Item | Information |
---|---|
CAS RN | 1317-38-0 |
Chemical Name | Copper(II) oxide |
Substance ID | m-nite-1317-38-0_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on August 2016)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on August 2016)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on August 2016)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water due to the observation result of being insoluble in water (Merck (15th, 2013)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an inorganic compound containing oxygen, but the classification is not possible due to no data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the report of an LD50 value (OECD TG 423) of >2,000 mg/kg (SIAP (2014)) for rats, this substance was classified as "Not classified." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the report on an LD50 value (OECD TG 402) of >2,000 mg/kg (SIAP (2014)) for rats, this substance was classified as "Not classified." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, an LC50 value of >2.08 mg/L (EPA RED (2006)) for rats has been reported, but classification is not possible due to unknown exposure time. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Mild irritation (PI Index 1.49) was observed in a rabbit skin irritation test (EPA RED (2009)), so this substance was considered to be "Not classified" (Category 3 in UN GHS classification). Also, it is reported that in a skin irritation test (OECD TG 404) using rabbits, it is not irritating (SIAP (2014)). Therefore, this substance was classified as "Not classified" (Category 3 in UN GHS classification). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Additionally, in an eye irritation test using rabbits, although the details are unknown, there is a description that irritation was observed but resolved after 7 days (EPA RED (2009)). On the other hand, irritation was not observed in an eye irritation test (OECD TG 405) using rabbits (SIAP (2014)). Since conflicting data exists, this substance was classified as "Classification not possible." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Category 1A |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
According to the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016), copper and copper compounds are designated as Group 2 of occupational skin sensitizer, so this substance was classified in Category 1A. Additionally, a negative (no reaction at 48 hours after challenge) was reported in a skin sensitization test (OECD TG 406, maximization test) using guinea pigs (SIAP (2014)), and a negative was also reported in a skin sensitization test using guinea pigs (EPA RED (2009)), but it was not adopted as the evidence of the classification because the details are unknown. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (systemic), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
It is described that, in humans, inhalation of fine dust particles of this substance can result in sneezing, coughing, digestive disorders and fever (DFGOT vol. 22 (2004)). It is also reported that metal fume fever accompanied with high fever, shivering, headaches, dryness in the mouth and throat, dysgeusia, nausea, shortness of breath, and myalgia occurred by acute inhalation exposure to copper fumes during the process of welding copper (DFGOT Vol. 22 (2004), Environmental Risk Assessment for Chemical Substances Vol.13 (Ministry of the Environment, 2015), HSDB (Access on September 2016)). This substance may also be contained in copper fumes. From the above, this substance was classified in Category 1 (systemic toxicity), and in Category 3 (respiratory tract irritation). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Additionally, in humans, according to health examination records (between 1970 and 1973) of workers (75 to 100 people) who engaged in the grinding and sieving processes of high purity copper at a copper smelting plant, 39 to 70% of the workers showed hepatomegaly, 10 to 15 % showed digestive disorders and 16% showed sexual impotence. It was reported that the copper concentration in the workplace ranged from 464 mg/m3 in 1971 to 111 mg/m3 in 1973. Using normal levels (0.8 - 1.2 mg/L) based on serum levels of copper (0.76-1.17 mg/L) in unexposed workers, it is reported that a rate of workers whose levels exceeded the normal ones increased from 40% to 92% in 1970-1973 (Environmental Risk Assessment for Chemical Substances Vol.13 (Ministry of the Environment, 2015), DFGOT Vol. 22 (2004), EHC 200 (1998)). However, it is described that since there is neither control group nor the description on methods for measuring exposure concentration, severely limit the usefulness (EHC 200 (1998)). Also as for experimental animals, although details are unknown, it was reported in a Russian report that, in a study using male rats exposed to copper oxide aerosol by inhalation for 90 to 100 days, decreases in hemoglobin concentration and serum protein concentration, testicular relative weight, sperm motility rate, and sperm viability were observed in the groups of 0.01 mg/m3 or above, and significant increases in red blood cell count were observed in the groups of 0.1 mg/m3 or above (Environmental Risk Assessment for Chemical Substances Vol.13 (Ministry of the Environment, 2015)). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From LC50 (unknown time) = 3.1 ppb for algae (Pseudokirchneriella subcapitata) (U.S. EPA: RED, 2009), it was classified in Category 1. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Although environmental dynamics of the inorganic compound is unknown, due to NOEC (unknown time) = 0.2 ppb for algae (Pseudokirchneriella subcapitata) (US EPA: RED, 2009), it was classified in Category 1. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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