Item | Information |
---|---|
CAS RN | 123-54-6 |
Chemical Name | Acetylacetone [2,4-pentanedione] |
Substance ID | m-nite-123-54-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of 34 degrees C (closed cup) (HSDB (Access on June 2015)), it was classified in Category 3. Besides, it is classified in class 3, subsidiary risk class 6.1, PGIII in UNRTDG (UN2310). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an ignition point of 340 degrees C (HSDB (Access on June 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
From reported LD50 values of 0.78 mL/kg (764 mg/kg) (males), 0.59 mL/kg (578 mg/kg) (females) (PATTY (6th, 2012), ACGIH (7th, 2011), SIDS (2003)), and 1,000 mg/kg (PATTY (6th, 2012)) for rats, it was classified in Category 4. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
Two LD50 values of 1,375 mg/kg (males) and 790 mg/kg (females) were reported for rabbits (ACGIH (7th, 2011), SIDS (2003)). Because one each corresponds to Category 3 and 4, it was classified in Category 3 to which the minimum LD50 value corresponds. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
From a reported LC50 value (4 hours) of 1,224 ppm for rats (PATTY (6th, 2012), ACGIH (7th, 2011), SIDS (2003)), it was classified in Category 3. Besides, a reference value in the unit of ppm was applied as vapour without mist because the LC50 value is lower than 90% of the saturated vapour pressure concentration (9,181 ppm). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It is written that in a skin irritation test using rabbits, slight erythema or slight to moderate edema was observed after 4-hour occlusive application of 0.5 mL undiluted this substance, but reversibility was shown due to only slight desquamation found after 7 days (SIDS (2003), ACGIH (7th, 2011), PATTY (6th, 2012)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
In a Draize test using rabbits, slight conjunctival redness, slight to moderate conjunctival edema and discharge, and slight iritis were observed after 1-hour application of 0.1 mL undiluted this substance, but all resolved after 24 hours (SIDS (2003)). As above, due to slight to moderate irritation observed, it was classified in Category 2B. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that 12 humans patch tested, and positive reaction in 2 and "doubtful" results in 7 were observed. However, authors mentioned that reaction in this test was due to irritation (SIDS (2003)). Furthermore, in a skin sensitization test using guinea pigs, only one animal showed weak reaction, and it was assessed to be an ambiguous result (SIDS (2003), PATTY (6th, 2012)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
As for in vivo, minimal effects were observed in a dominant lethal test in rats in inhalation exposure. However, due to high variation in values of both a control group and a group dosed with the test substance, it was not assessed to be statistically significant and not judged as positive (SIDS (2003)). A chromosomal aberration test in mouse spermatogonial cells was negative (SIDS (2003)). As for micronucleus tests using bone marrow cells after inhalation exposure or intraperitoneal administration in mice and rats, negative results were reported in all except a test in mice in intraperitoneal administration that was only positive. (SIDS (2003), ACGIH (7th, 2011), PATTY (6th, 2012)) A positive result was reported in a micronucleus test using peripheral blood after gavage administration in mice (NTP DB (Access on July 2015)). As for in vitro, a bacterial reverse mutation test and a gene mutation test in cultured mammalian cells were almost negative, but a chromosomal aberration test and a sister chromatid exchange test in cultured mammalian cells were positive. (SIDS (2003), PATTY (6th, 2012), ACGIH (7th, 2011), NTP DB (Access on July 2015)) From the above, because there exist positive results in micronucleus tests in mice in oral administration and intraperitoneal administration in vivo, and a chromosomal aberration test and a sister chromatid exchange test were positive in vitro, this substance is thought to be clastogenic, and it was classified in Category 2. Besides, the previous classification was revised. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There is no carcinogenicity information in humans. As for experimental animals, in a carcinogenicity test in rats or mice in 2-year inhalation exposure of this substance, a significant increased tumor incidence was not observed in either species of either sex at doses up to 400 ppm (Results of Carcinogenicity Tests commissioned by Ministry of Health, Labour and Welfare (Access on September 2015)). However, as noncancer lesions, inflammatory change, respiratory epithelial metaplasia, olfactory epithelial atrophy of the nasal cavity and so on were observed in both rats and mice, and in the highest dose group, weight gain reduction were found in male and female rats and male mice (Results of Carcinogenicity Tests commissioned by Ministry of Health, Labour and Welfare (Access on September 2015)), therefore, it is judged that doses were appropriately selected. Namely, it is thought that it corresponds to "Not classified" in an inhalation route, but there is no carcinogenicity information in other routes. Because there is no classification result by the international organization, the substance was classified as "Classification not possible" due to lack of data in this hazard class. