NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1310-66-3
Chemical Name	Lithium hydroxide monohydrate
Substance ID	m-nite-1310-66-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2009)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2009)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2009)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because data of water solubility: 19.1 g/100 mL (ICSC (2009)) were obtained, it is estimated that it does not react vigorously with water or emit flammable gases.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available. Besides, there is information that because the substance is corrosive to aluminum and zinc, they are unsuitable as a container (Hommel (1991)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a report of an LD50 value of 210 mg/kg for rats (GESTIS (Access on September 2014)). However, it is an information source in List 3 and it is not possible to confirm the original source, therefore, it was classified as "Classification not possible." The information source was changed, and the category was revised.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on a report of an LC50 value of 0.96 mg/L for rats (GESTIS (Access on September 2014); original reference: Rebar, A. H., et al. (1986)), it was classified in Category 3. Besides, based on a description that the test was conducted with an aerosol of lithium hydroxide hydrate generated by the combustion of metal lithium in highly humid conditions, the reference value of the dust/mist was applied.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Since there is a description that dermal contact with lithium hydride (CAS RN 7580-67-8) may cause a severe chemical burn (ACGIH (7th, 2001)), it was classified in Category 1. Besides, this substance is classified as "C: R35" in EU DSD classification, and as "Skin Corr. 1A H314" in EU CLP classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There are no concrete data. However, there is a description that lithium hydride (CAS RN 7580-67-8) is irritating to the eyes at low concentrations, and causes permanent eye injury at high concentrations (ACGIH (7th, 2001)). In addition, this substance was classified in Category 1 for Skin corrosion/irritation classification. From the above results, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Category 2,	Warning	H361 H362	P308+P313 P201 P202 P260 P263 P264 P270 P280 P405 P501	Although there is no data for this substance, teratogenicity of lithium by oral ingestion at medical doses for human has been studied. It is well known that lithium can pass through the human placenta. In a survey that ended in 1979, it was reported that 25 instances of congenital malformation occurred among 226 pregnant women who received lithium carbonate for therapy. Ebstein's anomaly (congenital cardiovascular malformation) had been said to be associated with lithium therapy. However, this association was thought to be weak, and pharmacological doses of lithium cannot be designated as a human teratogen (ACGIH (7th, 2001)). Moreover, regarding the association between lithium therapy and teratogenicity in humans, it is reported that the risk of teratogenicity at current doses of lithium treatment is very low (KemI-Riskline NR 2002:16). However, lithium therapy is contraindicated in women of childbearing potential (ACGIH (7th, 2001)). From the above, there is no clear evidence of teratogenicity in humans. However, lithium can pass through the human placenta, and lithium therapy is contraindicated in women of childbearing potential, therefore, it was classified in Category 2. In addition, it was described that lithium is excreted in milk at a rate close to serum (IPCS, PIM 309F (2000)), and that as a precautionary statement, breastfeeding should be discontinued in cases of being compelled to dose nursing women (Ethical Pharmaceuticals (2010)). Therefore, it was classified as "Additional category: Effects on or via lactation."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Lithium hydride (CAS RN 7580-67-8) is irritating and corrosive to the respiratory tract (ACGIH (7th, 2001)). There is a description that effects on the central nervous system (anorexia, nausea, tremors, muscle twitches, apathy, mental confusion, et al.) and serious burns of the respiratory tract were observed when lithium ion concentrations in the plasma rise to several mEq by exposure to lithium hydride in humans (ACGIH (7th, 2001)). As for experimental animals, there is a report that superficial sloughing of the mucosal epithelium in the trachea and persistent coughing and sneezing, leading to emphysematous changes in the lungs were observed by the inhalation exposure to 0.055 mg/L with rats within the guidance value range for Category 1 (ACGIH (7th, 2001)). From the above, since there are descriptions that it is irritating to the respiratory organs in humans and causes emphysematous changes in the lungs in experimental animals, and that it affects the central nervous system in humans, it was classified in Category 1 (central nervous system, respiratory organs).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, respiratory organs, cardiovascular system, kidney, thyroid, gastrointestinal tract)	Danger	H372	P260 P264 P270 P314 P501	Hazardous findings by exposure to lithium hydroxide are the only effects by acute exposure, and there are no reports of effects by repeated exposure. However, as for lithium compounds, lithium carbonate (CAS RN 554-13-2) and trilithium citrate (CAS RN 919-16-4), et al. which are typical substances used as drugs in the psychiatry field, there are the following findings on side effects. In an epidemiological study in which patients were given lithium salts were followed up for 13-17 years, neurological symptom (tremors, memory loss, creativity loss), effects on the thyroid (decreased function, thyroid adenoma), digestive symptom (nausea, abdominal pain, diarrhea) and polyuria were reported (IUCLID (2000)). In addition, in a study on patients were given for an average of 8 years, effects on the kidney (increased urine volume, decreased renal glomerular filtration rate (GFR), sclerotic glomeruli, renal tubular atrophy) were observed (IUCLID (2000), HSDB (Access on January 2015)). In addition, in a cooperative study in North Europe, the acute and chronic side effects from administration of lithium salts included renal toxicity, neurotoxicity, hypothyroidism, and effects on the digestive organs (Nordiac Council of Ministers (2002)) were described. Moreover, there is a description that delayed pulmonary diseases such as atelectasis, bronchopneumonia and pulmonary edema, and myocarditis with arrhythmias and conduction disturbances may occur by chronic exposure to lithium (HSDB (Access on January 2015)). Therefore, it was considered that the respiratory organs and cardiovascular system are also target organs from repeated exposure to lithium salts. From the above, although there are no reports from repeated exposure to this substance, this substance is considered to cause common the hazardous effects of lithium ions as a water-soluble lithium salt. Therefore, it was classified in Category 1 (nervous system, respiratory organs, cardiovascular system, kidney, thyroid, gastrointestinal tract).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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