NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	123-38-6
Chemical Name	Propionaldehyde
Substance ID	m-nite-123-38-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Based on a flash point of -30 degrees C (closed cup) and a boiling point of 48 degrees C (HSDB (Access on June 2015)), it was classified in Category 2. It is classified in class 3, PGII in UNRTDG (UN1275).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an ignition point of 207 degrees C (HSDB (Access on June2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an organic compound that does not contain bivalent -O-O- structure in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for a liquid with a low boiling point.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	From reported LD50 values of 800-1,600 mg/kg (SIDS (2007), ACGIH (7th, 2002)), 1,410 mg/kg (SIDS (2007)), 2,000 mg/kg (males), and 1,700 mg/kg (females) (SIDS (2007), ACGIH (7th, 2002)) for rats, it was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Four LD50 values of 2,000 mg/kg (males), 2,500 mg/kg (females) (SIDS (2007), ACGIH (7th, 2002)), 5.0 mL/kg (4,036 mg/kg) (SIDS (2007)), and 5.0 mL/kg (4,036 mg/kg) (ACGIH (7th, 2002)) were reported for rabbits. It was classified as "Not classified" (Category 5 in UN GHS classification) to which most of the data (3) correspond.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	From a reported LC50 value (30 minutes) of 26,000 ppm (converted to a 4-hour equivalent: 9,200 ppm) (SIDS (2007), ACGIH (7th, 2002)) for rats, it was classified in Category 4. Besides, a reference value in the unit of ppm was applied as vapour without mist because the LC50 value is lower than 90% of the saturated vapour pressure concentration (420,000 ppm).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	In 2 skin irritation tests using rabbits (OECD TG404, GLP compliance or EPA TSCA Guideline, GLP compliance) in application of 0.5 mL undiluted this substance, in the former test, slight erythema was observed but resolved within 24 hours (BUA 195 (1996)), and in the latter test, moderate to severe irritation with necrosis was found and persisted after 14 days in 4/6 animals (SIDS (2007), ACGIH (7th, 2002)). Moreover, it is reported that in other skin irritation tests using rabbits, marked erythema was observed in 1/5 animal after application of 0.01 mL undiluted this substance (SIDS (2007), ACGIH (7th, 2002)), and it is reported that slight to severe irritation was found after 24-hour occlusive application of undiluted this substance, and PII (primary irritation index) was 3.9 (ACGIH (7th, 2002)). Furthermore, it is reported that in an irritation test using guinea pigs, severe irritation was observed, but there is no description on recovery (SIDS (2007), ACGIH (7th, 2002)). Moreover, it is reported that in a report in humans, 12 Asian volunteers were patch tested with this substance for 5 minutes, and severe erythema in 5 persons and weak erythema in 7 were found (ACGIH (7th, 2002)). From the above results, the substance was judged to be Category 2. Besides, it is classified in "Skin Irrit. 2 H315" in EU CLP classification (ECHA CL Inventory (Access on June 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It is reported that after 0.02 mL or 0.005 mL of undiluted this substance was applied into the conjunctival sac of rabbits, severe eye injury in a 0.02 mL application group and moderate irritation in a 0.005 mL application group were observed, but there is no description on recovery (SIDS (2007), ACGIH (7th, 2002)). Moreover, in another report, slight corneal injury, iritis with moderate to severe conjunctival irritation were observed after application of 0.01 mL this substance into the conjunctival sac of rabbits, but they resolved within ten days (SIDS (2007), ACGIH (7th, 2002)). From the above results, it was classified in Category 2. Besides, it is reported that corneal opacity was observed after application of one drop of undiluted this substance into the conjunctival sac of rabbits, and it did not resolve during an observation period (ACGIH (7th, 2002)), but it was not used for the classification due to unknown observation period. The substance is classified in "Eye Irrit. 2 H319" in EU CLP classification (ECHA CL Inventory (Access on June 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, it a micronucleus test in mouse bone marrow cells was negative (SIDS (2007), ACGIH (7th, 2002); Food Safety Commission of Japan, Food Additives Assessment Report (2010)). As for in vitro, a negative result of in a bacterial reverse mutation test, negative and positive results in a gene mutation test in cultured mammalian cells, positive results in a chromosomal aberration test, a sister chromatid exchange test, and an unscheduled DNA synthesis test were reported (SIDS (2007); ACGIH (7th, 2002); Food Safety Commission of Japan, Food Additives Assessment Report (2010); IRIS Summary (2008); IRIS Tox. Review (2008); NTP DB (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	There is no reproductive toxicity information in humans. As for experimental animals, in a combined repeated dose toxicity study with reproduction/developmental toxicity screening test (OECD TG 422) in rats in an inhalation route, toxic effects on fertility, and effects on survival rate