Item | Information |
---|---|
CAS RN | 1309-60-0 |
Chemical Name | Lead dioxide |
Substance ID | m-nite-1309-60-0_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Containing no chemical groups with explosive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Not classified |
- |
- | - | Non-flammable (ICSC, 2004) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Containing no chemical groups with explosive or self-reactive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Non-combustible (ICSC, 2004) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Non-combustible (ICSC, 2004) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Stable to water (insoluble, ICSC (2004)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Category 3 |
Warning |
H272 | P370+P378 P210 P220 P280 P501 |
Inorganic compounds containing oxygen which "intensifies combustion of other materials" according to ICSC (2004). Classified into Division 5.1, Packing Group III (UN#1872) (UN Recommendations on the Transport of Dangerous Goods). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Not organic compounds | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Based on the description in HSDB (2006): "Probably a severe eye, skin, and mucous membrane irritant." The substance is thus considered severely irritating to the skin. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Based on the description in HSDB (2006): "Probably a severe eye, skin, and mucous membrane irritant." The substance is thus considered severely irritating to the eye. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in NTP DB (Access on February 2006). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
Due to the fact that the substance is classified as Category R by NTP (2005), Group 2B by IARC (1987), Category A3 by ACGIH (2001) and Category 2B by Japan Society for Occupational Health. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Category 1A |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
Based on expert judgment, given the fact that lead has been known to possess developmental neurotoxic and reproductive toxic potentials in humans. As for the health hazards, refer to "ID168, Lead, CAS: 7439-92-1," "ID48, Lead Oxide (II); Litharge, CAS: 1317-36-8," and "ID47, Lead Acetate (II), CAS: 301-04-2." |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood system, kidney, nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
Based on toxicity of inorganic lead compounds. Based on the human evidence: "The effects observed in acute and chronic studies are very similar for inorganic lead compounds. Inhalation or oral ingestion of inorganic lead has been reported to induce oral contraction and thirst, along with nausea, vomiting, upper abdominal discomfort, loss of appetite, abdominal pain and constipation suggesting gastrointestinal toxicity. The effects on hematopoietic function such as hemoglobin synthesis inhibition due to delta-aminolevulinic acid/heme synthetic enzyme inhibition and anemia caused by shortened survival of red blood cells are considered representative of toxic actions of inorganic lead. Kidney effects are evidenced by interstitial nephropathy and decreased urinary output along with proximal renal tubular damage showing Fanconi's syndrome represented by proteinuria, hematuria, urinary cast, glycosuria and aminoaciduria. Inorganic lead adversely affects the central and peripheral nervous systems, displaying in particular weakening of the muscle of the limbs, pain and spasm. There have been rare reports of adults exhibiting ataxia, headache, paresthesia, depression and coma indicative of toxic effects on the central nervous system when exposing to extremely high doses (details not shown). However, children are most sensitive to toxicity of lead, and neurodevelopmental toxicity manifested as restlessness, aggression, concentration difficulties and memory lapse has become serious problem in the U.S." (CERI Hazard Data 2001-9 (2002)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system, kidney, nervous system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Based on toxicity of inorganic lead compounds. Based on the human evidence: "The effects observed in acute and chronic studies are very similar for inorganic lead compounds. Inhalation or oral ingestion of inorganic lead has been reported to induce oral contraction and thirst, along with nausea, vomiting, upper abdominal discomfort, loss of appetite, abdominal pain and constipation suggesting gastrointestinal toxicity. The effects on hematopoietic function such as hemoglobin synthesis inhibition due to delta-aminolevulinic acid/heme synthetic enzyme inhibition and anemia caused by shortened survival of red blood cells are considered representative of toxic actions of inorganic lead. Kidney effects are evidenced by interstitial nephropathy and decreased urinary output along with proximal renal tubular damage showing Fanconi's syndrome represented by proteinuria, hematuria, urinary cast, glycosuria and aminoaciduria. Inorganic lead adversely affects the central and peripheral nervous systems, displaying in particular weakening of the muscle of the limbs, pain and spasm. There have been rare reports of adults exhibiting ataxia, headache, paresthesia, depression and coma indicative of toxic effects on the central nervous system when exposing to extremely high doses (details not shown). However, children are most sensitive to toxicity of lead, and neurodevelopmental toxicity manifested as restlessness, aggression, concentration difficulties and memory lapse has become serious problem in the U.S." (CERI Hazard Data 2001-9 (2002)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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