Item | Information |
---|---|
CAS RN | 1306-19-0 |
Chemical Name | Cadmium oxide |
Substance ID | m-nite-1306-19-0_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Flammable solids | Not classified |
- |
- | - | Not combustible (ICSC (2005)) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Not combustible (ICSC (2005)) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Not combustible (ICSC (2005)) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | The substance is considered to be stable against water since data is available that it is insoluble in water through it contains metals (Cd) (ICSC (2005)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | Classification is not possible since no data are available though the substance is inorganic compound containing oxygen. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Not organic compound | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on a LD50 value of 72 - 296 mg/kg for rats (CaPSAR (1994)), the substance was classified into Category 3. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on a lethal dose of 0.012 mg/L (4-hour equivalence) for humans exposed cadmium oxide fumes (EHC 134 (1992)), the substance was classified into Category 1. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Since there are a number of case reports of skin irritation following exposure to high levels of cadmium oxide fumes (CaPSAR (1994)), the substance was classified into Category 2. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Since there are a number of case reports of eye irritation following exposure to high levels of cadmium oxide fumes (CaPSAR (1994)), the substance was classified into Category 2. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Because in vivo data on this substance itself available for the classification were not obtained, information on the whole cadmium compounds (as cadmium ion, Cd2+) was used for evaluation. From (1), (2), positive reports in germ cells and somatic cells were obtained on water-soluble cadmium chloride. Although water solubility of this substance is low, it may cause hazards similar to cadmium chloride when incorporated in the body, therefore, it was classified in Category 2. The category was revised by considering knowledge on the whole cadmium compounds and water solubility of this substance. [Evidence Data] (1) It is reported that after administration of cadmium (mainly cadmium chloride), chromosomal aberrations in mouse spermatocytes and hamster oocytes and altered gene expression in mouse spermatid occurred (ATSDR (2012), IARC 58 (1993)). (2) It is reported that as the result of administrating cadmium chloride to mice, dose-dependent increases in the incidences of micronuclei, sister chromatid exchanges, and chromosomal aberrations were observed in the peripheral blood. Moreover, it is reported that increased single strand breaks in the DNA were observed in rats after administrating cadmium chloride (EU-RAR (2007), DFGOT Vol. 22 (2006), NICNAS IMAP (Accessed Dec. 2018)). [Reference Data, etc.] (3) It is reported that increases in the incidences of micronuclei and sister chromatid exchanges in peripheral lymphocytes were shown in workers occupationally exposed to cadmium (compound not specified) and that human lymphocytes from people inhabiting cadmium-polluted areas of China were found to have increased micronuclei rates and a higher frequency of chromosomal aberrations and severe aberration types. However, conflicting knowledge is also reported (ATSDR (2012)). (4) As for in vivo, a dominant lethal test by administrating cadmium (mainly cadmium chloride) was negative (ATSDR (2012), IARC 58 (1993), DFGOT Vol. 22 (2006)). (5) As for in vitro, it is reported that a bacterial reverse mutation test, a chromosomal aberration test and a sister chromatid exchange test in cultured mammalian cells (CHO) were positive (NICNAS IMAP (Accessed Jan. 2019)). (6) Water solubility of this substance is 0.0096 g/L (DFGOT Vol. 22 (2006)). (7) This substance was classified in Muta. 2 in EU CLP. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Category 1A |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
Since cadmium and cadmium compounds are classified into "Group 1" in IARC (IARC 58 (1993)), "K" in NTP (NTP Roc (11th, 2004)), and into Category 1 in Japan Society For Occupational Health (JSOH), the substance was classified into Category 1A. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In an inhalation developmental toxicity test in mice, a lower pregnancy rate, increased total number of resorptions per litter and an increase in the incidence of reduced sternebral ossification were observed at doses that were parental general toxic (NTP TOX39 (1995)). Based on the data, the substance was classified into Category 2. As relevant information, lower offspring body weight was observed at dose levels that were not parental general toxic. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs, gastrointestinal system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
For humans, a case of pneumonitis was reported for a man exposed to the substance for 3 days (ACGIH (7th, 2001)). Additionally, there is a report that 9 years after a single exposure to the substance, a worker continued to show signs of progressive pulmonary fibrosis and had no improvement in respiratory function (ATSDR (2008)). In dust inhalation tests with rats, exposures to 1 - 10 mg/m3 resulted in interstitial pneumonitis, alveolar epithelial hyperplasia, alveolitis with hemorrhage, and hyperplasia of fibroblasts (ATSDR (2008)). In addition, as acute effects of cadmium compounds to humans, "chemical pneumonitis and oedema after inhalation exposure, and rapid onset with severe nausea, vomiting, and abdominal pain after ingestion" are characteristic symptoms (EHC 134 (1992)). Based on the data, the substance was classified into Category 1 (respiratory system, alimentary system). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs, kidney, bone, cardiovascular system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There are reports of "in humans, long term inhalation of cadmium oxide fumes or dusts leads to reduced lung function and emphysema" and "a substantial body of information is available indicating that the lung, kidney and bone are the main target organs upon repeated exposure to cadmium oxide/cadmium metal in occupational settings (mainly by inhalation)" (SIDS (2004)). Additionally, it was reported that hypertension and abnormalities in the electrocardiogram were observed in workers at a battery factory exposed to cadmium oxide dust (EHC 134 (1992)). Based on the data, the substance was classified into Category 1 (respiratory system, kidney, bone, cardiovascular system). As relevant information, as chronic effects of cadmium compounds to humans, "renal dysfunction such as glomerular proteinuria, hypercalciuria, disturbances in rate of calcium to phosphate, hypophosphataemia, formation of renal stones, osteomalacia and osteoporosis" are characteristic (EHC 134 (1992)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
Classified into Category 1 from its 72h-ErC50 = 79 microg/L (90 microg/L as cadmium oxide) for algae (Pseudokirchneriella subcapitata) (EU-RAR, 2003) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water is unknown from which it is a metal compound. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
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