicity effects because general toxicity effects in parent animals were severe. Furthermore, it is described that in a test in which pregnant rabbits were dermally applied, no effects on fetuses were noted at the doses that produced maternal toxicity (SIDS (2005)). From the above, it was classified as "Classification not possible" due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	It is described that in an oral administration test with rats, signs of central nervous system depression such as reduction of activity, decreased reflex, labored respiration, and coma were observed (SIDS (2005)), and this substance is used as an anesthetic for fish (PATTY (6th, 2012)). Therefore, it was classified in Category 3 (narcotic effects).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a 13-week repeated oral administration test with rats, NOAEL = 80 mg/kg/day, LOAEL = 400 mg/kg/day, and inflammation in the kidney was observed at or above 400 mg/kg/day above the guidance value for Category 2 (SIDS (2005)), but NOAEL was within the guidance value range for Category 2, and toxicity effects are unclear at the upper limit of the guidance value range for Category 2. Furthermore, in a 13-week repeated dermal administration test with rabbits, there were no findings except for erythema found at the application site of the skin at 500 mg/kg/day, and there is a description of NOAEL = 500 mg/kg/day (SIDS (2005)). From the above, it corresponds to "Not classified" in the dermal route, but effects are unclear in the other routes. Therefore, it was classified as "Classification not possible" due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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