and body weight on day 0 and 4 after birth in F1 offspring were not observed at the dose (maximum 1,500 ppm) where parent animals showed toxicity effects (weight gain reduction (only females), vacuolization and atrophy in the olfactory epithelium of the nasal cavity (males and females)) (IRIS Tox. Rev. (2008), ACGIH (7th, 2002), SIDS (2007)). Moreover, it is reported that in a developmental toxicity test in pregnant rats (7 animals/group) in inhalation exposure during a gestation period (day 0-20 of gestation), lower fetal weight was observed at the dose (2,500 ppm) above the dose (1,000 ppm) where maternal animals showed weight gain reduction. (IRIS Tox. Rev. (2008), ACGIH (7th, 2002), SIDS (2007)) From the above, apparent reproductive/developmental toxicity effects were not detected in the tests using experimental animals, but it is not possible to classify as "Not classified" from the result of the former test alone which is a screening test. Moreover, in the latter, only lower fetal weight is considered to be minimal effects as developmental toxicity effects at the dose where maternal toxicity occurred, and it is judged not to be adopted as evidence for the classification according to the GHS classification guidance for the Japanese government. As above, there is no finding availavle as classification evidence in the known information, but it is judged that data are not sufficient to classify it as "Not classified." Therefore, it was classified as "Classification not possible" in this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory organs), Category 3 (narcotic effects)	Warning	H371 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	This substance is irritating to the respiratory tract and has narcotic action (ACGIH (7th, 2002)). As for experimental animals, bronchitis, bronchopneumonia, and hyperemia in the liver and kidney were reported after inhalation exposure in rats (ACGIH (7th, 2002)), and the signs were observed at the dose corresponding to Category 2. There is no detailed information about hyperemia in the liver and kidney. From the above, the information to be a target for classification was the effect on respiratory organs and narcotic effects, and it was classified in Category 2 (respiratory system), Category 3 (narcotic effects).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory organs)	Warning	H373	P260 P314 P501	There is no human information. As for experimental animals, in a combined repeated dose/reproductive developmental toxicity test using rats in an inhalation route, vacuolization in the olfactory epithelial cells of the nasal cavity were observed in 52-day inhalation exposure to 150 ppm corresponding to Category 2 (converted to a Guidance value equivalent: 88.3 ppm = 0.21 mg/L (vapour)), and a recovery was found (ACGIH (7th, 2002), IRIS Tox. Review (2008), SIDS (2007)). For an oral route, in a 90-day gavage administration toxicity test using rats, weight gain reduction, necrosis, ulcer, cellular infiltration, or hemorrhage of esophagus to jejunum, decreased sperm cells, degeneration of spermatocytes in testis, lower urine pH, degeneration, necrosis, and basophilic change of tubular epithelial cells were observed at 1,000 mg/kg/day above a range of Category 2 (Food Safety Commission of Japan, Food Additives Assessment Report (2010)). Besides, in the previous classification, on the basis that a combined repeated dose/reproductive and developmental toxicity test in an inhalation route is a screening reproductive toxicity test, and toxicity effects were not observed at 90 ppm in other tests, it was classified as "Classification not possible" due to lack of data. However, this combined repeated dose/reproductive and developmental toxicity test is not a simple screening reproductive toxicity test, but a test in which detection of repeated dose toxicity was also targeted. Moreover, because the test in which toxicity was not observed used exposure conditions of 20-time exposure at 90 ppm which is converted to a value of 0.048 mg/L by exposure conditions, lower than the dose where effects occurred in the combined test, it could not be the rationale to deny the results of the combined test. As above, because vacuolization in the olfactory epithelial cells of the nasal cavity was observed at a concentration corresponding to Category 2 in an inhalation route, it was classified in Category 2 (respiratory system).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, a kinematic viscosity value is calculated to be 0.37 mm2/sec (26.7/25 degrees C) from numerical data (viscosity: 0.3167 mPa*s; density: 0.8657 g/cm3) listed in HSDB (Access on June 2015).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 96-hour LC50 = 14 mg/L for fish (Pimephales promelas) (SIDS, 2007), it was classified in Category 3.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is rapidly degradable (readily degradable: a degradation rate by 28-day BOD = 94%, a degradation rate by TOC = 97%, a degradation rate by GC = 100% (Official Bulletin of Ministry of International Trade and Industry, 1990)), classified in Category 3 for acute toxicity but estimated to be low bioaccumulative (LogPow = 0.59 (PHYSPROP Database, 2009)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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