NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	12202-17-4
Chemical Name	Lead oxide sulfate (Pb4O3(SO4))
Substance ID	m-nite-12202-17-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified	- -	-	-	It was classified as "Not classified" from the description of non-flammability (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	It was classified as "Not classified" from the description of non-flammability (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Not classified	- -	-	-	It was classified as "Not classified" from the description of non-flammability (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	The substance contains a metal (Pb), but from water solubility data of 0.01 g/L (IUCLID (2000)), it is estimated that it does not react vigorously with water.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified	- -	-	-	The substance is an inorganic compound containing oxygen, but from the information of no oxidizing properties (IUCLID (2000) information from CHEMSON Ltd. and Akros Chemicals), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,500 mg/kg for rats (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 10,000 mg/kg for rats (IUCLID, 2000).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available. Besides, as effects in humans, it is described that there are no data for the local effects of lead or inorganic lead compounds on the skin and mucous membranes (DFGMAK-Doc. 17 (2002)), and it may cause severe irritation or burns in the skin (HSDB (2010)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available. Besides, as effects in humans, it is described that there are no data for the local effects of lead or inorganic lead compounds on the mucous membranes (DFGMAK-Doc. 17 (2002)), and it may cause severe irritation or burns in the eye (HSDB (2010)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available. There are negative or positive results in chromosomal aberration tests with lymphocytes of workers exposed to lead, but it is described that most of the tests were inadequate, and the genotoxic potential of lead cannot be evaluated as a whole (DFGMAK-Doc. 17 (2002)). On the other hand, inorganic lead compounds were classified in 3A for germ cell mutagenicity in MAK/BAT (2010).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 1B because IARC classified inorganic lead compounds in Group 2A for carcinogenicity (IARC 87 (2006)). Besides, the Japan Society For Occupational Health (JSOH) classified lead compounds in 2B (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2011)), and ACGIH classified inorganic lead compounds in A3 (ACGIH (2001)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 1A	Danger	H360	P308+P313 P201 P202 P280 P405 P501	There are no data for this substance, but it is described as effects of inorganic lead compounds in humans that in the form of case series and epidemiological studies, the risk of spontaneous abortion before the 20th week of gestation is increased by maternal exposure to high concentrations, and prenatal lead exposure is associated with an increased risk of minor malformations, low birth weight, and postnatal growth rate (IARC 87 (2006)). Therefore, it was classified in Category 1A. Besides, it is reported that reduced sperm counts and sperm volume, reduced sperm motility, and morphological changes were observed after occupational exposure, but a dose-response relationship between the level of lead exposure and these effects cannot be derived from the results of most of the studies, therefore, toxicity in sperms was unknown (DFGMAK-Doc. 17 (2002)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (kidney, nervous system, gastrointestinal system, blood system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There are no data for this substance, but neurotoxic effects of lead were well recognized, both the peripheral and central nervous system are targets for lead, and it is reported that lead encephalopathy occurs in cases of acute symptomatic lead poisoning, and wrist drop and slowing of nerve conduction velocity were described in occupational exposure (IARC 87 (2006)). Therefore, it was classified in Category 1 (nervous system). Acute exposure to high concentrations of lead and lead compounds results in disturbances in proximal tubular function, and renal manifestations of acute lead poisoning are collectively presented as Fanconi syndrome (glycosuria, aminoaciduria, phosphaturia, etc.) (IARC 87 (2006)). Therefore, it was classified in Category 1 (kidney). Furthermore, it was classified in Category 1 (blood system) because it is described lead has been known to alter the blood system by inhibiting several enzymes involved in heme biosynthesis such as delta-aminolevulinic acid dehydratase, and microcytic or hypochromic anemia results from inhibition of heme synthesis and shortening of erythrocyte lifespan (ATSDR (2007)). Other than the above, it is described that colic is a consistent early symptom of occupationally exposed cases or individuals acutely exposed to high levels, accompanied by signs such as constipation, cramps, nausea, vomiting, anorexia, and weight loss (ATSDR (2007)). Therefore, it was classified in Category 1 (digestive system).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney, cardiovascular system, nervous system, blood system)	Danger	H372	P260 P264 P270 P314 P501	There are no data for this substance, but it is described that chronic exposure to high concentrations of lead and inorganic lead compounds results in irreversible changes in the kidney, including tubular atrophy, interstitial fibrosis, glomerular sclerosis, and ultimately chronic renal failure (IARC 87 (2006)). Therefore, it was classified in Category 1 (kidney). Also, it is reported that in an epidemiological survey in patients with lead poisoning, hemoglobin and hematocrit were significantly decreased compared to unexposed controls (ATSDR (2007)), and it is described that lead inhibits several enzymes involved in heme biosynthesis such as delta-aminolevulinic acid dehydratase, and microcytic or hypochromic anemia results from inhibition of heme synthesis and shortening of erythrocyte lifespan (ATSDR (2007)). Therefore, it was classified in Category 1 (blood system). On the other hand, there is a study that supported a relationship between chronic lead-poisoning and myocardial damage, in which workers with chronic lead-poisoning had electrocardiographic changed (ACGIH (2001)), and analyses of epidemiological survey data led to conclusions that lead absorption causes a significant increase in both systolic and diastolic blood pressure (ACGIH (2001)). Therefore, it was classified in Category 1 (cardiovascular system). Furthermore, it was classified in Category 1 (nervous system) because it is reported that decreased motor conduction velocities were found in workers with high blood lead concentrations (ACGIH (2001)), and Parkinsonian syndrome was observed in seven out of nine persons exposed to lead batteries for 30 years or longer (NICNAS (2007)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information