Item | Information |
---|---|
CAS RN | 123-35-3 |
Chemical Name | 7-Methyl-3-methylene-1,6-octadiene |
Substance ID | m-nite-123-35-3_v2 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 3 based on a flash point of 39 deg C (closed cup) (GESTIS (Access on April 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with self-reactive properties, an unsaturated bond, present in the molecule, but the classification is not possible due to no data. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (JECFA FAS54 (2006)) (2) LD50 for rats: > 5,000 mg/kg (It is described that there were no deaths up to the highest dose of 11,390 mg/kg) (REACH registration dossier (Access on June 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rabbits: > 5,000 mg/kg (REACH registration dossier (Access on June 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
[Rationale for the Classification] It was classified in Category 2 from (1) - (3). [Evidence Data] (1) This substance is an irritant in humans, and exposure to this substance induces dermatitis and conjunctivitis (NTP TR557 (2010)). (2) This substance is a moderate skin and eye irritant (HSDB (Access on May 2020)). (3) In an in-vitro skin irritation test using the human epidermis model (EPISKIN) according to ECVAM protocol version 1.8 (2009), it was judged as an irritant (REACH registration dossier (Access on June 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
[Rationale for the Classification] It was classified in Category 2A from (1) - (3). The classification result was changed due to new data (1) obtained. [Evidence Data] (1) In an eye irritation test with rabbits (3 animals) according to OECD TG 405, the mean score at 24/48/72 hours after application was 2 or more in 1 animal for conjunctival redness and 2 animals for chemosis, and all the reactions disappeared after 8 days (REACH registration dossier (Access on June 2020)). (2) This substance is an irritant in humans, and exposure to this substance induces dermatitis and conjunctivitis (NTP TR557 (2010)). (3) This substance is a moderate skin and eye irritant (HSDB (Access on May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] There is a description of (1), but it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) It is reported that a man employed as a brewery inspector developed a respiratory hypersensitivity reaction to this substance, a component of hops (HSDB (Access on May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). The classification result was changed due to new data obtained. [Evidence Data] (1) In a mouse local lymph node assay (LLNA) according to TG429, the SI value did not exceed 3, and it was judged as negative (REACH registration dossier (Access on June 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) As for in vivo, it is reported that it was negative in a chromosomal aberration test with bone marrow cells after single oral administration to rats (IARC 119 (2019), JECFA FAS54 (2006)) and negative in a micronucleus test with peripheral blood erythrocytes after 13-week oral administration to mice (IARC 119 (2019), NTP TR557 (2010), JECFA FAS54 (2006), HSDB (Access on May 2020), CEBS (Access on May 2020)). (2) As for in vitro, it is reported that it was negative in a bacterial reverse mutation test (IARC 119 (2019), NTP TR557 (2010), JECFA FAS54 (2006), HSDB (Access on May 2020), CEBS (Access on May 2020)) and all negative in a chromosomal aberration test and a sister chromatid exchange test with human lymphocytes, a gene mutation test and a sister chromatid exchange test with Chinese hamster V79 cells, and a sister chromatid exchange test with rat liver tumor cells (IARC 119 (2019), JECFA FAS54 (2006)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] It was classified in Category 2 from (1), (2). [Evidence Data] (1) As for classification results by domestic and international organizations, it was classified in Group 2B by IARC (IARC 119 (2019)) and Group 2B by the Japan Society for Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), proposed in 2018)). (2) In carcinogenicity tests by 2-year gavage administration of this substance to male and female rats and mice, a significant increase in the incidence of renal tubule neoplasms (adenoma or carcinoma) in male rats and significant increases in the incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma in male mice were observed. A slight increase in the incidence of renal tubule neoplasms in female rats and a slight increase in the incidence of hepatocellular neoplasms in female mice were found. From the above, it was concluded that there was clear evidence of carcinogenicity of this substance in male rats and mice, and there was equivocal evidence in female rats and mice (NTP TR557 (2010)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1) to (3), it was classified in Category 1B. After reviewing the data, since the appearance of the skeletal malformations was emphasized, and in the test in (3), reproductive and developmental effects were observed at doses at which no maternal toxicity was observed unlike the previous classification, the classification results were changed from the previous classification. [Evidence Data] (1) In a one-generation reproduction toxicity study with rats dosed by gavage, at a dose of toxicity in parent animals (increases in liver and kidney weight, etc.), an increase in the number of resorptions and a parallel decrease in the number of live fetuses, and an increase in the number of fetuses with skeletal malformations were observed (JECFA FAS54 (2006)). (2) In a developmental toxicity study with female rats dosed by gavage on days 6-15 of gestation, at a dose at which maternal toxicity (reduced body weight gain, death (one animal)) was observed, reduced numbers of visible implantation sites and live fetuses, and increased incidences of fetuses with delayed ossification and skeletal malformations were observed (JECFA FAS54 (2006)). (3) In an oral toxicity test with female rats dosed by gavage from day 15 of gestation to postnatal day 21 during the perinatal and