NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	123-86-4
Chemical Name	Butyl acetate
Substance ID	m-nite-123-86-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of 22 deg C (closed cup) and a boiling point of 126 deg C (ICSC (2003)). Besides, it is classified in Class 3, PG II (UN1123) in UNRTDG.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 420 deg C (ICSC (2003)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Not classified	- -	-	-	Steel and aluminum can be used as a container (Hommel (1991)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on reports of LD50 values of 3,200-14,130 mg/kg (SIDS (2009)), 10,700-14,130 mg/kg (DFGOT vol. 19 (2003)), 12,760 mg/kg (male), 10,736 mg/kg (female) (SIDS (2009)), 13,100 mg/kg (male), 11,000 mg/kg (female) (CICAD 64 (2005)), and 14,130 mg/kg (CICAD 64 (2005), Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002), ACGIH (7th, 2001)) for rats, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on reports of LD50 values of > 5,000 mg/kg (ACGIH (7th, 2001)), > 5,000-17,600 mg/kg (SIDS (2009)), > 14,080 mg/kg (male, female) (SIDS (2009)), and > 20 mL/kg (=17,600 mg/kg) (DFGOT vol. 19 (2003), ACGIH (7th, 2001)) for rabbits, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	There were 4 reports of LC50 values (4 hours) of 2,000 ppm (ACGIH (7th, 2001)), > 4,000 ppm (DFGOT vol. 19 (2003)), > 32,000 mg/m3 (=6,752 ppm) (CICAD 64 (2005)) and of an LC50 value (6 hours) of > 8,000 ppm (male, female) (converted 4-hour equivalent value: 9,798 ppm) for rats (SIDS (2009)). Among these, one value corresponded to Category 3, but the category could not be identified from the other 3 values, therefore, it was classified as "Classification not possible." New information sources (SIDS (2009), CICAD 64 (2005), DFGOT vol.19 (2003)) were added, and the category was revised.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	There were 7 reports of LC50 values (4 hours) of 0.74 mg/L (OECD TG 403) (SIDS (2009)), 0.74 mg/L, 1.8 mg/L, 5.1 mg/L, > 45 mg/L (CICAD 64 (2005)), 1.86 mg/L (DFGOT vol.19 (2003), ACGIH (7th, 2001)) and > 23.4 mg/L (OECD TG 403) (SIDS (2009)) for rats. Since there was large variability even among OECD TG 403 compliant data, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	There are reports that after application of this substance (99.6%) to rabbits for 4 hours, no irritative reaction was observed and scores of eschar formation and edema were both 0 (SIDS (2009)), and that no irritation was observed in a test with guinea pigs (SIDS (2009)). In addition, there is a report that it was not irritating in a patch test by 48-hour occlusive application of 4% of this substance to volunteers (SIDS (2009)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	There is a report that after application of 0.1 mL of this substance to the eyes of rabbits, slight to moderate iritis was observed but this disappeared after 48 hours (SIDS (2009)), and there were multiple results with mild irritation or no irritation in other eye irritation tests with rabbits (SIDS (2009)). In addition, there is a report that very slight irritation was observed in volunteers exposed to this substance (70-1400 mg/m3) (SIDS (2009)). From the above results, it was classified in Category 2B.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there are reports that no sensitization was observed in a test with guinea pigs or in an ear swelling test with mice (SIDS (2009)), and there is a description no sensitization was observed in humans (Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002)), since details of the test methods and results were unknown, the data were judged to be inadequate for classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was negative in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells (SIDS (2009), ACGIH (7th, 2001), DFGOT vol. 19 (2003), NTP DB (Access on October 2014), HSDB (Access on September 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Although in a teratogenicity test with rats by the inhalation route, at doses where maternal toxicity (decreased body weight) was observed, reduced fetal growth and abnormal formation of the ribs (wavy, fused, branched) were found, and in a teratogenicity test with rabbits by the inhalation route, without maternal toxicities, increased incidences of misaligned sternebrae and retinal folds, and morphological variations of the gall bladders were observed in fetuses, these were considered not malformations but variations, and no adverse effects were observed in development