Item | Information |
---|---|
CAS RN | 1317-34-6 |
Chemical Name | Dimanganese trioxide |
Substance ID | m-nite-1317-34-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains metals (Mn), but it is estimated that it does not react vigorously with water from the observation result of being insoluble in water (GESTIS (Access on November 2017)). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen, but the classification is not possible due to no data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Although it is not the information on this substance, the manganese salt is reported to be negative in the LLNA test (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), but details are unknown. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Although there is no data on this substance itself, EPA classified manganese in Category D (not classifiable as to human carcinogenicity) (IRIS (1995)). Therefore, based on this, this substance was classified as "Classification not possible." | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
There is no data on this substance itself. However, for the classification of reproductive toxicity of manganese and manganese compounds, Japan Society For Occupational Health (JSOH) judged as follows: in humans, although impotence and decreased libido were often observed in manganese poisoning patients, these findings remain at the level of case reports, and are slightly weak as epidemiological evidence, and in addition, the data on decreased fertility in males was also limited (OEL Documentations (2014)). On the other hand, it is reported that fetal toxicity occurred in experimental animals. From the above findings, manganese and manganese compounds were classified as reproductive toxicants Group 2 by the Japan Society For Occupational Health (JSOH) (OEL Documentations (2014)). Therefore, this substance was classified in Category 1B based on the classification results by the Japan Society For Occupational Health. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
There is no information on single exposures of this substance in humans and experimental animals. There is the information that the substance is an inorganic manganese compound and is insoluble in water (GESTIS (Access on November 2017)). In the case of manganese dioxide (CAS RN 1313-13-9), another insoluble manganese compound, it is reported that a pulmonary inflammatory reaction occurs due to a single inhalation exposure of the dust in humans and its symptoms are cough, bronchitis, pneumonia, decreased pulmonary function (CICAD 12 (1999)). Based on this information, manganese dioxide was classified in Category 1 (respiratory) in the GHS classification in FY2014. In addition, manganese carbonate (CAS RN 598-62-9), an insoluble manganese compound, for which there is no information on single exposure, but based on the information on manganese dioxide, it was classified in Category 1 (Respiratory organs) in GHS classification in FY2016. It is considered that in the case of inhalation exposure, this substance may affect the respiratory organs like other insoluble manganese compounds. Therefore, it was classified in Category 1 (respiratory organs). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Although it is not the information on this substance, when humans are exposed to excess amounts of manganese by the oral or inhalation route, memory disorders, psychiatric symptoms, etc. are observed as acute effects, and as chronic effects, symptoms of manganese addiction similar to those of Parkinson's disease are seen, such as gait disturbance and speech disorders. Serious effects were observed especially in inhalation exposure (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for the oral route, in cases of drinking well water containing high concentrations of manganese, and in epidemiological studies on residents living in regions with high manganese concentrations, symptoms similar to manganese addiction such as mask-like faces, muscle rigidity, tremors and psychiatric disorders were reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). The influence on the neurobehavioral function by exposure to the dust of manganese dioxide, trimanganese tetraoxide, and manganese salts (sulfate, carbonate, nitrate) in plants manufacturing manganese oxides and manganese salts was reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). It is reported that neurotoxicity from manganese addiction occurred by occupational exposure to manganese dioxide, and that in addition to decreases in visual simple reaction time and in eye-hand coordination, rigidity of the hands was observed (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). Furthermore, many case reports revealed that manganese compounds, mainly manganese dioxide, produce respiratory disorders (cough, bronchitis, pneumonia, etc.) (ATSDR (2012)). No information is available for experimental animals. Therefore, this substance was classified in Category 1 (nervous system, respiratory organs). |
FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|