lactation period, at a lower dose than the one at which general toxicity (a decrease in body weight, keratosis of the forestomach) was observed in dams, increases in the duration of labor and the number of stillbirths, a decrease in birth weight of offspring, an increase in the postnatal mortality (especially in week 1 of lactation), and delayed developmental indexes were observed (JECFA FAS54 (2006)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified" in the oral route and dermal route. However, classification was not possible since there was no information available for classification in the inhalation route. [Evidence Data] (1) In an acute oral toxicity test with rats dosed by gavage (dose: 670-11,390 mg/kg), no death was observed, and in general, only piloerection was observed at 1,000-11,390 mg/kg, and no abnormalities were observed in necropsy (REACH registration dossier (Access on June 2020)). (2) In an acute dermal toxicity test with rabbits (dose: 5,000 mg/kg), no deaths or systemic effects were observed, slight to moderate transient erythema and edema were observed, and no abnormalities were observed in necropsy (REACH registration dossier (Access on June 2020)). [Reference Data, etc.] (3) It was reported that ED50 for the analgesic effect in mice dosed in the oral route was 16 mg/kg, and the mice treated with this substance exhibited an increase in antinociceptive activity (analgesic effect) in a hot plate test (NTP TR557 (2010)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. There were data of (1) to (4), and all tests were carried out at doses exceeding Category 2, and in (1) and (2), effects were observed up to the minimum dose level exceeding Category 2, but since effects in the upper limit of the guidance value range were unknown, it was considered that classification was not possible. [Reference Data, etc.] (1) In a 14-week oral toxicity test with rats dosed by gavage (dose range: 250-4,000 mg/kg/day), at or above 250 mg/kg/day (converted guidance value: 194 mg/kg/day, exceeding Category 2), which was the minimum dose level, necrosis of the renal tubules in males and females, and hyaline droplet accumulation of the renal tubules in males were observed; at or above 500 mg/kg/day (converted guidance value: 389 mg/kg/day, exceeding Category 2), death, a decrease in body weight, and increased porphyrin pigmentation in the Harderian gland in males were observed; at or above 1,000 mg/kg/day (converted guidance value: 778 mg/kg/day, exceeding Category 2), increased chronic inflammation of the nose, and nephrosis in males and females, and atrophy of the mesenteric lymph node in females were observed; at 2,000 mg/kg/day (converted guidance value: 1,556 mg/kg/day, exceeding Category 2), degeneration of the olfactory epithelium, and atrophy of the spleen in males and females, atrophy of the mesenteric lymph node in males, death, and acute inflammation of the forestomach in females were observed; and at 4,000 mg/kg/day (converted guidance value: 3,111 mg/kg/day, exceeding Category 2), deaths were observed in all males and females (NTP TR557 (2010)). (2) In a 105-week oral toxicity test with rats dosed by gavage (dose range: 250-1,000 mg/kg/day), at or above 250 mg/kg/day (exceeding Category 2), which was the minimum dose level, hyperplasia of the transitional epithelium of the renal pelvis, and focal suppurative inflammation of the kidney in males and females, renal tubule nephrosis, and mineralization the renal papilla in males, and increased nephropathy in females were observed; at or above 500 mg/kg/day (exceeding Category 2), increased severity of nephropathy in males and females, chronic active inflammation of the nose, and chronic active inflammation of the forestomach in males, and renal tubule nephrosis in females were observed; and at 1,000 mg/kg/day (exceeding Category 2), deaths were observed in all males (NTP TR557 (2010)). (3) In a 14-week oral toxicity test with mice dosed by gavage (dose range: 250-4,000 mg/kg/day), at or above 500 mg/kg/day (converted guidance value: 389 mg/kg/day, exceeding Category 2), an increase in liver weight was observed in females; at 1,000 mg/kg/day (converted guidance value: 778 mg/kg/day, exceeding Category 2), a decrease in body weight in males and an increase in kidney weight in females were observed; at 2,000 mg/kg/day (converted guidance value: 1,556 mg/kg/day, exceeding Category 2), deaths (9/10 males, 8/10 females) were observed; and at 4,000 mg/kg/day (converted guidance value: 3,111 mg/kg/day, exceeding Category 2), deaths were observed in all males and females (NTP TR557 (2010)). (4) In a 105-week oral toxicity test with mice dosed by gavage (dose range: 250-1,000 mg/kg/day), at 500 mg/kg/day (exceeding Category 2), hepatocyte hypertrophy in males and females, and a decrease in body weight, bone marrow atrophy, lymphoid follicle atrophy in the spleen, and inflammation and epithelial hyperplasia in the forestomach in females were observed; and at 1,000 mg/kg/day (exceeding Category 2), a decrease in survival rate in males and females, and a decrease in body weight in males were observed (NTP TR557 (2010)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 48-hour EC50 = 0.45 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1998)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 3 because it was rapidly degradable (a 2-week degradation rate by BOD: 86% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1987)) and due to 21-day NOEC = 0.12 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1998)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to a high bioaccumulation estimate (log Kow = 4.17 (PHYSPROP, 2020)) and 96-hour LC50 = 0.92 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1998)), although it was rapidly degradable (a 2-week degradation rate by BOD: 86% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1987)). By drawing a comparison between the above results, it was classified in Category 1. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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