Item | Information |
---|---|
CAS RN | 1304-29-6 |
Chemical Name | Barium peroxide |
Substance ID | m-nite-1304-29-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties (neighboring oxygen atoms) present in the molecule. However, because it is classified in Division 5.1, PG II (UN1449) in UNRTDG, it does not correspond to explosives which is hazard class with the highest precedence. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC(J) (1999)) . | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There is a chemical group associated with explosive properties (neighboring oxygen atoms) present in the molecule, but it is classified in oxidizing solids. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC(J) (1999)) . | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC(J) (1999)) . | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | In contact with water, it decomposes and produces oxygen and hydrogen peroxide (ICSC(J) (1999)), but it was classified as "Not classified" because both are not combustible. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Category 2 |
Danger |
H272 | P370+P378 P210 P220 P280 P501 |
It is written that it is a strong oxidant and reacts vigorously with combustible or reducing substance (ICSC(J) (1999)). Moreover, because it is classified in Division 5.1, PG II (UN1449) in UNRTDG, it was classified in Category 2. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | This substance reacts with water to form barium hydroxide. Classification not possible due to lack of data. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Based on a description that soluble barium compounds cause irritation of the skin (HSDB (Access on June 2016)), this substance was classified in Category 2. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Based on a description that soluble barium compounds cause irritation of the eyes (HSDB (Access on June 2016)), this substance was classified in Category 2. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There is no carcinogenicity information on this substance itself. However, as described in the same hazard class on the GHS classification of barium (CAS RN 7440-39-3), the EPA classified barium and its compounds as Group D or NL (IRIS (1998)) and ACGIH classified barium and its soluble compounds as A4 (ACGIH (7th, 2001)) based on results from animal tests using barium chloride dihydrate. Therefore, this substance was also classified as "Classification not possible" based on these classifications by other organizations. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, cardiovascular system, muscular system, kidney, gastrointestinal tract), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance reacts with water to form barium hydroxide. In humans, as adverse effects of soluble barium compounds by oral intake or inhalation, gastrointestinal symptoms (nausea, vomiting, colic, and diarrhea), myocardial and general muscular stimulation, and hypokalemia have been reported along with reports on severe cases including general muscular paralysis, and death from respiratory arrest or ventricular fibrillation (ACGIH (7th, 2001)). Additionally, it is written that accidental or intentional ingestion of soluble barium compounds at high concentrations causes gastroenteritis (vomiting, diarrhoea, abdominal pain), hypokalemia, hypertension, cardiac arrhythmias, skeletal muscle paralysis, and renal failure (CICAD 33 (2001), ATSDR (2007)). It is reported that barium oxide and barium hydroxide irritate the respiratory tract (CICAD 33 (2001)). From the above, this substance was classified in Category 1 (the nervous system, cardiovascular system, muscular system, kidney, gastrointestinal tract), and Category 3 (respiratory tract irritation) because the substance was thought to have similar effects as barium hydroxide. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system, nervous system, muscular system, kidney) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There is no information on this substance itself. It is said that the toxicity of barium and barium compounds depends largely on the solubility, and toxicity is an inhibitory action of potassium channel by barium ion (ATSDR (2007)). The water solubility of this substance is 0.091g/100 g (HSDB (Access on May 2016)), thus it is difficult to dissolve in water, but decomposes on contact with water or acids (ICSC (J) (1999), HSDB (Access on May 2016)). Therefore, this substance is thought to have similar target organs as the soluble barium compounds have. It is reported that incidences of hypertension, heart disease, and stroke increased in a population of neighborhood who ingested drinking water containing water soluble barium such as barium chloride, and that an increase in mortality due to heart diseases such as vascular disorder and arteriosclerosis was observed in other similar groups (ATSDR (2007)). For the inhalation route, a high rate of elevated blood pressure was reported among workers exposed to soluble barium (mean 1.07 g/m3) through work that involved blending and grinding several grades of barium at a mineral processing facility (CICAD 33 (2001)). Among the effects of soluble barium in humans, ingestion of high levels of soluble barium compounds may cause the following acute effects: gastroenteritis (vomiting, diarrhoea, abdominal pain), hypopotassemia, hypertension, cardiac arrhythmias, and skeletal muscle paralysis (CICAD 33 (2001)). There are only several reported cases that renal failure and renal insufficiency occurred as acute barium poisoning. However, as for experimental animals, in 13-week or 2-year studies of barium dichloride or its dihydrate administered to rats or mice in drinking water, deaths attributed to nephropathy were observed at doses corresponding to Category 2 or higher (converted guidance value as barium dichloride: 271-803 mg/kg/day). It is described that the kidneys are the most sensitive target organ in the experimental animals (ATSDR (2007)). Therefore, the kidneys are thought to be one of the target organs in humans as well. From the above, effects from soluble barium compounds including this substance were thought to have a high probability of occurring in the cardiovascular system, nervous system, muscular system, and kidneys. Therefore, this substance was classified in Category 1 (cardiovascular system, nervous system, muscular system, kidney). In addition, there was a description in HSDB (Access on May 2016) that heavy exposure to the dust may produce benign pneumoconiosis. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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