Item | Information |
---|---|
CAS RN | 123-62-6 |
Chemical Name | propionic anhydride |
Substance ID | m-nite-123-62-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
Its flash point is 66degC (Solvents Handbook, Ohmsha Ltd. (1994)), which is between 60 and 93degC. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Its autoignition point is 315degC (Ullmanns (E) (6th, 2003) vol. 30), which above 70degC. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Its rat LD50 = 2360 mg/kg (HSDB (2005)), which falls under the "Not classified" category based on the JIS classification criteria (Category 5 in the United Nations classification). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Since its rabbit LD50 = 10000 mg/kg (HSDB (2005)), the substance was classified into the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Insufficient data available. Breathing air saturated with vapor for more than 1 hr produced deaths in rats (HSDB (2005)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
This substance is reported to cause skin corrosion or burns in humans (HSDB (2005), SITTIG vol. 2). In addition, it is rated as C; R34 in the EU classification (EU-Annex 1 (accessed in November 2008)). Thus, the substance was classified into Category 1. As additional background information, propionic anhydride, in contact with water, produces propionic acid (ICSC (J) (2005)), which is skin corrosive (ICSC (J) (2005)). (Regarding propionic acid, see NITE ID926.) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
In eye irritation tests using rabbits, the substance is rated as 8 (on a scale of 1 to 10 according to the degree of injury, with 10 representing the most severe injuries) (HSDB (2005)). In addition, the substance is documented to be corrosive to human eyes (HSDB (2005)) and cause burn and irreversible damage (SITTIG vol. 2). Based on these documents, the substance was classified into Category 1. The substance is also found to be skin corrosive. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Pulmonary dysfunction similar to asthma and airway hyper-reactivity have been reported (HSDB (2005)). However, due to insufficient information available, classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 2 (lung) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
The substance is corrosive to the respiratory tract, as it is to the skin and eyes (HSDB (2005)), and impaired pulmonary functions caused by inhalation exposure to the substance is documented (HSDB (2005)). In addition, the test substance-related cases of pulmonary edemas have been frequently suggested (HSDB (2005), SITTIG vol. 2, ICSC (J) (2005)). Based on these reports, the substance was classified into Category 2 (lung). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
Since its 48-hour EC50 = 22.7 mg/L for crustaceans (Daphnia magna) (SIDS, 2007), the substance was classified into Category 3. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Its classification for acute toxicity is Category 3, it is rapidly degradable (readily biodegradable, BOD degradability: 83% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1993)), and its potential for bioaccumulation is presumably low (log Kow = 0.4 (SRC, 2005)). Based on this information, the substance was classified into the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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