NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	122008-85-9
Chemical Name	Butyl (R)-2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propionate; Cyhalofop-butyl
Substance ID	m-nite-122008-85-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing fluorine and oxygen (but not chlorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	Not classified	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: >5,000 mg/kg (EPA Pesticide (2002), EFSA (2015), Food Sanitation Research, Vol.49, No.7 (Japan Crop Protection Association, 1999), HSDB (Access on September 2019))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: >2,000 mg/kg (EPA Pesticide (2002), EFSA (2015), HSDB (Access on September 2019)) (2) LD50 for rats: >5,000 mg/kg (EPA Pesticide (2002))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LC50 for rats (a dust, 4 hours): >5.63 mg/L (EPA Pesticide (2002), EFSA (2015), HSDB (Access on September 2019))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	[Rationale for the Classification] Based on (1), it was classified in Category 2. The classification was changed because new data were obtained. [Evidence Data] (1) In a skin sensitization test with 3 rabbits, irritation scores at 1/24/48/72 hours were all 1-2, and the reactions remained even after 7 days. Besides, mild erythema was noted in one out of 3 rabbits after 21 days (EPA Pesticide (2002)). [Reference Data, etc.] (2) This substance was non-irritant (EFSA (2015)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) This substance was non-irritant (EFSA (2015)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Not classified	- -	-	-	[Rationale for the Classification] Based on (1)-(3), it was classified as "Not classified." [Evidence Data] (1) This substance was a non-irritant and non-sensitizer (EFSA (2015)). (2) In a skin sensitization test (maximization method) with guinea pigs, it was judged to be negative (Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996)). (3) In a skin sensitization test with guinea pigs, it was judged to be negative (EPA Pesticide (2002)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), since all of the standard battery tests, including in vivo and in vitro tests, were negative, it was classified as "Not classified." [Evidence Data] (1) As for in vivo, there are reports of negative results in a mouse micronucleus test (Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996), Food Sanitation Research, Vol.49, No.7 (Japan Crop Protection Association, 1999), HSDB (Access on September 2019)), and a negative result in a chromosomal aberration test with rodent cells (EFSA (2015)). (2) As for in vitro, there are reports of negative results in a bacterial reverse mutation test and a mammalian cell chromosomal aberration test (Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996), Food Sanitation Research, Vol.49, No.7 (Japan Crop Protection Association, 1999), HSDB (Access on September 2019), EFSA (2015)) and a negative result in a gene mutation test (HSDB (Access on September 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Not classified	- -	-	-	[Rationale for the Classification] Based on classification results by other organizations in (1), it was classified as "Not classified" in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) In classification results by domestic and international organizations, it was classified as NL (Not Likely to be Carcinogenic to Humans) by EPA (EPA Annual Cancer Report (2018): classified in 2007). [Reference Data, etc.] (2) In a combined chronic toxicity/carcinogenicity study with mice dosed this substance by feeding for 18 months, no carcinogenicity was observed (Food Sanitation Research, Vol.49, No.7 (Japan Crop Protection Association, 1999)). (3) In a combined chronic toxicity/carcinogenicity study with rats dosed this substance by feeding for 24 months, no carcinogenicity was observed (Food Sanitation Research, Vol.49, No.7 (Japan Crop Protection Association, 1999)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1)-(3), it was classified as "Not classified." [Evidence Data] (1) In a two-generation reproductive toxicity study with rats dosed by feeding, no effects on pups and fertility were observed at doses where parental animals showed effects on the liver and kidney (increased liver weight and hepatocyte hypertrophy in both sexes, increased kidney weight and enlargement of renal tubular epithelium in males) (EFSA (2015), Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996)). (2) In a developmental toxicity test with rats dosed by gavage, no effects on fetuses were observed at doses where maternal toxicity (reduced body weight gain, decreased food consumption) was observed (EFSA (2015), Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996)). (3) In a developmental toxicity test with rabbits dosed by gavage, an increased incidence of skeletal variations (lumber limbs) was noted in fetuses at doses where maternal toxicity (death (no description of the number of animals), hematuria and opacity of the kidney) was observed, but this was within historical data (EFSA (2015), Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, gallbladder, kidney)	Warning	H373	P260 P314 P501	[Rationale for the Classification] Based on (1)-(4), since effects on the liver, gallbladder and kidney were noted in experimental animals at doses within the range of Category 2, it was classified in Category 2 (liver, gallbladder, kidney). The classification result was changed from the previous classification by the use of new information sources. [Evidence Data] (1) Lowered urinary pH, decreased ketones, increased liver weight in males, and increased kidney weight in females at or above 30 ppm (a converted guidance value: 4.5 mg/kg/day, within the range of Category 1), liver enlargement and darkening, hypertrophy of hepatocytes in both sexes, and increased liver weight and enlargement of the proximal renal tubules in females at or above 100 ppm (a converted guidance value: 15 mg/kg/day, within the range of Category 2), and hepatocyte necrosis in males at 300 ppm (a converted guidance value: 45 mg/kg/day, within the range of Category 2) were seen in a 3-month repeated dose toxicity study with mice by feeding (Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996)). (2) Hypertrophy of hepatocytes in males at or above 300 ppm (a converted guidance value: 15 mg/kg/day, within the range of Category 2), enlarged liver and darkening of the liver and kidney in both sexes and enlargement of hepatocytes in females at or above 1,000 ppm (a converted guidance value: 50 mg/kg/day, within the range of Category 2), and brown pigment deposition in the tubular epithelium and decreased eosinophilic bodies in the epithelium in the kidney in both sexes at 3,000 ppm (a converted guidance value: 150 mg/kg/day, above the range of Category 2) were observed in a three-month repeated dose toxicity study with rats by feeding (Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996)). (3) Gallbladder distention in females at or above 500 ppm (a converted guidance value: 12.5 mg/kg/day, within the range of Category 2), increased total bilirubin, an eosinophilic change of hepatocyte cytoplasm and hyaline droplet degeneration of the renal tubular epithelium in both sexes, increased relative liver weight and gallbladder distention in males and decreased absolute and relative thymus weights, etc. in females at a dose of 2,500 ppm (a converted guidance value: 62.5 mg/kg/day, within the range of Category 2) were observed in a repeated dose toxicity study with dogs by feeding (Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996)). (4) An eosinophilic change of hepatocyte cytoplasm and hyperplasia of the gallbladder epithelium accompanied with mucus secretion in both sexes, hypertrophy of the thyroid follicular epithelium and so on in females were abserved at 1,800 ppm (a converted guidance value: 45 mg/kg/day, within the range of Category 2) in a 12-month repeated dose toxicity study by feeding (Agricultural Chemicals Times supplement "Agricultural chemicals technology information," No.22 (Japan Crop Protection Association, 1996)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.93 mg/L for fish (Lepomis macrochirus) (U.S.EPA: OPP Pesticide Ecotoxicity Database, 2020).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (BIOWIN), and it was classified in Category 1 in acute toxicity.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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