NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	12656-85-8
Chemical Name	Lead chromate molybdate sulfate
Substance ID	m-nite-12656-85-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains metals (Mo, Pb, and Cr), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of < 0.01 mg/L (20 deg C) (HSDB (Access on August 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen). However, the classification is not possible due to no data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	Not classified	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: >5,000 mg/kg (Environ Health Canada (2008), HSDB (Access on August 2019))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) No irritation was observed in skin and eye irritation tests with rabbits in compliance with OECD TG 404 and OECD TG 405, respectively (GESTIS (Access on August 2019)). (2) No irritation was observed in a skin irritation test (no guideline followed) with rabbits (REACH registration dossier (Access on October 2019)). [Reference Data, etc.] (3) Chronic ulcers of the skin and irritative dermatitis were reported in workers who were continuously exposed to chromium-containing materials (IARC 49 (1990)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) No irritation was observed in skin and eye irritation tests with rabbits in compliance with OECD TG 404 and OECD TG 405, respectively (GESTIS (Access on August 2019)). (2) No irritation was observed in an eye irritation test (no guideline followed) with rabbits (REACH registration dossier (Access on October 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Category 1A	Danger	H334	P304+P340 P342+P311 P261 P284 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1A. [Evidence Data] (1) Chromium and chromium compounds were designated as occupational sensitizers to the airway Group 2 by the Japan Society For Occupational Health (OEL Documentations (Occupational Sensitizer classification) (Japan Society For Occupational Health (JSOH), 2010)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1A	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1A. [Evidence Data] (1) Chromium and chromium compounds were designated as occupational skin sensitizers Group 1 by the Japan Society For Occupational Health (OEL Documentations (Occupational Sensitizer classification) (Japan Society For Occupational Health (JSOH), 2010)). (2) It was described that chromium compounds were classified as skin sensitizers in the European Union Risk Assessment Report (RAR) (REACH registration dossier (Access on October 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] From (1)-(4), based on expert judgment, it was classified in Category 2. By using the new information sources, the classification result was changed from the previous classification. [Evidence Data] (1) This substance is a solid mixed phase crystal that consists of lead chromate (VI) (CAS RN 7758-97-6), lead (II) sulfate (CAS RN 7446-14-2) and lead (II) molybdate (CAS RN 10190-55-3) in proportions of 69-80%, 9-15%, and 3-7%, respectively (ECHA SVHC Support Document (2009), Environment Health Canada (2008)). (2) As for in vivo, although this substance showed a negative result in a (micronucleus) test with mouse bone marrow cells, the authors speculated that the result may not be definitive as there was no evidence that the test material was reaching the bone marrow (Environment Health Canada (2008)). (3) As for in vitro, positive and negative results in bacterial reverse mutation tests and positive results in a sister chromatid exchange test and a chromosomal aberration test with cultured mammalian cells were obtained for this substance (Environment Health Canada (2008)). (4) Lead chromate (CAS RN 7758-97-6), a major component of this substance, was classified in Category 2 in the Japanese GHS classification (GHS classification in FY2014: As for in vivo, there was a positive result in a micronucleus test with mice (IARC 49 (1990)). As for in vitro, there were positive results in a bacterial reverse mutation test, and chromosomal aberration tests and sister chromatid exchange tests with cultured human lymphocytes and/or cultured mammalian cells (NICNAS (2007), CICAD 78 (2013), IARC 49 (1990)). Based on the above findings and the fact that this substance is Cr (VI) that is poorly soluble in water, it was classified in Category 2).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on classification results by other organizations as a hexavalent chromium compound in (1), it was classified in Category 1A in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) As for classification results by domestic and international organizations, it was classified in Group 1 as chromium (VI) compounds by IARC (IARC 100 C (2012)), as K as chromium hexavalent compounds (CAS RN 18540-29-9) by NTP (NTP 14th RoC (2016)), in Group 1 as chromium (VI) compounds (CAS RN 18540-29-9) by the Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (FY2019)) and in Carc. 1B in the EU CLP (EU CLP classification (Access on August 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1A	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] There are no data on this substance. However, this substance is a mixture containing lead compounds based on (1). In addition, based on (2), it was classified in Category 1A. [Evidence Data] (1) This substance is a solid mixed phase crystal that consists of lead chromate (VI) (CAS RN 7758-97-6), lead (II) sulfate (CAS RN 7446-14-2), and lead (II) molybdate (CAS RN 10190-55-3) in proportions of 69-80%, 9-15% and 3-7%, respectively (ECHA SVHC Support Document (2009), Environment Health Canada (2008)). (2) The Japan Society For Occupational Health (JSOH) classified lead and lead compounds as reproductive toxicants Group 1 (corresponding to Category 1A) (OEL Documentations (Reproductive toxicant classification) (Japan Society For Occupational Health (JSOH), 2013)). [Reference Data, etc.] (3) It was classified in Repr. 1A in the EU CLP classification. (4) Lead chromate(VI) (CAS RN 7758-97-6) was classified in Category 1A in the Japanese GHS classification (please refer to the GHS classification in FY2014).