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a teratogenicity test in pregnant female rats in inhalation exposure to the vapour of this substance during an organogenetic period (day 6-15 of gestation), weight gain reduction of maternal animals and lower body weight (males and females) and delayed ossification of fetuses were observed in a high-dose group (400 ppm). Lower fetal body weight was found only in males of a middle dose group (200 ppm). However, severe developmental toxicity such as deaths of fetuses and malformations was not observed at the doses up to 400 ppm where maternal toxicity was apparent (SIDS (2003), ACGIH (7th, 2011)). The above changes observed in fetuses were not included in the rationale for classification in accordance with Classification Guidance as minor changes. On the other hand, it is reported that in a dominant lethal test in which male rats were exposed to this substance in an inhalation route and mated with untreated female rats, a slight decrease in fertility of females was observed (ACGIH (7th, 2011)). However, it is written in the item of Genotoxicity in SIDS that that "significant increase in post-implantation loss" lacks reliability in statistical analysis, and the rationale for positive dominant lethality does not exist. (SIDS (2003)) Because there is no data usable for the classification from a fertility effect test other than this, the substance was classified as "Classification not possible" due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
In inhalation exposure in humans, dizziness, headache, nausea, vomiting, loss of consciousness and so on are known other than slight local irritation (SIDS (2003), PATTY (6th, 2012)). As for experimental animals, in oral administration in rats, sluggishness, unsteady gait, weakness, tremors, convulsions and so on were observed at 485-760 mg/kg (a dose range corresponding to Category 2), and the surviving animals recovered within 1-2 days (ACGIH (7th, 2011), SIDS (2003)). In inhalation exposure in rats, decreased spontaneous motility, decreased righting reflex, tremors and so on were found at 2.62-3.83 mg/L (a dose range corresponding to Category 1) (SIDS (2003)). Moreover, it is reported that animals died of central nervous system depression at 5.01 mg/L (a dose range corresponding to Category 1) in inhalation exposure in rats (ACGIH (7th, 2011)). Narcosis, coma and so on were reported in rabbits in dermal exposure at 790-1,370 mg/kg (SIDS (2003)). Furthermore, findings of narcotic effects are also written in PATTY (6th, 2012). From the above, there are tremors and convulsions to central nervous system effects, and respiratory tract irritation as other effects in experimental animals, it was classified in Category 1 (central nervous system), Category 3 (respiratory tract irritation). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | There is no human information. As for experimental animals, although a small number of administration, in a 2-week gavage administration toxicity test using rats, after 4-time administration at the dose of 500 mg/kg/day (3 animals died by 4-time administration, and 2 were sacrificed due to poor condition after 4-time administration), dyspnea, depression, tremor, ataxia, atonia of bladder, congested lung, corneal opacity, thymic necrosis, swelling/congestion of hepatocytes, nephrosis, lymphadenitis of mesenteric lymph nodes, and inflammation of the heart were observed (SIDS (2003), PATTY (6th, 2012)). In a 2-week dermal administration test using rabbits, after 4-time application at the dose of 975 mg/kg/day (application was stopped at 4 times because deaths were observed by that time, and animals were sacrificed on day 12 without further application), skin irritation (acanthosis, subcutaneous edema, dermatitis, hemorrhage, congestion, necrosis), deaths (males 1/6, females 3/6), hypoactivity, prostration, salivation, tremors, gasping, convulsions, cyanosis, hemorrhage/degeneration in the brain, and congestion hemorrhage, and a decrease/necrosis of lymphocytes of the thymus, spleen and lymph nodes were observed (SIDS (2003), PATTY (6th, 2012), ACGIH (7th, 2011)). Furthermore, also in an inhalation route, although in a range above Category 2, also in a 14-week inhalation exposure test using rats, the similar findings were observed, which were acute degeneration of cerebellar nuclei, vestibular nuclei, and corpus striata, acute lymphoid degeneration in the thymus in death cases, gliosis and malacia in the brain in the survivors, and ataxia in both cases (SIDS (2003), PATTY (6th, 2012), ACGIH (7th, 2011)). From the above, the central nervous system is considered to be a target organ, but due to a small number administration (4 days) in oral and dermal administration tests, they were not adopted for the classification in accordance with Guidance. Moreover, in an inhalation route, effects were not observed within a range of Category 2. Therefore, it was classified as "Classification not possible." |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, a kinematic viscosity value is calculated to be 0.62 mm2/sec (20 degrees C) from numerical data (viscosity: 0.6 mPa*s; density (specific gravity): 0.9721) listed in HSDB (Access on June 2015). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
From 48-hour EC50 = 34.4 mg/L for crustacea (Daphnia magna) (SIDS, 2003), it was classified in Category 3. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
If chronic toxicity data are used, then it is classified in Category 3 due to rapid degradability (readily degradable: a degradation rate by 28-day BOD = 83%, a degradation rate by GC = 100%, a degradation rate by TOC = 95% (Official Bulletin of Ministry of International Trade and Industry, 1991)), and 14-day NOEC (reproduciton rate) = 0.25 mg/L for crustacea (Daphnia magna) (SIDS, 2003). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability and a low bioaccumulation estimate (log Kow = 0.4 (PHYSPROP Database,2009)), although 96-hour LC50 = 60.1 mg/L for fish (Lepomis macrochirus) (SIDS, 2003). It was classified in Category 3 by drawing a comparison between the above results. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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