including teratogenicity (SIDS (2009), CICAD 64 (2005), DFGOT vol. 19 (2003), ACGIH (2001)). In a test in which female rats were exposed by inhalation for 3 weeks before mating, then mated with untreated male animals, and subsequently exposed by inhalation until Day 16 of gestation, although maternal toxicities (decreased food consumption, decreased body weight, decreased absolute liver weight, increased relative kidney and lung weights) were observed, there were no effects on fertility, and delayed fetal growth was observed for the fetuses (CICAD 64 (2005), DFGOT vol. 19 (2003), Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002), ACGIH (2001)). Since in these studies, teratogenicity was not observed, and delayed fetal growth and variations of the fetuses were only slight effects, it was not adopted as evidence of the classification according to the GHS Classification Guidance for the Japanese Government. From the above, no effects on the developmental toxicity and fertility in female animals were observed. However, since the information on the fertility in male animals was not sufficient, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance was irritating to the respiratory tract (OEL Documentations (Japan Society For Occupational Health (JSOH), 1994), Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002), ACGIH (7th, 2001), CICAD 64 (2005), DFGOT vol. 19 (2003)). In humans, headache and nausea by inhalation exposure of the vapour, and dizziness, dyspnea, unconsciousness and weakness at high concentrations were reported (OEL Documentations (Japan Society For Occupational Health (JSOH), 1994), ACGIH (7th, 2001), CICAD 64 (2005), DFGOT vol. 19 (2003)). As for experimental animals, ataxia, forced respiration and narcotic effects by an inhalation exposure of rats at 1.3 mg/L, dyspnea as well as these symptoms by an inhalation exposure of rats at 32.6 mg/L were observed (CICAD 64 (2005), ACGIH (7th, 2001), SIDS (2009)). Symptoms such as coordination ataxia reported in an inhalation exposure of rats were considered to be due to narcotic effects of this substance. From the above, this substance was judged to have respiratory tract irritation and narcotic effects, and it was classified in Category 3 (respiratory tract irritation, narcotic effects). Besides, the following items were not adopted in the findings described in the previous classification. That is, the case of combined exposure in humans was not adopted due to the possibility of effects caused by other substances. The findings of "In an aerosol inhalation test with rats, pulmonary congestion, alveolar hemorrhage, sloughing of the bronchiolar mucosa, necrosis of the alveolar epithelial cells and pulmonary edema, etc. were observed at 540 ppm/4 hours (2.57 mg/4 hours) (ACGIH (7th, 2001))" were not adopted due to the data being on dead animals.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	As for experimental animals, in a study in which rats were exposed by inhalation to this substance (presumed to be the vapour) for 13 weeks, only effects on the respiratory organs (nasal irritation symptoms, necrosis of the olfactory epithelium) were observed at high concentrations corresponding to "Not classified" (1,500 ppm or above: 7.05 mg/L/6 hours) (SIDS (2009), CICAD 64 (2005), DFGOT vol. 19 (2003)). In addition, there is a description that also in a test in which guinea pigs were exposed by inhalation to this substance for 28 days, no effects were observed in a hematological test (blood counts), urine examinations and pathological examination (necropsy) at 4,840 mg/m3 (converted guidance value: 1.00 mg/L/6 hours) (Environmental Risk Assessment for Chemical Substances Vol.1 (Ministry of the Environment, 2002), CICAD 64 (2005)). However, there was no toxicity information through other routes and findings in humans, therefore, it was classified as "Classification not possible" due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 96-hour LC50 = 18 mg/L for fish (Pimephales promelas) (CICAD 64, 2005, SIDS, 2009).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 98% (SIDS, 2009)), and 72-hour EC10 = 296 mg/L for algae (Desmodesmus subspicatus) (CICAD 64, 2005). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 98% (SIDS, 2009)), a low bioaccumulation estimate (LogKow = 1.78 (PHYSPROP Database, 2009)) despite 96-hour LC50 = 18 mg/L for fish (Pimephales promelas) (CICAD 64, 2005, SIDS, 2009). From the above results, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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