NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1312-43-2
Chemical Name	Indium oxide
Substance ID	m-nite-1312-43-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	It is estimated to be not combustible, but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	It is estimated to be not combustible, but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	It is estimated to be not combustible, but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen, but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on the report of an LD 50 value of > 10,000 mg/kg (PATTY, (6th, 2012)) for rats, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described that indium and indium compounds are irritating to the skin (HSDB (Access on June 2016)). Since the information source is listed in List 3, and the original literature cannot be confirmed, this information was not adopted.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is described that indium irritates the eyes and the respiratory tract, and causes coughs and shortness of breath by inhalation (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). Therefore, this substance was classified in Category 2B.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. No in vivo data is available. As for in vitro data, it was reported a bacterial reversion mutation test was negative (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	No data is available regarding carcinogenicity in humans. As for experimental animals, in an inhalation exposure carcinogenicity test in which both rats or mice were exposed to indium tin oxide (ITO), containing 90.06% of indium oxide and 9.74% of tin oxide, at concentrations of 0.01 - 0.1 mg/m3 for 2 years (26 weeks only for rats in a high concentration group due to lung injury), in mice, no carcinogenic response occurred. As for rats, however, increases in the incidences of lung tumors such as bronchiolar-alveolar adenomas and carcinomas were observed in both males and females (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). Also, in a test in which rats or mice were exposed to indium phosphide by inhalation at concentrations of 0.03 - 0.3 mg/m3, for 2 years for the low-concentration groups and for 21 - 22 weeks for the medium- and high-concentration groups (shortened due to lung injury), bronchiolar-alveolar adenoma and carcinomas were observed in both rats and mice. In addition, increases in the incidences of pheochromocytomas of the adrenal gland, mononuclear cell leukemia, tumors of the skin and the mammary gland were observed in rats; and the incidences of liver tumors were significantly increased in mice (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013)), NTP TR499 (2001), Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). 　As the classifications by other organizations, IARC classified indium phosphide in Group 2A (IARC 86 (2006)), and the Japan Society For Occupational Health classified hardly soluble inorganic indium compounds in Group 2A (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2015)). Therefore, this substance was classified in Category 1B for this hazard class. 　Besides, because the classifications by other organizations were published after the previous classification, the classification result changed this time.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although in the Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), indium is described as irritant to the respiratory tract, it was quoted from ICSC, and the original literature could not be confirmed. Also it is not clear whether this is a description concerning only metallic indium or a description concerning indium compounds in general.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	As for humans, in Japan, there are case reports of interstitial pneumonitis and fibrosis and investigation reports showing increases in KL-6, SP-D and SP-A values, which are indicators of interstitial pneumonitis, in workers at the manufacturing and processing plants of indium tin compounds (ITO), recycling plants of indium and indium oxide manufacturing plants; and it has been clarified that lung diseases, mostly interstitial pneumonitis, occur due to exposure to ITO or indium oxide (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013)). 　As for experimental animals, in a 13-week inhalation exposure test using rats, effects in the lungs (infiltration of alveolar macrophages, alveolar proteinosis, hyperplasia of alveolar epithelium, etc.) were observed at 1 mg/m3 (converted guidance value: 0.00072 mg/L), which is equivalent to Category 1. However, for the oral route, in a 3-month administration toxicity study using rats dosed by feeding, no toxic effects were observed even at a dose equivalent to 4,000 mg/kg/day (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). 　Besides, in the previous classification, in addition to respiratory organs, the skeleton and digestive system were determined as target organs, based on the information that the TLV-TWA for indium and its compounds was set based on the skeletal and gastrointestinal effects, and particularly pulmonary toxicity by inhalation into the lungs in ACGIH (7th, 2001). However, this was based on a "Preliminary Investigation" on exposure to indium compounds by the EPA. As it was a preliminary investigation and is also considered to have low reliability due to no information other than the symptom names based on complaints, etc., it was not adopted as the evidence for the classification. 　Therefore, this substance was classified in Category 1 (respiratory organs).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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