Item | Information |
---|---|
CAS RN | 125306-83-4 |
Chemical Name | N,N-diethyl-3-(2,4,6-trimethylphenylsulfonyl)-1H-1,2,4-triazole-1-carboxamide; Cafenstrole |
Substance ID | m-nite-125306-83-4_v1 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (neighboring nitrogen atoms) present in the molecule, but the classification is not possible due to no data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There are neighboring nitrogen atoms, a chemical group associated with explosive properties, and an S=O bond, a chemical group associated with self-reactive properties, present in the molecule, but the classification is not possible due to no data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from data: it is stable to heat and decomposes at 300 deg C (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to an element (S) other than carbon or hydrogen. However, the classification is not possible due to no data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | Not classified |
- |
- | - | It was classified as "Not classified" because it is not desensitized by wetting, dilution, etc. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: >5,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), Food Sanitation Research, Vol.49 No.5 (Japan Crop Protection Association, 1999)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: >2,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1), since the category could not be identified, the classification was not possible. [Evidence Data] (1) LD50 for rats (a dust, 4 hours): >1.97 mg/L (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) In a skin irritation test with rabbits, no irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) In an eye irritation test with rabbits, transient irritation was observed, and the total scores at 1/24/48/72 hours (maximum 110) were 8.3, 2, 0, 0 (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) In skin sensitization tests (a maximization test and a Buehler test) with guinea pigs, no skin reactions were observed in both tests. Therefore, this substance was determined to be negative (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), all of the standard battery tests, including in vivo and in vitro tests, were negative. Therefore, it was classified as "Not classified." [Evidence Data] (1) As for in vivo, a negative result was reported in a mouse micronucleus test (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (2) As for in vitro, negative results were reported in bacterial reverse mutation tests and chromosomal aberration tests with cultured mammalian cells (same sources as above). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] There were no classification results by domestic and international organizations. There were no reports available for humans. Therefore, it was classified as "Not classified" based on (1) and (2). [Evidence Data] (1) In a 2-year combined chronic toxicity/carcinogenicity study with rats dosed by feeding, no increases in the incidence of tumors were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (2) In an 18-month carcinogenicity study with mice dosed by feeding, no increases in the incidence of tumors were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1), since obvious reproductive and developmental effects were observed at a dosage where parental toxicity was seen, it was classified in Category 2. [Evidence Data] (1) In a 2-generation reproductive toxicity test with rats dosed by feeding, at a dosage where parental toxicity (reduced body weight gain, decreased feed consumption, vacuolation of the jejunal villous epithelium and so on) was observed, shortening of the gestational period, decreases in the number of pups born and viable pups, decreased body weight at birth, a decrease in viability index on Day 4, and shortening of the distance from the genital tubercle to the vaginal opening and hypospadias in females, shortening of the anogenital distance in males were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Not classified |
- |
- | - | [Rationale for the Classification] There is no information on single exposure to this substance in humans. As for experimental animals, no target organ can be identified by oral, dermal or inhalation routes as described in (1)-(3). Therefore, it was classified as "Not classified." [Evidence Data] (1) In a single oral administration test with rats, there were no dead animals at 5,000 mg/kg (exceeding the range for Category 2), and no toxic symptoms were observed. Also, even in the necropsy, no specific changes in the main tissues or organs were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (2) In a single dermal administration test with rats, there were no dead animals at 2,000 mg/kg (upper limit of the range for Category 2), and no toxic symptoms were observed. Also, in the necropsy, no specific changes were observed in the main tissues or organs (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (3) In a 4-hour single inhalation exposure test with rats, only mild salivation was observed at 1.97 mg/L of the dust (corresponding to the range for Category 2; described as the highest concentration of the dust possible to generate stably), and there were no dead animals. Also, in the necropsy, no specific changes were observed in the main tissues or organs (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system, nervous system), Category 2 (liver, gastrointestinal tract) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1) to (3), in oral administration tests with experimental animals, effects on the blood system and nervous system at dosages within the range of Category 1, and effects on the liver and gastrointestinal tract at dosages within the range of Category 2 were observed. Therefore, it was classified in Category 1 (blood system, nervous system), Category 2 (liver, gastrointestinal tract). By considering new information sources, the classification result was changed from the previous classification. [Evidence Data] (1) In a 90-day repeated dose test with rats by feeding, at 800 ppm (male/female: 45.8/52.0 mg/kg/day, within the range for Category 2), an increase in lipid droplets in the jejunal villous epithelial cells, etc. were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (2) In a 90-day repeated dose test by gavage with dogs, a decrease in the acetylcholinesterase activity in the erythrocytes in males at or above 10 mg/kg/day (within the range for Category 1), decreases in hemoglobin, hematocrit values and erythrocytes counts, and increased lipid droplets in the bile duct epithelial cells in males and females, and inflammatory cell infiltration in the lungs, increased alveolar macrophages in females at or above 30 mg/kg/day (within the range of Category 2), ataxia of hindlimbs and neurofibrillary degeneration (medulla oblongata, thoracic-lumbar spinal cord, dorsal root of the lumbar spinal cord, sciatic nerve, peroneal nerve) in males and females, inflammatory cell infiltration in the lungs, increased alveolar macrophages in males, and a decrease in acetylcholinesterase activity in erythrocytes in females at or above 90 mg/kg/day (within the range for Category 2) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (3) In a one-year repeated dose test by gavage with dogs, decreases in hemoglobin, hematocrit values and erythrocytes counts at or above 10 mg/kg/day (within the range of Category 1), and increased lipid droplets in the interlobular ducts of the liver were observed at or above 30 mg/kg/day (within the range of Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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