Item | Information |
---|---|
CAS RN | 124-40-3 |
Chemical Name | Dimethylamine |
Substance ID | m-nite-124-40-3_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Category 1 |
Danger |
H220 | P210 P377 P381 P403 |
It was classified in Category 1 from explosion limit (2.8-14.4 (ICSC (2003))). Besides, it is classified in Division 2.1 (UN1032) in UNRTDG. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified |
- |
- | - | It is a flammable gas classified in Division 2.1 in UNRTDG. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Liquefied gas |
Warning |
H280 | P410+P403 | From a critical temperature (437.22 K (HSDB (Access on September 2013))) above 65 deg C, it was classified as liquefied gas (low pressure liquefied gas). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gas substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) Besides, there are reports on an LD50 value for rats of 698 mg/kg (ACGIH (7th, 2001), DFGOT vol. 7 (1996), PATTY (6th, 2012)) in a test on an aqueous solution of this substance. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
It was classified in Category 4 based on an LC50 value (4 hours) of 4,700 mL/m3 for rats (ACGIH (7th, 2001), DFGOT vol. 7 (1996)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It is described that erythema, swelling, and finally ulceration of the skin were observed in a test in which aqueous solutions of this substance were applied to the rabbit skin (DFGOT vol. 7 (1996), ACGIH (7th, 2001)) and that sharply defined hyperemia with subsequent tissue necrosis was found in a test in which a tip of the mouse tail was dipped into a solution of this substance for 2 hours (DFGOT vol. 7 (1996), ACGIH (7th, 2001)). Furthermore, it is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information. Besides, sub-categorization was not conducted because the details are unknown. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
In an eye irritation test with rabbits, the application of a 1% solution of this substance caused conjunctivitis, conjunctival edema, keratitis, and clouding of the cornea, and the application of a 5% solution of this substance caused hemorrhage in the conjunctiva, corneal edema, opacities, and vascularization, which persisted for 28 days (DFGOT vol. 7 (1996), ACGIH (7th, 2001)). And as for higher-concentration solutions of this substance (concentration: unknown), the cornea turned translucent and whitish-blue a few seconds after the application (DFGOT vol. 7 (1996), ACGIH (7th, 2001)). Furthermore, it is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H319" in EU CLP classification. It was classified in Category 1 based on the above information. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It was classified in Category 1 because it is described that it was positive (positive rate: 100%) in a maximization test with guinea pigs (occlusive application) (DFGOT vol. 7 (1996)) and that this substance was a skin sensitizer (ACGIH (7th, 2001)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a chromosomal aberration test with rat bone marrow cells (DFGOT vol. 7 (1996), IUCLID (2000)). As for in vitro, all bacterial reverse mutation tests were negative except for one weakly positive result in the bacterial strain not commonly used (ACGIH (7th, 2001), DFGOT vol. 7 (1996), NTP DB (Access on June 2013), IUCLID (2000)), and it was negative in a gene mutation test (ACGIH (7th, 2001), DFGOT vol. 7 (1996), IUCLID (2000)) and a chromosomal aberration test (DFGOT vol. 7 (1996), IUCLID (2000)) with cultured mammalian cells. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | This substance was classified as "Classification not possible" because ACGIH classified it in A4 (ACGIH (1995)). The category was changed according to the revised GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs), Category 3 (narcotic effects) |
Danger Warning |
H370 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
In an inhalation exposure test with rats, tissue damage in the mucosa of the respiratory organs was observed at exposure concentrations of 600 ppm or above (PATTY (6th, 2012)), RD50 values (concentration producing a 50% reduction in respiration rate) were determined in short-term inhalation exposure in rats and mice (DFGOT vol. 7 (1996)), and it is irritating to the respiratory tract. Therefore, it was classified in Category 1 (respiratory organs). Furthermore, it was classified in Category 3 (narcotic effects) because it is described that disturbances of motor coordination and sluggishness were found in an oral administration test with rats, mice, rabbits, and guinea pigs (ACGIH (7th, 2001)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
It was classified in Category 1 (respiratory organs) because it is described that in a 2-year inhalation exposure test with rats and mice, inflammatory, degenerative, and hyperplastic lesions in the nasal mucosa were observed in the exposure group of 50 ppm, the upper limit of the guidance value range for Category 1 (ACGIH (7th, 2001), DFGOT vol. 7 (1996), PATTY (6th, 2012)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 96-hour EC50 = 6.2 mg/L for algae (Pseudokirchneriella subcapitata) (SIAP, Conclusions Agreed in CoCAM 4, 2013). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
If chronic toxicity data are used, then it is classified in Category 3 due to rapid degradability (a degradation rate by BOD (NH3): 88% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and 50-day NOEC = 0.6 mg/L for fish (Oncorhynchus mykiss) (SIAP, Conclusions Agreed in CoCAM 4, 2013). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, there are data: 96-hour EC50 = 6.2 mg/L for algae (Pseudokirchneriella subcapitata) (SIAP, Conclusions Agreed in CoCAM 4, 2013). However, it is rapidly degradable (a degradation rate by BOD (NH3): 88% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and low bioaccumulation is estimated (log Kow = -0.38 (HSDB, 2013)). Therefore, it is classified as "Not classified." By drawing a comparison between the above results, it was classified in Category 3. |
FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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