Item | Information |
---|---|
CAS RN | 131-11-3 |
Chemical Name | Dimethyl phthalate |
Substance ID | m-nite-131-11-3_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | From a flash point 146 deg C (closed cup) (HSDB (Access on September 2013)) above 93 deg C, it was classified as "Not classified." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 490 deg C (HSDB (Access on September 2013)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" based on LD50 values for rats of 6.8 g/kg (ACGIH (7th, 2006)), 8,200 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), PATTY (6th, 2012)), and 8,400 mg/kg (NTP TR429 (1995)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on LD50 values for rabbits of >= 10,000 mg/kg (NTP TR429 (1995)) and > 10 mL/kg (converted value: 11.9 g/kg) (ACGIH (7th, 2006), PATTY (6th, 2012)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (Category 3 in UN GHS classification) because it is described that no skin irritation was observed in a test in which this substance was repeatedly applied to rabbit skin for 90 days (ACGIH (7th, 2006), PATTY (6th, 2012)), and no skin irritation is reported in humans (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), ACGIH (7th, 2006)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
It was classified in Category 2B because no corneal injury or iridial inflammation was seen in an eye irritation/corrosion test with three rabbits (according to EEC Directive 79/831/EEC and OECD TG 405), but only slight conjunctival irritation was observed in 3/3 animals, and the animals fully recovered within 2-3 days after application (IUCLID (2000)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | In IUCLID (2000), there is a report on five patch tests in humans, all of which gave negative results, but the details are unknown. It is described that sensitization is not reported in humans (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), ACGIH (7th, 2006)), but no animal test data are available to deny sensitization. Based on the above information, it was classified as "Classification not possible" because data are lacking to classify it as "Not classified." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in dominant lethal tests with mice and rats (ACGIH (7th, 2006), IRIS (2012), IUCLID (2000)) and negative in micronucleus tests with bone marrow erythrocytes of rats and mice (NTP DB (Access on September 2013)) and chromosomal aberration tests with rats and mice (IUCLID (2000)). As for in vitro, most of the bacterial reverse mutation tests were negative (ACGIH (7th, 2006), NTP DB (Access on September 2013), NTP TR429 (1995), IUCLID (2000)), and it was positive in a mouse lymphoma test with cultured mammalian cells (ACGIH (7th, 2006), IRIS (1990), IUCLID (2000)) and negative in a chromosomal aberration test with cultured mammalian cells (ACGIH (7th, 2006), NTP DB (Access on September 2013), NTP TR429 (1995), IUCLID (2000)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it is classified in D by EPA (IRIS (1990)). The category was changed according to the GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As for developmental toxicity, it is described that in a test with rats by diet administration during gestation, no developmental toxicity was observed even at the dose where general toxicity was seen in maternal animals (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), ACGIH (7th, 2006), NTP TR429 (1995), NTP DB (Access on September 2013)), and in a diet administration test with mice, no fetal abnormalities were found at the doses that produced general toxicity in maternal animals (ACGIH (7th, 2006), NTP TR429 (1995)). However, because of no information on fertility, it was classified as "Classification not possible" due to lack of data. The information source in List 3 was deleted, and the information source in List 1 was added. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (narcotic effects, respiratory tract irritation) |
Warning |
H336 H335 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
It was judged to cause narcotic effects from the descriptions in the Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), ACGIH (7th, 2006), and NTP TR429 (1995) that ingestion causes coma in humans, and it was classified in Category 3 (narcotic effects). Furthermore, it was classified in Category 3 (respiratory tract irritation) because it is described that it is irritating to the respiratory tract in humans (ACGIH (7th, 2006)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a 33-day dermal exposure test with rabbits, no toxicity effects were observed even after application of the dose (converted guidance value: 1,750 mg/kg/day) above the range for Category 2 (ACGIH (7th, 2006)). Therefore, it falls under "Not classified" in the dermal route. However, because of no toxicity information on the other routes, the classification is not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 96-hour LC50 = 29 mg/L for fish (Cyprinodon variegatus) (Environmental Risk Assessment for Chemical Substances Vol. 1 (Ministry of the Environment, 2002); ECETOC TR91, 2003). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 93% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1989)), and 21-day NOEC = 9.6 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 1 (Ministry of the Environment, 2002); ECETOC TR91, 2003). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, there are data: 96-hour EC50 = 54 mg/L for algae (Gymnodinium breve) (Environmental Risk Assessment for Chemical Substances Vol. 1 (Ministry of the Environment, 2002)). However, it is rapidly degradable (a degradation rate by BOD: 93% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1989)), and low bioaccumulation is estimated (log Kow = 1.60 (HSDB, 2013)). Therefore, it is classified as "Not classified." From the above results, it was classified as "Not classified." |
FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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