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs, cardiovascular system, blood system, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] There are no reports on single exposure to this substance in humans or experimental animals. However, based on (1) and (2), toxicity information on lead and hexavalent chromium compounds may be helpful. Therefore, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, blood system, liver, kidney) based on (3) and (4). [Evidence Data] (1) This substance is a solid mixed phase crystal that consists of lead chromate (VI) (CAS RN 7758-97-6), lead (II) sulfate (CAS RN 7446-14-2), and lead (II) molybdate (CAS RN 10190-55-3) in proportions of 69-80%, 9-15% and 3-7%, respectively (ECHA SVHC Support Document (2009), Environment Health Canada (2008)). (2) Lead chromate (VI) of the highest content, is a lead compound and is also a hexavalent chromium compound. There is no information on lead chromate (VI) itself. However, based on information on lead compounds and hexavalent chromium compounds, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, blood system, liver, kidney) in the GHS classification in FY2014. (3) In humans, symptoms of acute lead toxicity are reported to be dullness, restlessness, irritability, poor attention span, headaches, muscular tremors, hallucinations, loss of memory and renal impairment (OEL Documentations (Occupational exposure limit based on biological monitoring) (Japan Society For Occupational Health (JSOH), 2013), ATSDR (2007), EHC 3 (1977)). (4) As acute toxic effects of hexavalent chromium compounds in humans, respiratory, cardiovascular, gastrointestinal, hematological, hepatic, renal and neurological effects are reported via the oral route (CICAD 78 (2013)). In addition, it is reported to cause respiratory tract irritation via the inhalation route (ACGIH (7th, 2001)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, respiratory organs, blood system, cardiovascular system, kidney)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1), since this substance is an inorganic lead compound consisting mainly of lead chromate, it is considered that the toxicity information on lead and hexavalent chromium compounds can be helpful. It was classified in Category 1 (central nervous system, respiratory organs, blood system, cardiovascular system, kidney) because effects on the central nervous system, blood system and kidneys were observed within the range of Category 2 by oral administration of this substance to experimental animals based on (2) and (3), effects on the nervous system, blood system, cardiovascular system and kidneys were considered as target organs for lead in humans based on (4), and it was classified in Category 1 (respiratory organs) as lead (VI) chromate based on (5). [Evidence Data] (1) This substance is a solid mixed phase crystal that consists of lead chromate (VI) (CAS RN 7758-97-6), lead (II) sulfate (CAS RN 7446-14-2), and lead (II) molybdate (CAS RN 10190-55-3) in proportions of 69-80%, 9-15%, and 3-7%, respectively (ECHA SVHC Support Document (2009), Environment Health Canada (2008)). (2) As a result of oral administration of this substance to dogs for 90 days at 2,000 ppm (60 mg/kg/day, within the range of Category 2), decreases in hemoglobin and hematocrit values, altered erythrocyte morphology, increased aminolevulinic acid in the urine, as well as pathological changes of the kidneys were observed. In addition, as clinical findings prior to death, impaired gonadal development, lethargy, anorexia, dehydration, emaciation, hyperirritability, disorientation, motor ataxia and convulsions, etc. were observed (Environment Canada/Health Canada (2008)). (3) As a result of oral administration of this substance to rats for 90 days, at 2,000 ppm (100 mg/kg/day, within the range of Category 2), similar findings as in dogs, such as hematological, urinary and renal effects, were observed (Environment Canada/Health Canada (2008)). (4) Studies on workers, and adults and children of the general population showed that the most sensitive end points for lead toxicity are the developing nervous system, the blood system (inhibition of heme synthesis, etc.), the cardiovascular system (increased blood pressure, etc.) and the kidney (depressed glomerular filtration rate, etc.) (ATSDR (2007)). (5) There is no information on lead chromate (VI), itself, but based on information on lead compounds and hexavalent chromium compounds, it was classified in Category 1 (respiratory organs) in the GHS classification in FY2014.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 4	- -	H413	P273 P501	Acute toxicity was not reported at up to a concentration of water solubility, but because it is a metal compound, and its behavior in water is unknown, it was classified in Category 4.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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